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Pediatrics Department
Aab Institute
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Kathleen McGrath
Research Assistant Professor
Department of Pediatrics and the
Center for Pediatric Biomedical Research
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Education:
B.A., Biology; Reed College, 1983 Ph.D., Biology; University of Rochester, 1993
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Contact Information:
E-mail: Kathleen McGrath
Tel: 585-275-5883 (office); 585-275-5852 (lab)
Fax: 585-276-0232
Location:
MRBX Building
Rm. 1.11104 (office); Rm. 1.11301 (lab)
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Summary of Research Interests:
My research interest is based on a fundamental curiosity about how cells decide which fate to adopt as embryos develop. Simplistically, this involves a dynamic interplay between the potential each cell has and the signals that it receives that narrow that potential into specific fates. As part of Jim Palis’ research group, I apply that paradigm to the development of the blood system in the mouse embryo. Recently, I have focused on the initial appearance of the linked fates of blood and vascular systems in the embryo and roles of signaling systems active at the time and place of these initial fate choices (e.g. Notch, BMP and Wnt signaling systems). I have also begun to examine the genetic control of later steps in the maturation of specific lineages within the blood system in the embryo versus the adult utilizing cell sorting technologies.
Recent Publications:
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McGrath K.E., Koniski, A.D., Malik, J, and J. Palis. Circulation is established in a step-wise pattern in the mammalian embryo. Blood 101:1669-1675, 2003
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Ji RP, Phoon CKL, Aristizabal O, McGrath KE, Palis J, Turnbull DL. Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper. Circ Res 92:133-135, 2003
- McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis, J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol 213:441-456, 1999
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