Available Positions

POSTDOCTORAL POSITIONS

Two Postdoctoral positions are available immediately to study the most common childhood neurological disorder, Batten disease. The specific areas of research are: 1. Elucidating the contribution of a novel autoimmune response to GAD65 that exists in both individuals with Batten disease, and a mouse model for the disease (Chattopadhyay et al, 2002 [Hum. Mol. Genet. 11, 1421-1431]). 2. Determining the biochemical and pathological cascades that occur in the developing CNS of a mouse model for Batten disease. We are looking for highly motivated individuals with experience in immunology and molecular biology and molecular neuroscience for each position, respectively, to contribute to the research and understanding of this devastating disease. For more information please contact: David A Pearce, Ph.D.; Center for Aging and Developmental Biology/Department of Biochemistry and Biophysics; University of Rochester School of Medicine and Dentistry; 601 Elmwood Ave. Box 645; Rochester, NY 14642 Tel: 585 273 1514 FAX: 585 506-1972 E-Mail: David_Pearce@urmc.rochester.edu

POSTDOCTORAL POSITION

A Postdoctoral position is available immediately to study the function of Btn1p in yeast. Btn1p is the yeast homologue to the human Cln3p which when defective is responsible for the most common childhood neurological disorder, Batten disease. We are studying Btn1p with the awesome power of yeast genetics, and have demonstrated that deletion of BTN1 (btn1-D) is complemented by human CLN3 (Pearce et al., 1999 [Nat. Genet., 22, 55-58]). We are looking for a highly motivated individual with experience in yeast molecular biology to contribute to the research and understanding of this devastating disease. For more information please contact: David A Pearce, Ph.D.; Center for Aging and Developmental Biology/Department of Biochemistry and Biophysics; University of Rochester School of Medicine and Dentistry; 601 Elmwood Avenue, Box 645; Rochester, NY 14642 Tel: 585 273 1514 FAX: 585 506-1972 E-Mail: David_Pearce@urmc.rochester.edu

RESEARCH ASSISTANT PROFESSOR POSITION

Pharmacogenomic Approaches in Alzheimer's Disease

Research Assistant Professor position is available September 1, 2002, to identify and characterize, utilizing proteomic and genomic approaches, molecular targets contributing to pathogenesis in Alzheimer's disease. Applicants must have a Ph.D., 2 years post-doctoral training and experience in molecular neurobiology or cell biology. Send a curriculum vitae and arrange to have three letters of recommendation forwarded to: Howard J. Federoff, M.D., Ph.D.; University of Rochester School of Medicine and Dentistry; Center for Aging and Developmental Biology; 601 Elmwood Ave., Box 645; Rochester, NY 14642

POSTDOCTORAL POSITION

Somatic Mosaic Murine Models to Elucidate the Function of Nerve Growth Factor in the Adult CNS

Post-doctoral position available September 1, 2002 to investigate the function of neurotrophins in the adult CNS. Specifically, somatic mosaic transgenic mice are being used to understand the role of NGF in spatial learning and memory. Applicants must have a Ph.D. and experience in molecular neurobiology, proteomics and histologic methods. Send a curriculum vitae and arrange to have three letters of recommendation forwarded to: Howard J. Federoff, M.D., Ph.D.; University of Rochester School of Medicine and Dentistry; Center for Aging and Developmental Biology; 601 Elmwood Ave., Box 645; Rochester, NY 14642

POSTDOCTORAL POSITION

Application of HSV Amplicon Vectors as Vaccines for Neurodegenerative Diseases

Postdoctoral position available September 1, 2002 to construct and evaluate HSV-1 amplicon vectors as vaccines in animal models of neurodegenerative disorders. Applicants must have a Ph.D. and experience in molecular neurobiology, cell biology or virology. Send a curriculum vitae and arrange to have three letters of recommendation forwarded to: Howard J. Federoff, M.D., Ph.D.; ; University of Rochester School of Medicine and Dentistry; Center for Aging and Developmental Biology; 601 Elmwood Ave., Box 645; Rochester, NY 14642

POSTDOCTORAL POSITION

NGF and Septohippocampal Plasticity

A postdoctoral position is available for an individual interested in joining an NIH-funded interdisciplinary research program focused on investigating the cellular and molecular mechanisms underlying neurotrophin-induced functional plasticity along the septohippocampal pathway. Experimental approaches combine patch clamp electrophysiology in brain slices, quantitative analysis of gene and protein expression in single cells and targeted gene transfer to induce somatic mosaic intrahippocampal activation of NGF. The successful candidate should have a solid background in either electrophysiology or molecular biology; practical knowledge in both is a plus. Send letter, curriculum vitae and a list of references to: Dr. Hermes H. Yeh, University of Rochester School of Medicine and Dentistry; 601 Elmwood Ave., Box 645; Rochester, NY 14642. E-mail: hermes_yeh@urmc.rochester.edu.

POSTDOCTORAL POSITION

Neurogenesis in the Adult Mammalian Brain

A postdoctoral position is immediately available to investigate the behavior and regulation of endogenous neural stem cells in the adult mammalian brain, and to asses their therapeutic potential to replace neurons lost to neurodegenerative disease or injury. Experimental approaches include: immunocytochemistry and confocal microscopic imaging, cell counting and stereological analysis, stereotaxic brain surgery in nonhuman primates and rodents, and application of viral vectors encoding neurotrophic molecules. Preference will be given to candidates with experience in molecular biology, immunocytochemistry, gene therapy and/or neuroanatomical techniques, although applicants with strong background in related disciplines are also encouraged to apply. The University of Rochester and Center for Aging and Developmental Biology offer a stimulating scientific environment, and excellent opportunities for interactions and training in developmental and regenerative neuroscience. Send or email CV, statement of research interests, and names of three references to: Dr. David Kornack: University of Rochester School of Medicine and Dentistry; Center for Aging and Developmental Biology; 601 Elmwood Avenue, Box 645; Rochester, NY 14642 E-mail: david_kornack@urmc.rochester.edu