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Pediatrics Department
Aab Institute
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Paul Kingsley
Research Assistant Professor
Department of Pediatrics and the
Center for Pediatric Biomedical Research
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Education:
B.A., Biology; Reed College, 1982
Ph.D., Developmental Biology; University of Rochester, 1994
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Contact Information:
E-mail: Paul Kingsley
Tel: 585-275-5883 (office); 585-275-5852 (lab)
Fax: 585-276-0232
Location:
MRBX Building
Rm. 1.11104 (office); Rm. 1.11301 (lab)
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Summary of Research Interests:
Our research focuses on embryonic hematopoiesis. Formation of blood is a critical early event for mammalian embryos, initially occurring in the extraembryonic yolk sac of the gastrulating embryo, then migrating to the fetal liver, before homing to the bone marrow at the end of gestation. Our recent work indicates the first so called "primitive" wave of blood cell formation is more robust than previously thought, being multilineage in nature. Current projects in the lab include investigations of primitive red cell maturation, circulation and enucleation, as well as in vivo lineage tracing of yolk sac mesoderm-derived hematopoietic precursors. While our model systems are often derived from primary murine tissues, we also utilize embryonic stem cells from both mouse and human to form hematopoietic embryoid bodies.
Recent Publications:
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Kingsley PD, McGrath KE, Maltby KM, Koniski AD, Ramchandran R, Palis J. Subtractive hybridization reveals tissue specific expression for ahnak during embryonic development. Dev Growth Differ 43:133-143, 2001
- Kingsley PD , Malik J, Fantauzzo KA, Palis J. Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood 104:19-25, 2004
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