Ph.D. 1994 Mount Sinai School of Medicine
Professor of Biomedical Genetics and Oncology
Department of Biomedical Genetics (BMG)
James P. Wilmot Cancer Center (JPWCC)
Center Affiliation: Center for Oral Biology (COB)
The primary interest of our lab is to study genetic regulatory circuits in development and disease. We use multidisciplinary approaches, including genetics & genomics, stem cell & development biology and protein chemistry & proteomics for our studies. Specifically, we investigate the development of tissue-specific precursor cells, including mesenchymal stem cells, trophoblast stem cells, neural progenitors and mammary stem cells, underlying the genetic networks in craniofacial morphogenesis, early embryonic and extraembryonic development, neural development and disorder, mammary development, and cancer.
Current projects focus on: The interplay of Wnt, FGF and BMP signaling pathways in determining the fate of craniofacial mesenchyme during skeletogenesis and craniosynostosis; mammary stem cells and progenitors in development and cancer; Gpr177/mouse Wls, a Wnt secretion regulator, in axial patterning; the role of SUMO-specific protease2 in cell cycle progression, polyploidy and aneuploidy; the SUMO pathway in motor neuron degeneration.
H-M Ivy Yu, Bo Liu, Shang-Yi Chiu, Frank Costantini and Wei Hsu (2005). Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci USA, 102, 8615-8620. View article in PubMed.
Bo Liu, H-M Ivy Yu and Wei Hsu (2007). Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of ß-catenin in proliferation and differentiation. Developmental Biology, 301, 298-308. View article in PubMed.
Chiu SY, Asai N, Costantini F, Hsu W (2008) SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages. PLoS Biology 6(12): e310 View article in PLoS Biology.
Sui Wang, Jan N Jensen, Philip A Seymour, Wei Hsu, Yuval Dor, Maike Sander, Mark A Magnuson, Palle Serup and Guoqiang Gu. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function (2009). Proc Natl Acad Sci USA, 106, 9715-9720. View article in PubMed
Ying Yan, Dezhi Tang, Mo Chen, Jian Huang, Jennifer H Jonason, Xiaohong Tan, David Reynolds, Wei Hsu, Stephen E. Harris, J Edward Puzas, Hani Award, Regis J O’Keefe, Brendan F Boyce and Di Chen. Axin2 controls bone remodeling through b-catenin-BMP signaling pathway in adult mice (2009). Journal of Cell Science, 122, 3566-3578. View article in PubMed
Jiang Fu, Ming Jiang, Anthony J Mirando, H-M Ivy Yu and Wei Hsu. Reciprocal regulation of Wnt and Gpr177/mouse Wntless is essential for embryonic axis formation (2009). Proc Natl Acad Sci USA [Epub ahead of print] PMID: 19841259 View article in PubMed
Maruyama T; Mirando AJ; Deng CX; Hsu W. The Balance of WNT and FGF
Signaling Influences Mesenchymal Stem Cell Fate During Skeletal
Development. Science signaling. 2010; 3(123):ra40. Epub 2010 May 25. View article in PubMed
Graduate Program Affiliations
University of Rochester Medical Center
601 Elmwood Ave., Box 611
Rochester, NY 14642
Office: KMRB G-9635
|H-M Ivy Yu, M.S.|
|Xian-Peng Ge, D.D.S., Ph.D.|