Email this pageGPR56 and TG2
Project Overview
Using a xenograft metastasis model, we have previously identified a novel G protein-coupled receptor, GPR56, as a suppressor of tumor growth and metastasis, and further discovered its ligand as TG2, a crosslinking enzyme in the extracellular matrix. To uncover the role of GPR56 and TG2 during metastasis, we will 1) study their involvement in endogenous tumor progression using GPR56-/- and TG2-/- mice; 2) study the involvement of GPR56 and TG2 in extracellular matrix assembly and its implication in tumor growth and metastasis, using the xenograft model; 3) study the signaling pathways through GPR56 using various biochemical tools.
Contact
Lei Xu
University of Rochester
Box 633
601 Elmwood Ave.
Rochester, NY 14642
Office: MRB 2-9645
+1-585-273-1302
lei_xu@urmc.rochester.edu
