Jianwen Que
B.M. 1999 Beijing Medical University
Ph.D. 2005 National University of Singapore
Assistant Professor, Department of Biomedical Genetics (BMG)
Research Overview
Morphogenesis and stem cell biology of the esophagus
Research in the Que lab is focused on elucidating molecular and cellular mechanisms controlling proliferation and differentiation of esophageal stem/progenitor cells in the esophagus. We use a combination of cell biology, biochemistry and genetic studies with in vivo mouse models to address the issue. We believe that basic knowledge about the stem cell biology will yield important insights into clinical problems including esophageal agenesis in embryos and Barrett’s esophagus and cancer in adults. Together, these disorders place a substantial burden on the health care system.
Projects
| The transcription factor Sox2 for the homeostasis of the adult esophagus | |
| Signaling pathways for the maintenance of stem cell in the esophagus | |
| Other projects |
Recent Publications
Jovov B*, Que J*, Tobey NA, Djukic Z, Hogan BL, Orlando RC. Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease. Am J Gastroenterol. 2011 Mar 29. * equal contribution. View article in PubMed
Rodriguez, P., Silva, D. S., Oxburgh, L., Wang, F., Hogan, B. L. and Que, J. Bmp signaling in the development of the mouse esophagus and forestomach. Development. 2010 Dec;137(24):4171-6. Epub 2010 Nov 10. View article in PubMed
Romac J, Ohmuraya M, Bittner C, Majeed MF, Vigna SR, Que J, Fee B, Wartmann T, Yamamura K, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitior-1 rescues SPINK3 deficient mice and restores a normal pancreatic phenotype. Am J Physiol Gastrointest Liver Physiol. 2010; 298(4):G518-24. View article in PubMed
Li G, Luo R, Zhang J, Yeo K, Xie F, Tan E, Caille D, Que J, Kon Q, Salto-Tellez M, Meda P, Lim SK. Derivation of functional insulin-producing cell lines from primary mouse embryo culture. Stem Cell Research. 2009; 2:29–40. View article in PubMed
Que J, Luo X, Schwartz R, Hogan BL. Multiple roles for Sox2 in the developing and adult mouse trachea. Development. 2009;136(11). 1899-907. View article in PubMed
Rawlins EL, Okubo T, Que J, Xue Y, Luo X, Hogan BL. Lung epithelial stem cells in the development and repair. Cold Spring Harb Symp Quant Biol. 2008;73. 291-5. View article in PubMed
Que J, Wilm B, Hasegawa H, Wang F, Bader D, Hogan BL. Contribution of mesothelial cells to vascular smooth muscle and mesenchymal during lung development. PNAS. 2008;105(43):16626-30. View article in PubMed
Que J *, Okubo T *, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134(13):2521-31.* equal first authorship View article in PubMed
Que J, Lian Q El Oakley RM, Lim B, Lim SK. PI3K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines. J Mol Signal. 2007; 25;2:9. View article in PubMed
Que J, Choi M, Ziel JW, Klingensmith J, Hogan BL. Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation. 2006; 74(7):422-37. (Special Issue on organogenesis) View article in PubMed
Lian Q, Yeo K, Que J, Tan E, Yu F, Yin Y, Salto-Tellez M, Oakley RM, Lim SK. Establishing clonal cell lines with endothelial-Like potential from CD9, SSEA-1 cells in embryonic stem cell-derived embryoid bodies. PLoS ONE. 2006; 20;1:e6. View article in PubMed
Que J, El Oakley RM, Salto-Tellez M, Teh M, Lim SK. Co-culture of adult bone marrow cells with embryonic fibroblast feeder cells generates hybrid cell lines with endothelial potential. In Vitro Cell Dev Biol Anim. 2004; 40(5-6):143-9. View article in PubMed
Yin Y, Que J, Teh M, Cao WP, El Oakley RM, Lim SK. Embryonic cell lines with endothelial potential: an in vitro system for studying endothelial differentiation. Arterioscler Thromb Vasc Biol. 2004; 24(4):691-6. View article in PubMed
Graduate Program Affiliations
Contact
Jianwen Que
University of Rochester
601 Elmwood Ave., Box 633
Rochester, NY 14642
Office:KMRB 2-9615
office ph +1-585-273-4125
lab ph +1-585-273-4133
fax +1-585-273-1450
jianwen_que@urmc.
rochester.edu
Lab Members
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Post-doctoral Associate |
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Technical Associate |
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under-graduate student |
