Canonical vs. noncanonical JAK/STAT signaling

Project Overview

Our recent studies in Drosophila have demonstrated a novel mode of signaling, which we termed “the non-canonical JAK/STAT pathway” (Shi et al., 2006; 2008). Currently, we are investigating the respective contribution of the canonical and non-canonical JAK/STAT pathways to cellular functions. We hypothesize that cooperation between the canonical and non-canonical JAK/STAT pathways can lead to dramatic changes in the epigenome (genome-wide chromatin modification patterns) and transcriptome (expression patterns of all genes) that are important for both normal development and pathogenesis.

Canonical vs noncanonical

 

Contact

Willis X. Li
University of Rochester
Box 633
601 Elmwood Ave.
Rochester, NY 14642
Office: MRB 2-9641
+1-585-273-2408

willis_li@urmc.
rochester.edu