George H. Whipple Laboratory for Cancer Research (Director Dr. Chawnshang Chang)

Dr. Chang's Publications at University of Rochester Period (1997-2007)

Choose Publication Period:

1980 ~1990

Publications at University of Chicago Period

1990 ~1997

Publications at University of Wisconsin-Madison Period

1997 ~ 2008

Publications at University of Rochester Period

Lin M-F, Meng T-C, Roa PS, Chang C, Schonthal AH, and Lin F-F (1998) "Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines." J. Biol. Chem. 273, 5939-5947.
Uemura H and Chang C (1998) "Antisense TR3 orphan receptor can increase prostate cancer cell viability with Etoposide treatment." Endocrinology 139, 2329-2334.
Lin D-L Wu S-Q, and Chang C (1998) "The genomic structure and chromosomal location of the human TR2 orphan receptor: a member of steroid receptor superfamily." Endocrine 8, 123-134.
Lee Y-F, Young W-J, Burbach JPH and Chang C (1998) "Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor: a member of steroid receptor superfamily." J. Biol. Chem. 273, 13437-13443.
Yeh S, Miyamoto H, Shima H and Chang C (1998) "From estrogen to androgen receptor: a new pathway for sex hormone in prostate." Proc. Natl. Acad. Sci. 95, 5527-5532.
Miyamoto H, Yeh S, Wilding G, and Chang C (1998) "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells." Proc. Natl. Acad. Sci. 95, 7379-7384.
Huang S-B, Burbach JPH and Chang C, (1998) "TR4 orphan receptor crosstalks to chicken ovalbumin upstream protein-transcription factor and thyroid hormone receptor to induce the transcriptional activity of the human immunodeficiency virus type-1 long terminal repeat." Endocrine, 8, 169-175.
Su C, Chong K, Dillmann W, Chang C, Owen O, and Lai C (1998) "Constitutive and inducible hsps70s are involved in oxidative resistance evoked by heat shock or ethanol" J. Mol. Cell Cardiology. 30, 587-598.
Chong K-Y, Lai C-C, Lilly S, Chang C, and Su C-Y (1998) "Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection." J. Mol. Cell Cardiol. 30, 599-608.
Miyamoto H, Yeh S, Huang S-B, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C, Uemura H, Kang H, and Chang C (1998) "The Androgen Receptor Coregulator ARA70" in Molecular Basis of Sex Hormone Receptor Function (Gronemeyer H, Fugymann U and Parczyk ed) pp. 43-51, Springer, Berlin.
Young W-J, Lee Y-F, Smith SM, and Chang C (1998) "A bi-directional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNFT) signaling pathway." J. Biol. Chem. 273, 20877-20885.
Chen X, Zachar V, Chang C, Ebbesen P, and Liu X (1998) Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: transactivation of the TR3/Nur77 gene by Tax protein." J. Of Virology. 72, 6902-6906
Young W-J and Chang C (1998) "Ontogeny and autoregulation of androgen receptor mRNA expression in the nervous system." Endocrine 9, 79-88.
Chang C and Pan, H-J (1998) "Thyroid hormone direct repeat 4 response element is a positive regulatory element for the human TR2 orphan receptor, a member of the steroid receptor superfamily." Mol. Cel. Biochem. 189, 195-200.
Mu X. Young W-J, Liu Y-X, Uemura H, and Chang C (1998) "Induction of an intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRa) gene by the TR3 orphan receptor" " Endocrine 9, 27-32.
Pan H-J, Wilding G, Uno H, Inui S, Goldsmith L, Messing E, and Chang C (1998) "Evaluation of RU58841 as an antiandrogen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of Stumptailed Macaques." Endocrine 9, 39-43.
Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, and Chang C (1998) "Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells." Biomed. Biophysic. Res. Commun. 248, 361-367.
Jarrard DF, Kinoshita H, Shi Y, Sandefur C, Hoff D, Meisner LF Chang C Herman JG, Isaacs WB, and Nassif N (1998) "Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells." Cancer Research 58, 5310-5314.
Cardillo MR, Petrangeli E, Aliotta N, Salvatori L, Ravenna L, Chang C, and Castagna G (1998) "Androgen receptors in ovarian tumors: correlation with Oestrogen and progesterone receptors in an immunohistochemical and semiquantitative image analysis study." J. Exp. Clin. Cancer Res. 17.2, 231-237.
Miyamoto H, Yeh S, Lardy H, Messing E, and Chang C (1998) "Delta5-Androstenediol is a natural hormone with androgenic activity in human prostate cancer cells." Proc. Natl. Acad. Sci.19, 11083-11088.
Cardillo MR, Petrangeli E, Ravenna L, Salvatori L, Chang C, DiSilverio F (1998) "Immunohistochemical quantification and determination of Cathepsin D in prostatic neoplasia: correlation with steroid". Applied Immunohistochemistry 6(3), 133-139.
Kang H-Y, Yeh S, Fujimoto N, and Chang C (1999) "Cloning and characterization of human prostate coactivator, ARA54, a novel protein that associates with the androgen receptor." J. Biol. Chem. 274, 8570-8576.
Mu XM, Liu YX and Chang C (1998) "Mechanism of the interaction between orphan receptor TR3 and cis-acting element in CNTFRa gene." Chinese J. Biochemistry and Molecular Biology 14, 484-492.
Yeh S, Chang H, Miyamoto H, Takatera H, Rahman M, Kang H, Thin T, Lin D, and Chang C (1999) "Differential induction of androgen receptor transcriptional activity by selective androgen receptor coactivators." Keio J. of Medicine 48, 87-92.
Wang C, Young W-J, and Chang C (1999) "Androgen effects on the solubility and conformational change of androgen receptor in baculovirus expression system." Mol. Cel. Biochem. 195, 19-23.
Inui, S, Lee Y-F, Haake AR, Goldsmith LA, and Chang C (1999) "Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes" in: Journal of Investigative Dermatology 112, 426-431.
Heinlein CA, Ting H-J, Yeh S and Chang C (1999) "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma." J. Biol. Chem 274, 16147-16152.
Yeh S, Lin H-K, Kang H-Y, Thin TH, Lin M-F, and Chang C (1999) "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells." Proc. Natl. Acad. Sci. 96, 5458-5463.
Lee H-J, Lee Y-F, and Chang C (1999) "Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor." Mol. Cel. Biochem. 194, 199-207.
Lee Y-F. Young W-J, Lin W-J, Shyr C-R, and Chang C (1999) "Differential regulation of direct repeat 3 Vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor." J. Biol. Chem. 274, 16198-16205.
Hsiao P and Chang C (1999) "Isolation and characterization of ARA160 as an androgen receptor N-terminal associated coactivator in human prostate cells." JBC 274, 22373-22379.
Hsiao P, Lin D, Nakao K, and Chang C (1999) "The linkage of the Kennedy�s neuron disease to ARA24, the first identified androgen receptor poly-glutamine region-associated coactivator." J. Biol. Chem. 274, 20229-20234.
Yang C, Yeh S, Leskov K, Odegaard E, Hsu H, Chang C Kinsella T, Cheb D, and Boothman D (1999) "Isolation of Ku70-binding proteins (KUBs)." Nucleic Acid Res.27, 2165-2174.
Fujimoto N, Yeh S, Kang H-Y, Inui S, Chang H-C, Mizokami A, and Chang C (1999) "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate." J. Biol. Chem 274, 8316-8321.
Lee Y, Shyr C, Thin T, and Chang C (1999) "Convergence of two repressors through heterodimer formation of androgen receptor and TR4 orphan nuclear receptor: a new signaling pathway in the steroid receptor superfamily." Proc. Natl. Acad. Sci. 96, 14724-14729.
Shih C, Young W, Wang C, Jin L, Ji X, Guan Q, Wang M, and Chang C (1999) "Monoclonal anti-androgen receptor antibodies: production, characterization and potential diagnostic applications. " Mol. Cel. Biochem. 201, 131-140.
Kameoka Sei, Leavitt P, Chang C, and Kuo SM (1999) "Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids." Cancer Letters 146, 161-167.
Yeh S, Kang H, Miyamoto H, Nishimura K, Chang H, Fujimoto N, Ting H, Mizokami A, Huang K, and Chang C (1999) "Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate DU145 cells." Endocrine 11, 195-202.
Chang HC, Miyamoto H, Yeh S, Lardy H, and Chang C (1999) "Suppression of Delta5-Androstenediol-induced AR transactivation by selective steroids in human prostate cancer cells " Proc. Natl. Acad. Sci 96, 11173-11177.
Pan H, Uno H, Obana N, and Chang C (1999) "The roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells." Endocrine 11, 321-327.
Liu X, Chen X, Zachar V, Chang C, and Ebbesen P (1999) "Transcriptional activation of human TR3/nur77 gene expression by human T-lymphotropic Virus type I Tax protein through two AP-1-like elements" J. of General Virology 80, 3073-3081.
Miyamoto H and Chang C (2000) "Antiandrogens fail to block completely the androstenedione-induced mutated androgen receptor transactivation in human prostate cancer cells." International J. Urology. 7, 32-34.
Inui S, Itami S, Pan H, and Chang C (2000) "Lack of androgen receptor transcriptional activity in human keratinocytes." J. Dermatological Science 23, 87-92.
Nishimura K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh S, and Chang C (2000) "Yeast two-hybrid screening of associated proteins and characterization of mutant androgen receptors." 329-343 in Yeast Hybrid Technologies. (Zhu L and Hannon G ed). Eaton Publishing.
Lin D and Chang C (2000) "Identification and characterization of an essential cis-acting element (TR2-PACE) in the 5� promoter of human TR2 orphan nuclear receptor gene" Endocrine 12, 89-97.
Hsiao P, Thin T, Lin D and Chang C (2000) "Differential regulation of testosterone vs 5a-dihydrotestosterone by selective androgen response elements" " Mol. Cel. Biochem. 206, 169-175.
Wang C, Young W and Chang C (2000) "Isolation and characterization of androgen receptor mutants with divergent transcriptional activity in response to hydroxyflutamide." Endocrine 12, 69-76.
Lee K, Duo J, Hsiao P, and Chang C (2000) " From androgen receptor to general transcription factor TFIIH: Identification of cdk Activating Kinase as an AR N-terminal associated coactivator." J. Biol. Chem. 275, 9308-9313.
Hsing A, Gao Y, Wu G, Chen Y, Deng j, Sesterhenn I, Mostofi F and Chang C (2000) "Polymorphic CAG/CAA repeat length in the androgen receptor gene and prostate cancer risk: a population-based case-control study in china" Cancer Research 60, 5111-5116.
Yeh S, Hu Y, Rahman M, Lin H, Ting H, Kang H, and Chang C (2000) "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells." PNAS 97, 11256-11261.
Yeh S, Sampson E, Lee OK, Kim E, Hsu C, Chen Y, Chang T, Altuwaijri S, Huang K, and Chang C (2000) "Functional analysis of N-terminal and Ligand-binding domain of androgen receptor coactivators in prostate cancer." J. Formosan Medical Association 99, 885-894.
Schaick H, Rosmalen J, Silva S, Chang C and Burbach P (2000) "Expression of the orphan receptor TR4 during brain development of the rat" Mol. Brain Res. 77, 104-110.
Mu X, Liu Y, Collins L, Kim E and Chang C (2000) "The p53/Rb-mediated repression of testicular orphan receptor-2 in the rhesus monkey with crytorchidism." J. Biol. Chem. 275, 23877-23883.
Kinoshita H, Shi Y, Sandefur C, Meisner L, Chang C, Choon A, Reznikoff C, Bova S, Friedel A, and Jarrard D (2000) "Methylation of the androgen receptor minimal promoter silences transcription in human prostate cancer." Cancer Research 60, 3623-3630.
Kang HY, Lin HK, Hu YC, Yeh S, Huang KE and Chang C (2001) "From TGF-b signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells" Proc. Natl. Acad. Sci. 98, 3018-3023.
Lee DK, Duan HO and Chang C (2001) "Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation" J. Biol. Chem 276, 9978-9984.
Lin H, Yeh S, Kang H. and Chang C (2001) "Akt suppresses androgen-induced apoptosis by phosphorylatiing and inhibiting androgen receptor." Proc. Natl. Acad. Sci 98, 7200-7205.
Heinlein CA and Chang C (2001) "The role of chaperones in the nuclear translocation and transactivation of steroid receptors" Endocrine 14, 143-149.
Mantalaris A, Panoskaltsis N, Sakai Y, Bourne P, Messing E, Chang C, and Wu D (2001) "Localization of androgen receptor expression in human bone marrow." J. Pathology 193, 361-366.
Si M, AI-Sharafi B, Lai C, Khardori R, Chang C, and Su C. (2001) "Gender difference in cytoprotection induced by estrogen on female and male bovine aortic endothelial cells." Endocrine 15, 255-262.
Sampson E, Yeh S, Chang H, Tsai M, Wang X, Ting H-J, and Chang C (2001) "Identification and characterization of androgen receptor associated coregulators in prostate cancer cells." J. Biological Regulation & Homeostatic Agents 15, 123-129.
Collins L, Lin D, Mu X, and Chang C (2001) "Feedback regulation between orphan nuclear receptor TR2 and human papilloma virus type 16." J. Biol. Chem. 276, 27316-27321.
Lee HJ, Lee YF, and Chang C (2001) "TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif." Biochem. Biophys. Res. Commun. 285, 1361-1368.
Wang X, Yeh S, Wu G, Hsu C, Wang L, and Chang C (2001) "Cloning and characterization of androgen receptor coregulator, ARA267-a in prostate cancer cells." J. Biol. Chem. 276, 40417-40423.
Kuo SM, Huang CT, Blum PB, and Chang C (2001) "Quercetin cumulatively enhances copper induction of metallothionein in intestinal cells." Bio.Trace Element Res. 84, 1-10.
Inui S, Nakajima T, Fukuzato Y, Fujimoto N, Chang C, Yoshikawa K, Itami S (2001) "Potential anti-androgenic activity of roxithromycin in skin. "J Dermatol Sci. 27 (2):147-51.
Heinlein C and Chang C (2002)�Structural and Functional Analysis of the Androgen Receptor� pp17-56 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed).
Kluwer, USA. Li M, Richter F, Chang C, Irwin RJ and Huang H.(2002)"Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor" BMC Cancer 2:16-23.
Miyamoto H, Rahman M, Takatera H, Kang H, Yeh S, Chang H, Nishimura K, Fujimoto N, and Chang C (2002) "A dominant-negative mutant of androgen receptor coregulator, ARA54 inhibits androgen receptor-mediated prostate cancer growth." J. Biol. Chem. 277, 4609-4617.
Heinlein C and Chang C (2002)�Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity� pp 57-90 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
Schinner S, Dellas C, Schroder M, Heinlein C, Chang C, Fischer J and Knepel W (2002) "Repression of glucagon gene transcription by PPARg through inhibition of Pax6 transcriptional activity." J. Biol. Chem. 277, 1914-1948.
Shyr C, Hu YC, Kim ES, and Chang C (2002) "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in breast cancer MCF-7 cells." J. Biol. Chem. 277, 14622-14628.
Heinlein C, Sampson E and Chang C (2002) �Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors� pp 91-138 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed).Kluwer, USA.
Ting H, Yeh S, Nishimura K, and Chang C (2002) "Supervillin associated with androgen receptor and modulates its transcriptional activity" Proc Natl. Acad. Sci .99, 661-666.
Hsing A, Chokkalingam A, Gao Y, Wu G, Wang X, Deng j, Cheng J, Sesterhenn I, Mostofi F, Chiang T, Chen Y, Stanczyk F, and Chang C (2002) "Polymorphic CAG/CAA repeat length in the A1B1/SRC-3 gene and prostate cancer risk: a population-based case-control study." Cancer Epidemiology, Biomakers and Prevention 11, 337-341.
Shyr C, Collins L, Mu XM, Platt KA and Chang C (2002) "Spermatogenesis and testes development are normal in mice lacking the testicular orphan nuclear receptor-2 (TR2)." MCB. 22, 4661-4666.
Heinlein C and Chang C (2002)�Nongenomic Androgen Action� 139-154 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
Wang X, Yang Y, Guo X, Sampson E, Hsu CL, Tsai MY, Wu G, Guo Y and Chang C (2002) "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator J. Biol. Chem. 277, 15426-15431.
Heinlein CA, and Chang C (2002) "Androgen receptor coregulator: an overview" Endocrine Review. 23, 175-200.
Lin HK, Wang L, Hu YC, Altuwaijri S and Chang C (2002)"Phosphorylation-dependent ubiquitination and degradation of AR by Akt requires Mdm2 E3 ligase" EMBO 21, 1-12.
Fu M, Wang C, Wang J, Zhang X, sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua S, Jaffray E, Hay RT, palvino JJ, Janne OA and Pestell R (2002) "Androgen receptor acetylation governs transactivation and MEKK1-induced apoptosis without affecting in vitro sumoylation and transrepression function." MCB 15, 3373-3388.
Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collin L, Basavappa R, and Chang C (2002) "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17b-estrodiol-induced androgen receptor transactivation" J. Biol. Chem. 277, 36499-36508.
Hsing A, Culig Z, Wang X, Uemura H and Chang C (2002) �The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications� pp 245-264 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
Hu YC, Shyr CR, Che S, Mu XM, Kim E and Chang C (2002) "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor" J. Biol. Chem. 277, 33571-33579.
Collins L, Mu X and Chang C (2002) �Androgens in Spermatogenesis and Contraception� pp 299-324 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
Lee Y, Lee H and Chang C (2002) "Recent advances in the TR2 and TR4 orphan receptors of nuclear receptor superfamily. JSBMB 1728, 1-17.
Sampson E, Yeh S. Miyamoto H, Lee DK, Tsi, MY, Wang X, Hsu CL, and Chang C (2002) "Interaction of cell cycle regulatory proteins with the androgen receptor." pp 223-238 in Steroid hormones and cell cycle regulation. (Burnstein KL ed). Kluwer, USA.
Lin HK, Hu YC, Altuwaijri S and Chang C (2002) "Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells." J. Biol. Chem. 277, 36570-36576.
Lee Y, Lin W, Huang J, Messing E, C Kuo, Wilding G, and Chang C (2001) "Activation of MAP kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor negative prostate cancer cells." Cancer Research 62, 6039-6044.
Itami S. Inui S, Uno H, Pan H, Chang E, Takayasu S, Ye F, Imamura K, Seki T, Ideta R, Aoki H, Adachi K, Price V, Kurata S, Collins L, Heinlein C and Chang C (2002) "Androgens in Dermatology: Hair Loss, Acne, and Other Diseases." pp 411-476 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
Heinlein CA, and Chang C (2002) "The roles of AR and androgen binding proteins in nongenomic androgen actions." Mol. Endo. 16, 2181-2187.
Yeh S, Tsai MY, Xu Q, Mu X, lardy H, Huang KE, Lin H, Yeh SD, Altuwaijrl S, Zhou X, Xing L, Boyce B, Hung MC, Zhang S, Gan L and Chang C (2002) "Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues." Proc Natl. Acad. Sci. 99,13498-13503.
Ohtsu H, Ishida J, Nagai M, Wang H, Itokawa H, Su C, Shih C, Chiang T, Chang E, Lee Y, Tsai M, Chang C and Lee K (2002) "Antitumor agents 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents." J. of Medicinal Chemistry 45, 5037-5042.
Shih C, Chang E, Zhang Y, Lai C, Su C, Chen Y, Chang H, Chiang T and Chang C (2002) "The use of a flow cytometry analysis in the study of different expression of androgen receptor in human prostate cancer LNCaP and PC-3 cells." New Taipei Journal of Medicine 4, 151-158.
Kang H, Huang KE, Chang S, Ma WL, Lin WJ and Chang C (2002) "Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4." J. Biol. Chem. 277, 43749-43756.
Lin J, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH and Chang C (2003) "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." J. Biol. Chem. 278, 9353-9360.
Yang Y, Wang X, Dong T, Kim E, Lin WJ and Chang C (2003) "Identification of a novel TR4 orphan receptor associated protein (TRA16) as repressor for the selective suppression of TR4-mediated transactivation." J. Biol. Chem. 278, 7709-7717.
Lee DK and Chang C (2003) "Molecular communication between androgen receptor and general transcription machinery." JSBMB 84, 41-49.
Thin TH, Kim E, Basavappa R, and Chang C (2003) "Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to the 17-beta estradiol treatment." J. Biol. Chem. 278, 7699-7708.
Rahman MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S and Chang C (2003) "Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 mutant in prostate cancer cells."J. Biol. Chem. 278, 19619-19626
Rahman MM, Miyamoto H, Kan PY, Lardy H and Chang C (2003) "Inactivation of androgen receptor (AR) coregulator ARA55 leads to an inhibition of AR transactivation and a reduction of the agonist activity of antiandrogens in prostate cancer cells." Proc Natl. Acad. Sci. 100, 5124-5129
Lee DK, Li M and Chang C (2003) "The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor." BBRC 302, 162-169.
Miyamoto H, Marwah P, Lardy H and Chang C (2003) "3b-Acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity." Proc Natl. Acad. Sci. 100, 4440-4444.
Yang L, Lin HK, Altuwaijri S, Xie S and Chang C (2003) "APPL suppresses androgen receptor transactivation via potentiating Akt activity." J. Biol. Chem. 278,16820-16827.
Hsu CL, Yeh S, Chen YL, Ting HJ, Hu YC, Hank L, Wang X and Chang C (2003) "The use of phase display technique for the isolation of androgen receptor interacting peptides with F/WXXLF/W and FXXLY new signature motifs." J. Biol. Chem. 278, 23691-23698.
Mu X, and Chang C. (2003) "TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells". J. Biol. Chem. 278, 42840-42845.
Kim E, Xie S, Lee YF, Collins L, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH, and Chang C (2003) "ApoE-TR4 orphan nuclear receptor induces the expression of liver apolipoprotein E/C-I/C-II gene cluster via hepatic control region." J. Biol. Chem. 278, 46919-46926.
Lee HJ, Sampson ER, Hsu CL, Chen YT and Chang C (2003) "Androgen receptor." pp 87-101 in Molecular mechanisms of action of steroid receptors (Marija and Costas Demonacos ed). Research Signpost, India.
Chey WY, Chang CH, Pan H, Chang C, Kim BK, Park IS and Chang TM (2003) "Evidence on the presence of secretin cells in the gastric antral and oxyntic mucosa." Regulatory Peptides 111, 183-190.
Yang L, Wang L, Lin HK, Kan P, Xie S, Tsai MY, Wang PH, Chen YT and Chang C (2003) "Interleukin-6 differentially regulates androgen receptor transavtivation via PI3K-Akt, STAT3 and MAPK three distinct signal pathways in prostate cancer cells." BBRC. 305, 462-469.
Lee H, and Chang C (2003) "Recent advances in the androgen receptor action." Cellular and Molecular Life Sciences. 60, 1613-1622.
Inui, S, Lee Y, Chang E, Shyr CR and Chang C (2003) "Differential and bidirectional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor a (PPARa) in human HaCaT keratinocytes." J. of Dermatology Science.31, 65-71.
Mu X and Chang C (2003) "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3." The Prostate. 57,129-133.
Heinlein CA, and Chang C (2003) "Induction and Repression of Peroxisome Proliferator-Activated Receptor alpha (PPARa) Transcription by the Coregulator ARA70." Endocrine. 21, 139-146.
Cai Y, Dai T, Ao Y, Konishi T, chuang KH, Lue Y, Chang C and Wan Y (2003) "Cytochrome P450 gene are differentially expressed in female and male hepatocyte retinoid X receptor a-deficient mice." Endocrinology .144, 2311-2318.
Kang HY, Tsai MY, Chang C and Huang KE (2003) "Mechanisms and clinical relevance of androgens and androgen receptor action." Chang Gung Medical J. 26, 388-402.
Lee DK and Chang C. (2003) "Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication." Journal of Clinical and Metabolism of Endocrinology. 88, 4043-4954 .
Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Shin M, AozasaK, Okuyama A and Chang C (2003) "Modulation of androgen receptor transactivation by gelsolin: A new identified AR coregulator" Cancer Research. 63, 4888-4894.
Altuwaijri S, Lin HK, Chuang KH, Yeh S, Hanchett L, Zhang Y, Tsai MT, Yang L, and Chang C (2003) "Interruption of NFkB Signaling by Androgen Receptor Facilitates TPA-induce apoptosis in an Androgen Sensitive Prostate Cancer Cell Line." Cancer Research. 63, 7106-7112.
Fu M, rao M, Wang C, sakamaki T, Wang J, Vizio DD, Zhang X, Albanese C, Balk S, Chang C. Fan S, Rosen E, Palvimo J, Janne O, Muratoglu S, Avantaggiati ML and Pestell RG (2003) "Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth." MCB. 23, 8563-8573.
Yeh S, Hu YC, Wang PH, Xie C. Xu Q, Zhou X, Tsai MY, Dong Z, and Chang C. (2003) "Abnormal mammary gland development and growth retardation in breast cancer MCF7 cells and female mice lacking androgen receptor." J. Experimental Medicine 198, 1899-1908.
Ohtsu H, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee YF, Chen YT, Chang C, and Lee, KH. (2003) "Antitumor Agents 222. Synthesis and Anti-androgen Activity of New Diarylheptanoids." Bioorg Med Chem. 17, 5083-5090.
Lin H, Hu W, Yang L, Altuwaijri S, Chen YT Kang HY and Chang C (2003) "Suppression vs induction of androgen receptor by the PI3K/Akt pathway in prostate cancer LNCaP cells with different passage numbers." J. Biol. Chem 19, 50902-50907.
Collins L, Lee H, Chen YT, Yeh S and Chang C. (2003) "Androgen receptor in spermatogenesis" Cytogenetic and Genome Research 103, 289-301.
Miyamoto H, Rahman MM and Chang C (2004) "Molecular basis for the antiandrogen withdrawal symdrome" J. Cellular Biochemistry. 1, 3-12.
Wang PH and Chang C. (2004) "Androgens and ovarian cancers" Eu. J. Gynaec. Oncol. 25, 157-163.
Zhang Y, Yang Y, Yeh S and Chang C. (2004) "ARA67 functions as a repressor to suppress androgen receptor transactivation." MCB. 24, 1044-1057.
Hu YC, Wang PH, Hu YC, Yeh S, Xie C, Zhou X, Xu Q, Chao HT, Tsai MY, and Chang C. (2004) "Reduced fertility and defective ovulation in female mice lacking androgen receptor." Proc Natl. Acad. Sci. 101, 11209-11214.
Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH and Chang C (2004) "Androgen suppresses PML protein expression in prostate cancer CWR22R cells" BBRC 314, 69-75.
Heinlein CA and Chang C (2004) "Androgen receptor in prostate cancer." Endocrine Reviews. 25, 276-308.
Rahman M, Miyamoto H, and Chang C. (2004) "Androgen Receptor Coregulators in Prostate Cancer Progression: Mechanisms and Clinical Implications." Clinical Cancer Research.
Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Ken P and Chang C. (2004) "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells" MCB. 24, 2202-2213.
Litvinov I, Chang C and Isaacs J. (2004) "Molecular characterization of commonly-used human androgen receptor expression vector, pSG5-AR" The Prostate. 58, 319-324.
Miyamoto H, Messing E and Chang C (2004) "Androgen Deprivation Therapy for Prostate Cancer: Current Status and Future Prospects." The Prostate. 61, 332-353.
Chang C, Chen YT, Yeh SD, Xu Q, Guillou F, and Yeh S (2004) "Infertility with defective spermatogenesis and hypotestosteronemia in mice lacking androgen receptor in Sertoli cells." Proc Natl. Acad. Sci. 101, 6876-6881.
Xie S, Lin HK, Ni J, Wang L, Yang L, di Sant�Agnese PA, and Chang C (2004) "Regulation of interleukin-6 mediated P13K activation and neurendocrine diffrentiation by androgen signaling in prostate cancer LNCaP cells." The Prostate. 60, 61-67.
Mu X, Liu NC, Chen YT, Collins L, Kim E, Shyr CR, Lee YF and Chang C (2004)"Target inactivation of TR4 orphan receptor delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis" MCB. 24, 5887-5899.
Wang L, Lin HK, Hu YC, Mu X, Xie S, and Chang C (2004) "Glycogen Synthase Kinase 3b Negatively Regulates Androgen Receptor-Dependent Transcription and Cell Growth." JBC. 279, 32444-52.
Lin H, Hu W, Lee K and Chang C (2004) "Suppression of androgen receptor transactivation by PTEN tumor suppressor via protein degradation and nuclear translocation." Mol. Endo. 18, 2409-2423.
Hu YC, Yeh S, Yeh SD, Sampson E, Li P, Hsu CL, Ting H, Lin H, Wang L, Kim E and Chang C (2004) "Functional Domain and Motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer." JBC 279, 33438-46.
Ting HJ, Hu YC, and Chang C (2004) "Actin monomer enhances supervillin-modulated androgen receptor transactivation." BBRC 319,393-396.
Kang HY, Cho CL, Wang JC, Hu YC, Lin HK, Chang C and Huang KE (2004) "Nongenomic Androgen Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in MC3T3-E1 Osteoblasts." JBMR 19,1181-1190. (CC and HKE are co-correspondence author)
Collins L, Lee YF, Lin WJ, Heinlein CA, Liu NC, Chen YT, Chen Y, Shyr CR, Meshul CK, Uno H, Chou S, Platt KA and Chang C (2004) "Growth retardation and abnormal female maternity in mice lacking testicular orphan nuclear receptor 4." PNAS. 101. 15058-15063.
Altuwaijri S, Lee DK, Chuang KH, Ting HJ, Yang Z, Xu Q, Tsai MY, Yeh S, Hanchett LA, Chang HC and Chang C (2004) "Androgen receptor regulates expression of skeletal muscle specific proteins and muscle cell types." Endocrine. 25(1):27-32.
Lee Y, Bao B and Chang C (2004) "Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan receptor." BBRC. 323, 876-883.
Hsu CL, Chen YL, Lin WJ, Yang Z, Zhang Y, Ting HJ, Wang L, Wu CT, Chang HC and Chang C (2005) "Androgen receptor NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth."Mol Endo 19, 350-61.
Wang L, Hsu CL and Chang C (2005) "Androgen receptor corepressors: an overview." The Prostate 99, 1-14
Miyamoto H and Chang C (2005) "Hormonal therapy for prostate cancer: clinical and experimental evidence." pp 1-32. in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. (Chang C ed). World Scientific. USA.
Kim E, Yang Z, Liu B and Chang C (2005) "Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region." BBRC. 328, 85-90.
Chen YT, Collins LL, Uno H and Chang C (2005) "Deficits in Motor coordination with Aberrant Cerebellar Development in Mice Lacking Testicular Orphan Nuclear Receptor 4." MCB. 25, 2722-2732
Lin H, Xu Q, Yeh S , Wang RS, Sparks JD and Chang C (2005) "Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor." Diabetes.54, 1717-25.
Yang L, Xie S, Jamaluddin MS, Altuwaijri S, Ni J, Kim E, Chen YT, Hu YC, Wang L, Chuang KH, Wu CT, Chang C (2005) "Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells." JBC. 280(39):33558-65.
Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YY and Chang C (2005) "9-Cis-Retinoic Acid Inhibits Androgen Receptor Activity Through Activation of Retinoid X Receptor." Mol Endo. 19(5):1200-1212.
Wu C, Yeh S, Xu Q, Yang Z, Chang P, Yu Y, and Chang C (2005) "Study of androgen receptor roles in prostate cancer using mice lacking functional prostate androgen receptor" pp 223-238 in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. (Chang C ed). World Scientific. USA.
Miyamoto H, messing E and Chang C (2005) "Does androgen deprivation therapy improve treatment outcomes in patients with low- and intermediate-risk prostate cancer" Nature Clinical Patrice: Oncology. 2. 236-237.
Miyamoto H, Altuwaijri S, Cai Y, Messing E and Chang C (2005) "Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer." Mol Carcinogen. 44(1):1-10.
Fujimoto N, Chang C, Nomura M and Matsumoto T (2005) "Can we prevent prostate cancer? Rationale and current status of prostate cancer chemoprevention." Urol. Int. 74, 289-297.
Miyamoto H, Marwah P, Marwah A, Yang Z, Chung CY , Altuwaijri1 S, Chang C and Henry Lardy (2005) "Identification of steroid derivatives that function as potent antiandrogens" Int. J. Cancer: 117, 866-872.
Mu X, Yang L, and Chang C (2006) "Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis." BBRC. 341, 464-469.
Marwah P, Marwah A, Lardy H, Miyamoto H and Chang C (2006) "C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists" Bioorganic & Medical Chemistry. 14. 5933-5947.
Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'agnese PA, de Mesy-Bentley KL, Tzeng CR, and Chang C (2006)" Androgen Receptor in Sertoli Cell Is Essential For Germ Cell Nursery and Junctional Complex Formation in Mouse Testes" Endocrinology. 147(12):5624 -5633
Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tseng CR and Chang C (2006) "Differential Effects of Spermatogenesis and Fertility in Mice Lacking Androgen Receptor in Individual Testis Cells" PNAS . 103(50):18975-80
Zhang C, Yeh S, Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis C, Hu L, Lardy H and Chang C (2006) "Oligozoospermia with Normal Fertility in Male Mice Lacking the Androgen Receptor in Testis Peritubular Myoid Cells" PNAS. 103(47):17718-23.
Wang CP, Lee YF, Chang C and Lee HJ (2006) "Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor" BBRC. 351, 204 -208.
Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, Sant’Agnese A and Chang C (2006) "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth" Mol. Endo. 21(2): 343-58.
Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao YL, di Sant�Agnese PA, Tsai MY,and Chang C (2006) �Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonuleoprotein A1 via interaction with AR coregulator ARA54� Endocrinology. 148(3):1340-9.
Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Hu YC, Tsai MY, Yeh S, Messing E and Chang C (2007) "Androgen Receptor Signals Promote Bladder Cancer Development and Progression" JNCI, 99: 558-68.
Yang Z, Chang YJ, Yu IC, Miyamoto H, Wu CC, Yeh S, Merry DE, Sobue G, Chen LM and Chang C (2007) "ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor" Nature Medicine 13(3):348-353. This Nature Medicine Paper got over 50-newspapers reporting and 2-TV-stations interviewing. Click the following links to see those reports from English newspaper, Chinese newspaper and Taiwanese newspaper.
Zhang Y, Chen YT, Xie S, Wang L, Lee YF, Chang SS, and Chang C (2007)" Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain" Mol. Endo. 21(4):908-20.
Altuwaijri S, Wu CC, Niu YJ, Mizokami A, Chang HC, and Chang C (2007) "Expression of human AR cDNA driven by its own promoter results in mild promotion, but not suppression, of growth in human prostate cancer PC-3 cells" AJA. 9(2):181-8.
Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD. (2007) �Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4� EMBO. 2;26(9):2295-306.
Zheng Y, Chen Kl, Ma WL, Chang C, Ou JH (2007) "Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein." Virology, 5;363(2):454-61.
Yu SF, Cheng TT, Hsu YH, Lai HM, Chen YC, Chiu CK, Lin KM, Chang C, Chen CJ, Kang HY. (2007) "Association of tri-nucleotide (CAG and GGC) repeat polymorphism of androgen receptor gene in Taiwanese women with refractory or remission rheumatoid arthritis." Clin Rheumatol. 26(12):2051-8.
Wu CT, Altuwaijri S, Ricke WA, Huang SP, Yeh S, Zhang C, Niu Y, Tsai MY , and Chang C (2007) "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor" PNAS . 104(31):12679-12684
Chen YT, Collins LL, Uno H, Chou SM, Meshulf CK, Chang SS and Chang C (2007) "Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor" Brain Research, 1168:72-82.
Chen YT, Collins LL, Chang SS, Chang C (2007) "The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development" Cerebellum, 5(4): 1-9.
Kim ES, Ma WL, Lin DL, Inui S, Chen YL, and Chang C (2007) "TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression". BBRC. 361(2):323-8.
Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S and Chang C. (2007) "Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells." Endocrine 32:96�106.
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF and Chang C (2007) "Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase-Mediated Gluconeogenesis" Diabetes 56:2901-2909.
Hamalainen-Laanaya HK, Kobie JJ, Chang C and Zheng W (2007) "Temporal and Spatial Changes of Histone 3 K4 Dimethylation at the IFN-Gene during Th1 and Th2 Cell Differentiation" J. of Immunology 179: 6410-6415.
Zhao X, Zheng B, Huang Y, Yang D, Katzman S, Chang C, Fowell D and Zheng W (2007) "Interaction between GATA-3 and the Transcriptional Coregulator Pias1 Is Important for the Regulation of Th2 Immune Responses" J. of Immunology 179: 8297-8304.
Miyamoto H, Altuwaijri S and Chang C (2008) "Androgen Receptor in Prostate Cancer" pp 129-146 in Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies (Pestell R and Nevalainen ed)
Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC and Chang C. (2008) "Subfertility with Defective Folliculogenesis in Female Mice Lacking TR4 Orphan Nuclear Receptor" Mol Endo, 22(4):858-67.
Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S and Chang C. (2008) "Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue." Endocrinology. 149 (5): 2361-68.
Cai Y, Lee YF, Li G, Liu S, Bao BY, Huang J, Hsu CL and Chang C. (2008) "A new prostate cancer therapeutic approach: Combination of androgen ablation with COX-2 inhibitor" Int J Cancer. 123, 195–201.
Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S and Chang C (2008) "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor" Hepatology, 47(6):1924-35.

(Click here to view all publications; PDF files are available when you click indivudual publication)