Cardiovascular Function and Disease

• Atherosclerosis
• Heart Failure
• Lung Biology
• Cardiovascular Inflammation

The rapid advances in understanding the basic mechanisms responsible for normal function of the cardiovascular system have provided multiple approaches to study pathophysiology of cardiovascular disease. The overall goal of cardiovascular research is to understand how the cardiovascular system develops and responds to physiological and pathological changes. Understanding these processes will provide insight into new therapeutic approaches to treat diseases such as hypertension, coronary artery disease, atherosclerosis, stroke, myocardial infarction, and arrhythmias.

Abe, Jun-ichi
Mechanism and significance of kinase and transcriptional factors in diabetes-related cardiovascular disease.

Berk, Bradford C.
Molecular biology and genetics of cardiovascular disease.

Blair, Martha L.
Neural and neuroendocrine control of cardiovascular function.

Blaxall, Burns C.
Cardiac gene expression and G-protein coupled receptor signaling.

Brookes, Paul S.
Mitochondrial interactions with free radicals (nitric oxide, superoxide) in the context of myocardial ischemia reperfusion.

Davies, Mark G.
The role of G-protein signaling in smooth muscle cells following injury and during the development of atherosclerosis.

Dirksen, Robert T.
Calcium channel structure and function.

Fujiwara, Keigi
Molecular mechanism of mechano-signaling and response by endothelial cells, especially the role of cytoskeleton and intercellular adhesion molecules.

Hocking, Denise C.
Regulation of cell behavior by the extracellular matrix.

Jin, Zheng-Gen
Molecular regulation of vascular endothelial function and vascular diseases.

Lopes, Coeli M.B.
Molecular mechanisms of cardiac potassium channel regulation in health and disease.

Pryhuber, Gloria
Tumor necrosis factor alpha (TNF- a) signal transduction and subsequent gene regulation in pulmonary epithelium.

Rahman, Arshad
Signaling mechanisms of endothelial ICAM-1 expression and neutrophil-mediated lung vascular injury.

Rahman, Irfan
Oxidative stress, glutathione regulation, NF-kB, redox signaling and gene expression.

Sarelius, Ingrid H.
Vascular cell communication and signaling.

Sheu, Shey-Shing
Mitochondrial calcium signaling in normal and diseased heart cells and neurons.

Simpson-Haidaris, Patricia J.
Role of fibrinogen in acute phase response in pneumonitis and fibrinogen gene expression in liver and lung.

Smrcka, Alan V.
Molecular mechanisms of signal transduction.

Sottile, Jane
Molecular mechanisms by which the extracellular matrix controls cell behavior.

Waugh, Richard E.
Regulation and molecular basis of the mechanical stability of cells, cell membranes, and cell adhesion

Yan, Chen
Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system.

Yoon, Yisang
Cell biology of mitochondria: Regulation of mitochondrial dynamics.