Email this pageBottaro Lab
Andrea Bottaro, Ph.D.
Ph.D. 1987 Italy Non-Medical School
Associate Professor of Medicine
Division of Allergy/Immunology and Rheumatology
Research Overview
Dr. Bottaro's research interests include B cell activation, the molecular biology of antibody gene expression and reconbination, immunoglobulin class switching and trangenic/knock-out mouse models.
Recent Publications
Publication 1. View article in PubMed.
Publication 2. View article in PubMed.
Publication 3. View article in PubMed.
Publication 4. View article in PubMed.
Publication 5. View article in PubMed.
Igor Kuzin, M.D., Ph.D.
Ph.D. 1984 Institute Of Immunology, Russian Ministry of Health
Senior Instructor
Division of Allergy/Immunology and Rheumatology
Contact Information:
Igor Kuzin, M.D., Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-2180
Igor_Kuzin@urmc.
rochester.edu
Research Overview
Dr. Kuzin is currently working on two major research projects. The goal of the first one is to elucidate the mechanisms that regulate expression and recombination of immunoglobulin heavy chain (IgH) genes. Specifically, he and his are interested in the role of enhancer specificity in the IgH locus regulation. There are several enhancer elements within IgH locus. One of the best characterized is intronic Em enhancer, which plays a role in regulation of gene transcription, VDJ recombination, somatic hypermutation, and immunoglobulin class switching. In their studies, to address the role of enhancer specificity in the regulation of IgH locus activity, they have created transgenic mice bearing either a deletion of the Em core element or replacement of the same element with the strong, ubiquitous SV40 transcriptional enhancer. The phenotype of these transgenic mice is currently under investigation.
The goal of the second project is to develop an artificial in vitro system for the induction of antibody immune response by cultivated human lymphocytes. They use specially designed bioreactors in which human lymphocytes isolated from donor tonsils are propagated, and explore various conditions that would be optimal for the induction of primary and secondary antibody immune responses to a variety of antigens. These studies have potential clinical application.
Recent Publications
Publication 1. View article in PubMed.
Publication 2. View article in PubMed.
Publication 3. View article in PubMed.
Publication 4. View article in PubMed.
Contact
Andrea Bottaro, Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-2171
Andre_Bottaro@urmc.
rochester.edu
Lab Members
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Graduate Student |
