Ph.D. 1986 University of Tübingen
Professor of Genetics, Department of Biomedical Genetics (BMG)
Director, Center for Genomics and Systems Biology
The Bohmann lab uses Drosophila genetics, tissue culture approaches and biochemistry to model aging, cancer and metabolic regulation. Genetic, genomic, molecular and cell biological techniques are combined to achieve a systems level understanding of these complex processes.
Specific current projects include studies on JNK, Fos, Foxo and Nrf2 dependent signaling and gene regulation in oxidative stress response and aging. We are also working on signaling pathways that control malignancy in an in vivo cancer model. A recent focus of interest concerns the role of matrix metallo proteases in developmentally controlled as well as pathological cell movements and tissue invasiveness.
|JNK, Oxidative Stress and Aging|
|Drosophila as a Cancer Model|
Barone, M.C., Sykiotis, G.P. & Bohmann, D. (2011) Genetic activation of Nrf2
signaling is sufficient to ameliorate neurodegenerative phenotypes in a
Drosophila Parkinson's model. Disease Models and Mechanisms, 4, 701-707. View article in PubMed.
Sykiotis, G.P. & Bohmann, D. (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Developmental Cell, 14, 76-85. View article in PubMed.
Wang, Q., Uhlirova, M. & Bohmann, D. (2010) Spatial Restriction of FGF
Signaling by a Matrix Metalloprotease Controls Branching Morphogenesis.
Developmental Cell 18, 157–164. View article in Dev Cell
G. P. Sykiotis, D. Bohmann, Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease. Sci. Signal. 3, re3 (2010). View article in Science Signaling
Graduate Program Affiliations
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office: MRB 2-9639
|Andrew Pitoniak, Ph.D.|
|Julianne (Julie) Beaulieu|