Ph.D. 2005 University of Paris - 11 Orsay
Assistant Professor of Genetics, Department of Biomedical Genetics (BMG)
Research in the Biteau lab focuses on the molecular and cellular mechanisms that control tissue homeostasis and somatic stem cells. In order to retain their ability to contribute to tissue regeneration, stem cell populations have to maintain their self-renewal and pluripotency capacities, adapt their proliferation rate to the demand in differentiated cells and control the differentiation of their daughter cells. The precise regulation of these processes requires the integration of many signaling pathways. Deciphering how these pathways are regulated and coordinated is essential for our understanding of stem cell biology, as well as diseases, such as degenerative syndromes and cancer, and for the development of preventive and therapeutic strategies.
The recent identification of various adult stem cell populations in Drosophila melanogaster allows using the power of fly genetics to study these mechanisms. We use the fly intestine as a model to characterize new signaling pathways and factors regulating stem cell function, as well as their influence on tissue repair, aging and longevity.
The vast majority of the mechanisms that have been shown to control intestinal stem cell biology in Drosophila are evolutionary conserved, suggesting that our work will provide a conceptual framework to guide future studies in more complex model organisms, including humans.
Current projects in the laboratory use a combination of genetic, genomic and biochemical approaches to investigate new mechanisms that control cell fate decision in the intestinal lineage, stem cell quiescence and stem cell self-renewal.
A new signaling pathway controlling cell fate decision
We identified a new signaling pathway that regulates the balance between absorptive and endocrine cells in the intestinal epithelium. We found that endocrine cells secrete a factor that inhibits the commitment of progenitor cells to the endocrine lineage, resulting in a negative feedback. We are now exploring the molecular mechanisms that transduce this signaling in stems cell and control the expression of key fate determinants.
RNA stability and stem cell quiescence
We identified a protein that regulates RNA stability as an essential component of the complex mechanisms that control the balance between stem cell proliferation and quiescence. We are currently investigating the role of this activity in tissue repair and aging, and characterizing the specific targets that are regulated by this essential quiescence factor.
New transcription factors regulating stem cell biology
We recently performed a transcriptome analysis to identify evolutionary conserved transcription factors specifically expressed in Drosophila intestinal stem cells and early progenitors. We are now studying the function of these regulators using genetic and biochemical approaches.
Biteau B, Hochmuth C and Jasper H. (2011) “Maintaining tissue homeostasis: dynamic control of somatic stem cell activity.” Cell Stem Cell. 9(5):402-411. View article in PubMed.
Biteau B and Jasper H. (2011) “EGF signaling regulates the proliferation of intestinal stem cells in Drosophila.” Development. 138(6):1045-55. View article in PubMed.
Hochmuth C, Biteau B, Bohmann D and Jasper H. (2011) “Redox regulation by Keap1/Nrf2 controls intestinal stem cell proliferation in Drosophila.” Cell Stem Cell. 8(2):188-99. View article in PubMed.
DeGennaro M, Hurd T, Siekhaus D, Biteau B, Jasper H, Siekhaus D and Lehmann R. (2011) “Peroxiredoxin stabilization of DE-Cadherin promotes primordial germ cell adhesion.” Developmental Cell. 20(2):233-43. View article in PubMed.
Biteau B, Karpac J, Hwangbo DS and Jasper H. (2011) “Regulation of Drosophila lifespan by JNK signaling.” Exp. Gerontology. 46(5):349-54. View article in PubMed.
Biteau B, Karpac J, Supoyo S, DeGennaro M, Lehmann R and Jasper H. (2010) “Lifespan extension by preserving tissue homeostasis in Drosophila.” PLOS Genetics. 6(10):e1001159. View article in PubMed.
Biteau B and Jasper H. (2009) “It’s all about balance: p53 and aging.” Aging (Albany NY). 1(11):884-6. View article in PubMed.
Biteau B, Hochmuth C and Jasper H. (2008) “JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.” Cell Stem Cell. 3(4):442-55. View article in PubMed.
Nielsen MD, Luo X, Biteau B, Syverson K, and Jasper H. (2008) “14-3-3ε antagonizes Foxo function to control growth, stress tolerance and longevity in Drosophila melanogaster.” Aging Cell. 7(5):688-99. View article in PubMed.
Graduate Program Affiliations
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office: MRB 2-9613
We are happy to accept rotation students. Please contact Dr. Biteau for more information.
|Marc Nuzzo, laboratory technician|