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Bohmann Lab

Dirk Bohmann

Ph.D. 1986 University of Tübingen

Professor of Genetics, Department of Biomedical Genetics (BMG)

Director, Graduate Program for Genetics, Genomics and Development (GGD)

Director, Center for Genomics and Systems Biology

Research Overview

The Bohmann lab uses Drosophila genetics, tissue culture approaches and biochemistry to model aging, cancer and metabolic regulation. Genetic, genomic, molecular and cell biological techniques are combined to achieve a systems level understanding of these complex processes.

Specific current projects include studies on JNK, Fos, Foxo and Nrf2 dependent signaling and gene regulation in oxidative stress response and aging. We are also working on signaling pathways that control malignancy in an in vivo cancer model. A recent focus of interest concerns the role of matrix metallo proteases in developmentally controlled as well as pathological cell movements and tissue invasiveness.

Projects

JNK, Oxidative Stress and Aging
JNK, Oxidative Stress and Aging
Nrf2 Signaling
Nrf2 Signaling
Drosophila as a Cancer Model
Drosophila as a Cancer Model

Recent Publications

Barone, M.C., Sykiotis, G.P. & Bohmann, D. (2011) Genetic activation of Nrf2
signaling is sufficient to ameliorate neurodegenerative phenotypes in a
Drosophila Parkinson's model. Disease Models and Mechanisms, 4, 701-707. View article in PubMed.

Sykiotis, G.P. & Bohmann, D. (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Developmental Cell, 14, 76-85. View article in PubMed.

Wang, Q., Uhlirova, M. & Bohmann, D. (2010) Spatial Restriction of FGF
Signaling by a Matrix Metalloprotease Controls Branching Morphogenesis.
Developmental Cell 18, 157–164. View article in Dev Cell

G. P. Sykiotis, D. Bohmann, Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease. Sci. Signal. 3, re3 (2010). View article in Science Signaling

More papers: PubMed

Graduate Program Affiliations

 

Contact

Dirk Bohmann
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office: MRB 2-9639
+1-585-273-1446
dirk_bohmann@urmc.
rochester.edu

Lab Members

M C Barone

Cecilia Barone, Ph.D.

 

no photo
Andrew Pitoniak, Ph.D.
Nirmalya Chatterjee

Nirmalya Chatterjee

Christine Sommers

Christine Sommers

Xuan Li
Xuan Li
JB
Julianne (Julie) Beaulieu
Min
Min Tian
no photo
Yang Cheng