Email this pageWilliam J. Bowers, Ph.D.
Research
Inflammatory mechanisms underlying neurodegenerative disorders
The Bowers laboratory is interested in assessing the contribution of inflammation in the pathophysiology of Alzheimer's disease (AD). Novel transgenic mice and gene transfer-based methodologies are being employed to experimentally control the expression and/or activity of potent inflammatory cytokines/chemokines due to their purported role(s) in brain inflammation and neurodegeneration. The laboratory is also developing novel vaccines and therapeutics based upon the Herpes simplex virus (HSV) amplicon vector platform for future implementation in a clinical setting.
Recent Publications
Desai, M.K., K.L. Sudol, M.C. Janelsins, M.A. Mastrangelo, M.E. Frazer, and W.J. Bowers. 2008. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia, in press.
Bowers, W.J., S. de Silva, and H.J. Federoff. 2008. Gene therapy for neurological diseases. In: Gene Therapy: Therapeutic Mechanisms and Strategies. Ed. N.S. Templeton. 3rd ed. Taylor and Francis Group, New York, NY. In Press.
Frazer, M.E., J.E. Hughes, M.A. Mastrangelo, J.L. Tibbens, H.J. Federoff, and W.J. Bowers. 2008. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol. Ther. 16:845-853.
Duke, C.M.P., C.A. Maguire, M.C. Keefer, H.J. Federoff, W.J. Bowers, and S. Dewhurst. 2007. Heterologous vector prime boost incorporating the novel helper free herpes amplicon elicits a broad polyfunctional anti HIV T-cell response. Vaccine. 25:7410-7421.
Peterson, E.B., M.A. Mastrangelo, H.J. Federoff, and W.J. Bowers. 2007. Neuronal specificity of HSV/Sleeping Beauty amplicon transduction in uterois driven primarily by tropism and cellular co-factor expression profiles. Mol. Ther. 15: 1848-1855.
William J. Bowers, Ph.D.
Associate Professor
MRB 1-9637
(585) 273-2195
william_bowers
@urmc.rochester.edu
