William J. Bowers, Ph.D.
Assistant Professor of Neurology
Ph.D. 1995, University of Rochester

Research: Dissecting the dynamic interplay between inflammation and neurodegeneration using novel transgenic modeling and viral vector-based gene transfer

The Bowers laboratory is interested in assessing the contribution of inflammation in the pathophysiology of Alzheimer’s disease (AD).  Novel transgenic mice and gene transfer-based methodologies are being employed to experimentally control the expression and/or activity of potent inflammatory cytokines/chemokines due to their purported role(s) in brain inflammation and neurodegeneration. The laboratory is also developing novel vaccines and therapeutics based upon the Herpes simplex virus (HSV) amplicon vector platform for future implementation in a clinical setting.

Bowers Web-Site