Biographical Sketch

Education

Ph.D., Statistics, 1994, Department of Statistics, Florida State University, Tallahassee, Florida USA

M.S., Statistics, 1991, Department of Statistics, Florida State University, Tallahassee, Florida USA

M.S., Engineering, 1987, Department of Automatic Control, National University of Defense Technology, P.R. China

B.S., Engineering, 1984, Department of Automatic Control, National University of Defense Technology, P.R. China

Positions and Appointments

2012-present. Founding Director, Center for Integrative Bioinformatics and Experimental Mathematics, University of Rochester School of Medicine and Dentistry, Rochester, NY

2011-present. Appointed as Dean’s Professor in recognition of my contribution in helping to shape the life of the institution in a significant way, University of Rochester School of Medicine and Dentistry, Rochester, NY

2006-2011, Co-Director, Biomedical Informatics Program, Clinical and Translational Science Institute (CTSI), University of Rochester Medical Center, Rochester, NY

2005-present, Director, Center for Biodefense Immune Modeling, University of Rochester Medical Center, Rochester, NY

2004-2012, Founding Chief, Division of Biomedical Modeling and Informatics, Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY

2004-present, Professor, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

2004-present, Professor, Department of Community and Preventative Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

2003-present, Professor, Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

2000-2003, Adjunct Lecturer, Department of Biostatistics, Harvard University, Boston MA, USA

2002-2003,Principal Research Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA, USA

1996-2002, Senior Statistical Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA, USA

1996-2002, Head, Pharmacology/Dynamic Modeling Section, SDAC/AACTG, Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA

1994-1996, Visiting Assistant Professor, Department of Mathematical Sciences, University of Memphis, Memphis, TN, USA

1989-1994, Teaching Assistant, Department of Statistics, Florida State University, Tallahassee, FL, USA

1987-1989, Engineer, Academy of Launch Vehicle Technology, Beijing , P.R. China

Awards and Honors

  • Best First-Year Student Award (1990), Department of Statistics, Florida State University
  • First Prize, Student Paper Awards, the 1993 Joint Statistical Meetings, San Francisco, Section on Statistics and the environment, American Statistical Association
  • The ENAR Student Paper Award, the 1994 Spring Meetings, Cleveland, Ohio, the Eastern North American Region of the Biometrics Society (ENAR)
  • Ralph A. Bradley Award (for the most outstanding Ph.D graduate), 1994, Department of Statistics, Florida State University (FSU)
  • The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association
  • Young Scientist Scholarship Fund Award, 1997, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, St. Petersburg, Florida
  • The First Independent Research Support & Transition (FIRST) Awards, 1998-2003, National Institutes of Health (NIH)
  • Young Scientist Scholarship Fund Award, 1998, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies, Lake Maggiore, Italy
  • Grant proposal review for Developmental Grants Program, Center for AIDS Research (CFAR), University of Washington, 2000
  • Grant proposal review for Dutch AIDS Fund, Amsterdam, Netherlands, 2001
  • Biocomputational Panel of the Information Technology Research Program, the National Science Foundation (NSF), 2003
  • Center Grant Reviewer, National Institute on Drug Abuse, National Institutes of Health (NIH), 2005
  • Grant proposal review for the section of Drug Discovery and Mechanisms of Antimicrobial Resistance, National Institutes of Health (NIH), 2005
  • Fellow, American Statistical Association, 2008
  • The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, 2009

Research Interests

  • Biomedical Big Data Analytics: Complex high-dimensional data from high-throughput technologies.
  • Statistical Methods and Theories for Differential Equation Models.
  • Computational Systems Biology and Bioinformatics: Genetic and protein network and multi-scale modeling.
  • Immunological Data Analysis and Modeling: Modeling immune response to influenza and HIV infection.
  • Biomathematical Modeling: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS epidemics.
  • Clinical Trials: Clinical trial design, pharmacokinetics and pharmacodynamics (PK/PD) study and Phase I trial design and modeling.
  • Longitudinal Data: Nonparametric regression methods and mixed-effects models.
  • Other Statistical Methodologies: High-dimensional variable selection, Markov chain Monte Carlo (MCMC), Bayesian methods, state-space models, measurement error models, missing data, and spatial statistics.