Critical Role of Cooperation Response Genes (CRGs) for the Cancer Phenotype

Project Overview

Our discovery that most of the CRGs we identified appear to be critical for the cancer phenotype provides us with the exciting opportunity to establish the entire cohort of CRGs, out of the 100-strong gene set, that is causally relevant to malignancy of colon cancer cells. We are performing comprehensive gene perturbation experiments in malignant murine and human cancer cells targeting all cooperation response genes for which a causative role for the cancer phenotype has not yet been established. The list of CRGs contains many genes with unknown functions and thus represents a considerable novel resource for cancer intervention.


Hartmut Land
University of Rochester
Box 633
601 Elmwood Ave.
Rochester, NY 14642
Office: MRB 2-9633