Pröschel Lab

Christoph Pröschel

Ph.D. 1995 University College London

Assistant Professor of Genetics

Primary Appointment: Department of Biomedical Genetics (BMG)

Research Overview

Within the context of our work on glial progenitor cells, we are now focusing on the different stages of astrocytic differentiation and the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our recent discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy (Nat Med. 2005 Mar;11(3):277-83.). The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in genetic CNS disease paradigms, such as Vanishing White Matter leukodystrophy.

Projects

Recent Publications

Davies JE, Proschel C, Zhang N, Noble M, Mayer-Proschel M and Davies SA Transplanted astrocytes derived from BMP or CNTF treated glial restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol. 2008 Sep 19;7(7):24. View article in PubMed

Li, Z., Dong, T., Pröschel, C. and Noble, M. Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. (2007) PLoS Biology Feb, 5(2):35. View article in PubMed

Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. Astrocytes derived from glial-restricted precursors promote spinal cord repair. (2006) J Biol. Apr 27 5(3):7. View article in PubMed

More papers:

Graduate Cluster Affiliations

Genetics, Genomics and Development (GGD)

Contact

Christoph Pröschel
University of Rochester
Box 633
601 Elmwood Ave.
Rochester, NY 14642
KMRB 2-9629
Phone: (585) 273-5368
Fax: (585) 273-1450
chris_proschel@urmc.
rochester.edu

Lab Members

	Michelle Cooney Lacagnina
	Chung-Hsuan (Richard) Shih
	Matthew Mavissakalian