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Pediatrics Department
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Center for Pediatric Biomedical Research
James Palis, M.D., Interim Scientific Director
Research in the Center has as its ultimate aim the improvement in children's health. There are two major research efforts ongoing in the Center. The first entails the study of stem and progenitor cell biology. Understanding the developmental origins and regulation of stem cells will provide important insights into tissue maintenance and organ repair for the eventual treatment of multiple chronic disease states that afflict children. These studies will also elucidate pathways of oncogenesis that will be important for the development of improved therapies for the most common forms of childhood cancers. These studies take advantage of a state-of-the-art cell sorting facility located in the Center. The second major research effort entails the development of new technologies to investigate protein structure and function on a genomic scale. Current studies focus on membrane and soluble proteins of pathogenic protozoa and the generation of antibodies to proteins using a phage display library that ultimately will lead to rational structure-aided drug design. The Center occupies 20,000 square feet on the first floor of the newly built Medical Research Building. The open research environment found within the Center fosters multidisciplinary interactions and engenders an ideal training environment for graduate students and post-doctoral fellows. |
