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4:00pm - 5:00pm
Microbiology & Immunology Seminar Series
Co-Sponsored by the Allergy/Immunology and Rheumatology Division
Mariana Kaplan, M.D., Associate Professor of Internal Medicine, University of Michigan
Title: The role of neutrophil extracellular traps in the pathogenesis of systemic autoimmune diseases
Host: Jennifer Anolik
Research Abstract: Neutrophil extracellular traps (NETs) are released via a novel form of cell death called NETosis. NETs, consisting of a chromatin meshwork decorated with antimicrobial peptides, play an important role in the innate response to microbial infections. Recent evidence suggests that NETs may also promote deleterious autoimmune responses and directly damage tissues. Experimental evidence suggests that NETs participate in pathogenesis of autoimmune and inflammatory disorders. Indeed, exaggerated NETosis or diminished NET clearance likely increases risk of autoreactivity to NET components. This seminar will review and discuss the mechanisms of NET formation and putative role of NETosis in autoimmunity and organ damage, with a focus on systemic lupus erythematosus and rheumatoid arthritis.
http://www2.med.umich.edu/departments/Rheumatology/index.cfm?fuseaction=rheumatology.facultyBio&individual_id=43789&um_department=Internal%20Medicine
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| Location: | K-207 (Room 2-6408) |
Posted by: Corrine Aleese, Micro & Immunolgy, 7-Feb-13 11:09am ET
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