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Faculty:

Dr. Shuyuan Yeh

Associate Professor of Urology and of Pathology and Laboratory Medicine

Click here for detail CV.

Email: Shuyuan_Yeh@urmc.rochester.edu

 

Dr. Shuyuan Yeh Publication (PDF files are available when you click individual poblication)

  • AR related

  1. Mizokami A, Yeh SY, Chang C. Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter. Mol Endocrinol. (1994) Jan;8(1):77-88.

  2. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci U S A. (1994) Jun 21;91(13):6040-4.

  3. Chang C, Saltzman A, Yeh S, Young W-J, Keller E, Lee H-J, Wang C, and Mizokami A "Androgen receptors: an overview." Critical Review in Eukaryotic Gene Expression,(1995), 5(2), 97-126.

  4. Ideta R, Yeh S, Lee YF, Adachi K, Takeda H, Su C, Saltzman A and Chang C "Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily." Endocrine,(1995), 3, 277-283.

  5. Yeh S and Chang C." Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A. (1996) ;93(11):5517-21.

  6. Yeh S, Miyamoto H, Chang C. "Hydroxyflutamide may not always be a pure antiandrogen". Lancet. (1997); 349(9055):852-3.

  7. Yeh S and Chang C. "ARA70, the first specific co-activator for the androgen receptor in human prostate cells." Worldwide Documents in Prostatic Cancer & BPH (1997). 5:2-3.

  8. Yeh S, and Chang C "The effect of androgens and 17b-estradiol on the androgen receptor transcriptional activity in the presence of the androgen receptor coactivator ARA70 in human prostate DU145 cells." from: Current Advances in Andrology (1997) (Waites G. Frick J and Baker G ed) pp. 17-22 Monduzzi Editore Italy.

  9. Miyamoto H, Yeh S, Fujimoto N, Hsiao P, Nishimura K, Hsu J, Ting H, Inui S, Chang C. "Androgen receptor and androgen receptor co-factors in prostate." Proc. Jap. Nat. Conf. Andrology. (1997),1-4.

  10. Yeh S, Miyamoto H, Shima H, Chang C. "From estrogen to androgen receptor: a new pathway for sex hormones in prostate". Proc Natl Acad Sci U S A. (1998); 95(10):5527-32.

  11. Miyamoto H, Yeh S, Wilding G, Chang C. "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc Natl Acad Sci U S A. (1998) ;95(13):7379-84.

  12. Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, Chang C. Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem Biophys Res Commun. (1998) ;248(2):361-7.

  13. Miyamoto H, Yeh S, Huang S, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C, Uemura H, Kang H, and Chang C "Androgen Receptor Coregulators: in: Molecular Basis of Sex Hormone Receptor Function "(1998), (Gornemeyer H, Fugymann U, and Parczyk ed) 43-53, Springer Berlin.

  14. Miyamoto H, Yeh S, Lardy H, Messing E, Chang C. "Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells". Proc Natl Acad Sci U S A. (1998) ;95(19):11083-8.

  15. Yeh S, Chang H, Miyamoto H, Takatera H, Rahman M, Kang H, Thin T, Lin D, and Chang C "Differential induction of androgen receptor transcriptional activity by selective androgen receptor coactivators." Keio J. of Medicine, (1999), 48, 87-92.

  16. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C. "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". J Biol Chem. (1999); 274(12):8316-21.

  17. Kang HY, Yeh S, Fujimoto N, Chang C. "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem. (1999) ;274(13):8570-6.

  18. Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C. "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc Natl Acad Sci U S A. (1999) ;96(10):5458-63.

  19. Heinlein CA, Ting HJ, Yeh S, Chang C. "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J Biol Chem. (1999) ;274(23):16147-52.

  20. Chang HC, Miyamoto H, Marwah P, Lardy H, Yeh S, Huang KE, Chang C. "Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells". Proc Natl Acad Sci U S A. (1999) ;96(20):11173-7.

  21. Nishimura K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh S, and Chang C "Yeast two-hybrid screening of associated proteins and characterization of mutant androgen receptors." (2000), 329-343 in Yeast Hybrid Technologies (Zhu L and Hannon G ed). Eaton Publishing.

  22. Yeh S, Kang HY, Miyamoto H, Nishimura K, Chang HC, Ting HJ, Rahman M, Lin HK, Fujimoto N, Hu YC, Mizokami A, Huang KE, Chang C. "Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells". Endocrine. (1999), (2):195-202.

  23. Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C. "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells". Proc Natl Acad Sci U S A. (2000); 97(21):11256-61.

  24. Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, Chang HC, Altuwaijri S, Huang KE, Chang C. "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". J Formos Med Assoc. (2000); 99(12):885-94.

  25. Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C. "From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells". Proc Natl Acad Sci U S A. (2001), 98(6):3018-23.

  26. Sampson ER, Yeh S, Chang HC, Tsai MY, Wang X, Ting HJ, Chang C. "Identification and characterization of AR associated coregulators in prostate cancer cells". J Biol Regul Homeost Agents. (2001), 15(2):123-9.

  27. Lin HK, Yeh S, Kang HY, Chang C. "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc Natl Acad Sci U S A. (2001), 98(13):7200-5.

  28. Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C. "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". J Biol Chem. (2001), 276(44):40417-23.

  29. Ting HJ, Yeh S, Nishimura K, Chang C. "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proc Natl Acad Sci U S A. (2002), 99(2):661-6.

  30. Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C. "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J Biol Chem. (2002), 277(7):4609-17.

  31. Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C. "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". J Biol Chem. (2002), 277(18):15426-31.

  32. Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C. Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. J Biol Chem.
    (2002), 277(39):36499-508.

  33. Sampson E, Yeh S. Miyamoto H, Lee DK, Tsi, MY, Wang X, Hsu CL, and Chang C "Interaction of cell cycle regulatory proteins with the androgen receptor." pp 223-238 in Steroid hormones and cell cycle regulation.(2002), (Burnstein KL ed). Kluwer, USA.

  34. Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC. "Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues". Proc Natl Acad Sci U S A. (2002), 99(21):13498-503.

  35. Wang MH, Yeh S, Su CY, and Young C. "Natural products and environmental androgens/antiandrogens" in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). (2003), Kluwer, USA.

  36. Rahman MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S, Chang C. "Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells". J Biol Chem. 2003 May 30;278(22):19619-26. Epub 2003 Mar 20.

  37. Hsu CL, Chen YL, Yeh S, Ting HJ, Hu YC, Lin H, Wang X, Chang C. "The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs". J Biol Chem. (2003), 278(26):23691-8.

  38. Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Miyamoto H, Shin M, Aozasa K, Okuyama A, Chang C. "Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator". Cancer Res. (2003), 63(16):4888-94.

  39. Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C. "Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells". Cancer Res. (2003), 63(21):7106-12.

  40. Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH, Chang C. "Abnormal Mammary Gland Development and Growth Retardation in Female Mice and MCF7 Breast Cancer Cells Lacking Androgen Receptor". J Exp Med. (2003), 198(12):1899-908.

  41. Collins LL, Lee HJ, Chen YT, Chang M, Hsu HY, Yeh S, Chang C. "The androgen receptor in spermatogenesis". Cytogenet Genome Res. (2003), 103(3-4):299-301.

  42. Zhang Y, Yang Y, Yeh S, Chang C. "ARA67/PAT1 functions as a repressor to suppress androgen receptor transactivation". Mol Cell Biol. (2004), 24(3):1044-57.

  43. Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C. "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells". Mol Cell Biol. (2004), 24(5):2202-13.

  44. Zhang M, Altuwaijri S, Yeh S. "RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness". Oncogene. (2004), 23(17):3080-8.

  45. Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H, Yeh S. "Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells" Proc Natl Acad Sci U S A. (2004), 101(18):6876-81.

  46. Hu YC, Wang PH, Yeh S, Wang RS, Xie C, Xu Q, Zhou X, Chao HT, Tsai MY, Chang C. "Subfertility and defective folliculogenesis in female mice lacking androgen receptor". Proc Natl Acad Sci U S A. (2004), 101(31):11209-14.

  47. Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. "Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer". J Biol Chem. (2004), 279(32):33438-46.

  48. Altuwaijri S, Lee DK, Chuang KH, Ting HJ, Yang Z, Xu Q, Tsai MY, Yeh S, Hanchett LA, Chang HC, Chang C. "Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types". Endocrine. (2004), 25(1):27-32.

  49. Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW, Chang C. "Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth". Mol Endocrinol. (2005), 19(2):350-61.

  50. Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD, Chang C. "Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor". Diabetes. (2005), 54(6):1717-25.

  51. Wu CT, Yeh S, Xu Q, Yang Z, Chang P, Hu Y, Chang C. "Study of Androgen-Androgen Receptor Roles in Prostate Cancer using Mice Lacking Functional Prostate Androgen Receptor" in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific Publishing: New Jersey, (2005), 383-92.

  52. 5Cai G, Huang H, Shapiro E, Zhou H, Yeh S, Melamed J, Greco MA, Lee P. "Expression of androgen receptor associated protein 55 (ARA55) in the developing human fetal prostate". J Urol. (2005), 173(6):2190-3.

  53. Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'Agnese PA, deMesy-Bentley KL, Tzeng CR, Chang C. "Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes". Endocrinology.(2006), 147(12):5624-33.

  54. Zhang C, Yeh S, Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis-Handagama C, Hu L, Lardy H, Chang C. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. Proc Natl Acad Sci U S A.(2006), 103(47):17718-23.

  55. Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tzeng CR, Chang C. "Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells". Proc Natl Acad Sci U S A.(2006), 103(50):18975-80.

  56. Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'agnese PA, Tsai MY, Chang C. "Suppression of Androgen Receptor Transactivation and Prostate Cancer Cell Growth by Heterogeneous Nuclear Ribonucleoprotein A1 via Interaction with ndrogen recepotr coregulator ARA54". Endocrinology, (2007), 148(3):1340-9.

  57. Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C."ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor". Nat Med. (2007), 13(3):348-53.

  58. Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, Yeh S, Messing EM, Chang C.Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. (2007), 99(7):558-68.

  59. Wu CT, Altuwaijri S, Ricke WA, Huang SP, Yeh S, Zhang C, Niu Y, Tsai MY, and Chang C "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor" Proc Natl Acad Sci U S A (2007)104(31):12679-12684

  60. Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S, Chang C. "Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells". Endocrine. (2007), 32(1):96-106.

  61. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. "Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue". Endocrinology. (2008), 149(5):2361-8.

  62. Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor". Hepatology. (2008), 47(6):1924-35.
  • Vit E and tocopherol associated protein

  1. Zhang Y, Ni J, Messing EM, Chang E, Yang CR, Yeh S. "Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells". Proc Natl Acad Sci U S A. (2002), 99(11):7408-13.

  2. Ni J, Chen M, Zhang Y, Li R, Huang J, Yeh S. "Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery". Biochem Biophys Res Commun. (2003), 300(2):357-63.

  3. Wu Y, Zu K, Ni J, Yeh S, Kasi D, James NS, Chemler S, Ip C. "Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention". Anticancer Res. (2004), 24(6):3795-802.

  4. Yeh S, Ni J, Chang E, Yin Y, Chen M. "Roles of Vitamin E in Prostate and Prostate Cancer" in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific Publishing: New Jersey, (2005), 263-76.

  5. Ni J Wen X, Yao J, Chang H, Yi Y, Xie S, Chen M, Di’Santagenese A, Messing EM and Yeh S. "Tocopherol associated protein inhibits the prostate cancer through inhibition of PI3 kinase pathway" Cancer Research, (2005), 65(21): 9807-16.

  6. Chang, E., Ni, J., Yin, Y., Chang, P., James, N., Chemler, S., and Yeh S. "a-Vitamin E derivative, a-tocpheryloxybutyric acid (TOB), inhibits the proliferation of prostate cancer cells". Asian J Androl. (2007), 9(1):31-39.

  7. Ni J, Pang ST, Yeh S. "Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells". Prostate;(2007), 67(5):463-471

  8. Yi Y, Ni J, Chen M, Gao Y, and Yeh S. "The Therapeutic and Preventive Effect of RRR-A-Vitamin E Succinate on Prostate Cancer via Induction of Insulin-Like Growth Factor Binding Protein-3" Clinical Cancer Research. (2007), 13(7): 2271-2280.

  9. Ni J and Yeh S. "The role of alpha-Vitamin and its Analogues in Prostate Cancer". Vitamin and Hormones. (2007), Volume 76, Chapter 19. Pp493-518

  • ER related

  1. Yeh S, Chen M, Ni J, Yin Y, Chang E, Zhang M, Wen X. "Functions of Estrogen Receptor in Prostate and Prostate Cancer" in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific Publishing: New Jersey, (2005), 293-313.

  2. Chen M, Ni J, Zhang Y, Muyan M and Yeh S "ERAP75 Functions as a Coactivator to Enhance Estrogen Receptor alpha Transactivation in Prostate Stromal Cells". Accepted. The Prostate. (2008) in press.

  3. Chen M, Ni J, Muyan M, Lin C-Y and Yeh S "ERAP75/CCDC62 Functions as a Coactivator to Enhance Estrogen Receptors Mediated Transactivation and Target Genes Expression in Prostate Cancer Cells". Submitted. Endocrinology, (2008).

  4. Chen M, Wolfe A, Wang X, Chang C, Yeh S* and Radovick S* "Generation and Characterization of a Complete Null ERalpha Mouse Using Cre/LoxP Technology". Submitted. Molecular and Cellular Biochemistry. (2008).

  5. Chen M, Hsu I, Wolfe A, Radovick S, Chang C, Messing E, M. and Yeh S "Defects of Prostate Development and Reproductive System in the ERalpha Null Male Mice", Revision. Endocrinology. (2008).

  6. Chen M, Huang KS, Wolfe A, Hsu I, Radovick S and Yeh S " Loss of Prostatic Ductal Morphogenesis in Mice Lacking Stromal Estrogen Receptor alpha". Endocrinology. (2008) (paper in preparation).

  • Other

  1. Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA. "Isolation of Ku70-binding proteins (KUBs)". Nucleic Acids Res. (1999). 27(10):2165-74.

  2. Li R, Ni J, Bourne PA, Yeh S, Yao J, di Sant'Agnese PA, Huang J. "Cell culture block array for immunocytochemical study of protein expression in cultured cells". Appl Immunohistochem Mol Morphol. (2005), 13(1):85-90.

 
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