McMurray Lab
Helene McMurray
Ph. D., 2004, University of Rochester, Department of Microbiology and Immunology
Assistant Professor of Genetics, Department of Biomedical Genetics (BMG)
Member, Center for Genomics and Systems Biology
Research Overview
The McMurray lab is focused on the systems biology of cancer cells. Much evidence shows that a complex set of changes takes place during cell transformation, corresponding to profound changes in cell behavior. Genomic analyses have begun to catalog these alterations, but little is known about how these differences in gene expression lead to malignant transformation. To address this question, we combine genomic and systems biology approaches coupled with genetics, cell and molecular biology to identify and understand cause-effect relationships within the complex network of gene alterations controlling the cancer cell. We believe that by exploiting differences in cancer vs. normal cell gene interaction networks, we can identify effective, cancer cell-specific intervention targets downstream of oncogenic mutations.
Projects
Cooperation response gene networks in prostate and breast cancer
Achieving cancer cell-specific growth inhibition via a CRG network
Recent Publications
McMurray HR; Sampson ER; Compitello G; Kinsey C; Newman L; Smith B; Chen SR; Klebanov L; Salzman P; Yakovlev A; Land H. Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature. 2008; 453(7198):1112-6. Epub 2008 May 25. View article in PubMed
McMurray HR; McCance DJ. Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7. Journal of virology. 2004; 78(11):5698-706. View article in PubMed
McMurray HR; McCance DJ. Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression. Journal of Virology. 2003; 77(18):9852-61. View article in PubMed
McMurray HR; Nguyen D; Westbrook TF; McAnce DJ. Biology of human papillomaviruses. International journal of experimental pathology. 2001; 82(1):15-33. View article in PubMed
Graduate Program Affiliations
Contact
Helene McMurray
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office: MRB 2-9634
+1-585-276-5235
helene_mcmurray@urmc.
rochester.edu
Lab Members
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Dorothy (DeeDee) Heyer, Technical Associate
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Pierre Candelaria, Postdoctoral Fellow |
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Anwesha Ghosh, Graduate Student |
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Jesse Llop, Research Programmer |
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Caressa Chen, Undergraduate Student |
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Simeng Wang, Undergraduate Student |
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Raluca Iorga, Volunteer |
Graduate students interested in a rotation should contact Dr. McMurray to determine current availability.
