Email this pageBohmann Lab
Dirk Bohmann
Ph.D. 1986 University of Tübingen
Professor of Genetics, Department of Biomedical Genetics (BMG)
Director, Graduate Cluster for Genetics, Genomics and Development (GGD)
Director, Center for Genomics and Systems Biology
Research Overview
The Bohmann lab uses Drosophila genetics, tissue culture approaches and biochemistry to model aging, cancer and metabolic regulation. Genetic, genomic, molecular and cell biological techniques are combined to achieve a systems level understanding of these complex processes.
Specific current projects include studies on JNK, Fos, Foxo and Nrf2 dependent signaling and gene regulation in oxidative stress response and aging. We are also working on signaling pathways that control malignancy in an in vivo cancer model. A recent focus of interest concerns the role of matrix metallo proteases in developmentally controlled as well as pathological cell movements and tissue invasiveness.
Projects
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JNK, Oxidative Stress and Aging |
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Nrf2 Signaling |
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Drosophila as a Cancer Model |
Recent Publications
Hyun, J., Bécam, I., Yanicostas, C. & Bohmann, D. (2006) Control of G2/M transition by Drosophila Fos. Mol. Cell Biol., 26, 8293-8302. View article in PubMed.
Uhlirova, M. & Bohmann, D. (2006) JNK and Fos regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J., 25, 5294–5304. View article in PubMed.
Sykiotis, G.P. & Bohmann, D. (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Developmental Cell, 14, 76-85. View article in PubMed.
More papers: 
Graduate Cluster Affiliations
Contact
Dirk Bohmann
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office: MRB 2-9639
+1-585-273-1446
dirk_bohmann@urmc.
rochester.edu
Lab Members
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