4:00pm - 5:00pm|
Microbiology & Immunology Seminar Series
Co-Sponsored by the Developmental Center for AIDS Research (DCFAR)
Thomas C. Zahrt, Ph.D., Associate Professor of Microbiology and Molecular Genetics, Medical College of Wisconsin
Title: "Regulation of the Cell Envelope Stress Response Network in Mycobacterium tuberculosis by the MprAB Two-Component System"
Host: Martin Pavelka
Seminar Abstract: Mycobacterium tuberculosis is a pathogen of global significance, and is the causative agent of the human respiratory disease tuberculosis. In the vast majority of individuals infected, the bacterium establishes a persistent but asymptomatic infection that can last the lifetime of the host. A key aspect of M. tuberculosis survival during latency is the ability of the bacterium to recognize and resist cell envelope stressors that are encountered during long-term persistence with granulomatous lesions of the lung. I will discuss a key regulatory system, the MprAB two-component system, for its role in cell envelope stress resistance in M. tuberculosis. I will also describe how MprAB integrates with two other regulatory factors to collectively regulate the cell envelope stress response network in M. tuberculosis..
|Location: ||K-207 (Room 2-6408)|
Posted by: Corrine Aleese, Micro & Immunolgy, 7-Feb-13 11:27am ET