12:00pm - 1:00pm|
Microbiology & Immunology Seminar Series
Vanessa Sperandio, Ph.D., Professor of Microbiology and of Biochemistry, University of Texas Southwestern Medical Center
Title: Chemical signaling in bacterial/host interactions
Host: José Lemos & Michelle Dziejman
Research Abstract: Different chemical signaling systems shape bacterial/host relationships towards commensalism or pathogenesis. Enterohemorrhagic E. coli (EHEC) is a deadly food borne pathogen that causes hemorrhagic colitis worldwide. The main reservoir for EHEC is cattle herds. EHEC colonizes the recto anal junction (RAJ) of cattle, forming attaching and effacing (AE) lesions employing the locus of enterocyte effacement (LEE) genes. Additionally, EHEC also requires the glutamate acid resistance (gad) system to survive the acidic stomachs of these animals and successfully colonize the RAJ. Coordinated expression of the LEE and gad genes is achieved through SdiA, which is a transcription factor that functions as a receptor for acyl-homoserine lactones (AHL). Although E. coli (including EHEC) does not produce AHLs, they have the ability to respond to these signals through SdiA. SdiA senses AHLs produced by the rumminal microbiota affect LEE and gad expression through SdiAto promote EHEC's cattle colonization.
|Location: ||Ryan Case Method Room (1-9576)|
Posted by: Corrine Aleese, Micro & Immunolgy, 25-Sep-13 10:28am ET