Transplant-Related (Non-Relapse) Mortality Rates
Survival at 100 days post-transplant is a critical point followed by transplant centers to assess the quality of their transplant program. Similarly, transplant centers keep records of the causes of deaths of the patients transplanted at their centers. Deaths that are not caused by relapse or progression of disease are said to be "Transplant-Related." "Transplant-Related" deaths (mortality) within the first 100 days post-transplant are presumed to be due to the toxicities of the recipient's various pre-transplant therapies and/or the pre-transplant conditioning (chemotherapy, radiation) regimen.
The Advisory Board Company published 100 Day Transplant-Related Mortality benchmarks from the 2004 Oncology Roundtable of 5% for Autologous transplants, 20% for Allogeneic (Related Donor) transplants, and 40% for Allogeneic (Unrelated Donor) transplants. In this case the percentage of Transplant-Related mortality is a standard that transplant centers hope not to exceed. For example, if a transplant center performed 60 autologous transplants in a given year, their goal would be to have fewer than 3 deaths within the first 100 days post-transplant that were due to transplant-related toxicities and not due to relapse or progression of disease.
With few exceptions, the Wilmot Cancer Center's Blood & Marrow Transplant Program has met the goals established by these benchmarks.