Anne Luebke - Current Research
CGRP deletion
CGRP deletion reduces auditory brainstem responses (ABRs) by a constant percentage at all suprathreshold sound levels. Panel A: ABR "thresholds" are determined by visual inspection of waveforms obtained at 5 dB increments in sound pressure level. Group means ( ± SEM) are plotted, and numbers of animals in each group are indicated in the key. Panel B: Mean ABR amplitude-vs. level functions for mutants and wildtypes are shown for two test frequencies (16 and 32 kHz), as indicated. Wave 1 of the ABR is defined as the earliest negative-positive deflection in the response waveform and corresponds to the summed activity of cochlear afferents. Panel C: Data from panel B are replotted to show the percent change in response amplitude, at each sound pressure level, due to the CGRP deletion. Only suprathreshold values are shown Panel D: Percentage decrease in response amplitude due to CGRP deletion is constant across ABR test frequency. Each point in this panel represents the mean value of a ?amplitude-vs.-level function such as shown in panel C.