4:00pm - 5:00pm|
The Aab CVRI Seminar Series
SPEAKER:Catherine C. Hedrick, Ph.D.
Division of Inflammation Biology
La Jolla Institute for Allergy & Immunology
La Jolla, CA
TITLE OF TALK: Nuclear Receptors, Monocytes, and Inflammation
Dr. Hedrick's research is focused on understanding how cholesterol changes immune cell function in the artery wall to contribute to chronic disease, such as atherosclerosis. We are particularly interested in how immune cell function is changed in patients with diabetes, as type 1 and type 2 diabetes sufferers are four times more likely to die of a heart attack than the general population.
There are two main aspects to our research. One is studying how the cholesterol content of immune cells, such as T cells and monocytes, changes the phenotype and function of these cells to modulate atherosclerosis development. The second aspect of our research is to study the function of the NR4A family of nuclear receptors in atherosclerosis and other inflammatory diseases. We have recently discovered that one family member, NR4A1, is critically important for the development of a subset of monocytes in the bone marrow. We are exploring how NR4A1 regulates monocyte development, and how this nuclear receptor functions to regulate inflammation in chronic disease.
|Location: ||CVRI Conf. Room A105 - 211 Bailey Road, West Henrietta, NY|
Posted by: Jacqueline Velazquez, Cardiovascular Research Institute, 19-Sep-13 2:53pm ET