Email this pageLaboratory Publications
2009
Park, K.M., D.I. Yule, and W.J. Bowers. 2009. Impaired TNF-α control of IP3R-mediated Ca2+ release in Alzheimer’s disease mouse neurons. Cell. Signal. In Press.
de Silva, S. and W.J. Bowers. 2009. Herpes virus amplicon vectors. Viruses. 1:594-629.
de Silva, S., M.A. Mastrangelo, L.T. Lotta, Jr., C.A. Burris, H.J. Federoff, and W.J. Bowers. 2009. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon vector platform. Gene Ther. In Press.
Fong, S., M.K. Chan, A. Fong, W.J. Bowers, and K.J. Kelly. 2009. Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells. Cancer Gene Ther. In Press.
Park, K.M., D.I. Yule, and W.J. Bowers. 2009. TNF-α mediated regulation of the inositol 1,4,5 triphosphate receptor promoter. J. Biol. Chem. 284:27557-27566.
Mastrangelo, M.A., K.L. Sudol, W.C. Narrow, and W.J. Bowers. 2009. Interferon-gamma differentially impacts Alzheimer’s disease pathologies and induces neurogenesis in triple transgenic-AD mice. Am. J. Path. 175:2076-2088.
Sudol, K.L., M.A. Mastrangelo, W.C. Narrow, M.E. Frazer, Y.R. Levites, T.E. Golde, H.J. Federoff, and W.J. Bowers. 2009. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer’s disease. Mol. Ther. In Press.
Bancos, S., Q.Y. Cao, W.J. Bowers, and I.N. Crispe. 2009. Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4. Cell. Immunol. 257:44-54.
Chiu, Y., W.J. Bowers, S.T. Lim, D.A. Ryan, and H.J. Federoff. 2009. Effects of HSV amplicon transduction on murine dendritic cells. Hum. Gene Ther. 20:442-452.
Fiandaca, M.D., V. Varenika, J. Eberling, T. McKnight, J. Bringas, P. Pivirotto, J. Beyer, P. Hadaczek, J. Forsayeth, W.J. Bowers, J. Park, H.J. Federoff, and K.S. Bankiewicz. 2009. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. NeuroImage. 47:T27-35.
Daubeuf, S., D. Singh, Y. Tan, H. Liu, H.J. Federoff, W.J. Bowers, and K. Tolba. 2009. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 113:3264-3275.
Desai, M.K., K.L. Sudol, M.C. Janelsins, M.A. Mastrangelo, M.E. Frazer, and W.J. Bowers. 2009. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. 57:54-65.
2008
Park, K.M., D.I. Yule, and W.J. Bowers. 2008. Tumor necrosis factor-alpha potentiates intraneuronal calcium levels via transcriptional regulation of the inositol 1,4,5-trisphosphate (IP3) receptor. J. Biol. Chem. 283:33069-33079.
Janelsins, M.C., M.A. Mastrangelo, K.M. Park, K.L. Sudol, W.C. Narrow, S. Oddo, F.M. LaFerla, H.J. Federoff, and W.J. Bowers. 2008. Chronic neuronal TNF-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am. J. Path. 173:1768-1782.
Mastrangelo, M.A. and W.J. Bowers. 2008. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic (3xTg-AD) mice. BMC Neurosci.9: 81.
Bowers, W.J., S. de Silva, and H.J. Federoff. 2008. Gene therapy for neurological diseases. In: Gene Therapy: Therapeutic Mechanisms and Strategies . Ed. N.S. Templeton. 3rd ed. Taylor and Francis Group, New York, NY. Pg. 833-868.
Bowers, W.J. M.C. Janelsins, and H.J. Federoff. 2008. Application to gene therapy and vaccination. In: Neuroimmune Pharmacology. Ed. T. Ikezu and H. Gendelman. Springer, New York, NY. Pg. 709-724.
Frazer, M.E., J.E. Hughes, M.A. Mastrangelo, J.L. Tibbens, H.J. Federoff, and W.J. Bowers. 2008. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol. Ther. 16:845-853.
Burris, C.A., S. de Silva, W.C. Narrow, A.E. Casey, L.T. Lotta, Jr., H.J. Federoff, and W.J. Bowers. 2008. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J. Gene Med. 10:152-164.
Nechushtan H., D. Pham, D. Morgensztern, K. Yi, S.U. Shin, H.J. Federoff, W.J. Bowers, K. Tolba, and J.D. Rosenblatt. 2008. Augmentation of antitumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother. 57:663-675.
2007
Yi, K.H., H. Nechustan, W.J. Bowers, H.J. Federoff, D.G. Pham, Y. Zhang, E.R. Podack, K.A. Tolba, and J.D. Rosenblatt. 2007. Adoptively transferred tumor-specific T cells expanded ex vivo using HSV amplicons encoding 4-1BBL show increased persistence and anti-tumor activity in vivo. Cancer Res. 67:10027-10037.
Duke, C.M.P., C.A. Maguire, M.C. Keefer, H.J. Federoff, W.J. Bowers, and S. Dewhurst. 2007. Heterologous vector prime boost incorporating the novel helper free herpes amplicon elicits a broad polyfunctional anti HIV T-cell response. Vaccine. 25:7410-7421.
Azadniv, M., K. Dugger, W.J. Bowers, C. Weaver, and I.N. Crispe. 2007. Imaging CD8 + T cell dynamics in vivo using a transgenic luciferase reporter. Int. Immunol. 19:1165-1173.
Peterson, E.B., M.A. Mastrangelo, H.J. Federoff, and W.J. Bowers. 2007. Neuronal specificity of HSV/Sleeping Beauty amplicon transduction in utero is driven primarily by tropism and cellular co-factor expression profiles. Mol. Ther. 15: 1848-1855.
Santos, K., C.M. Sanfilippo, W.C. Narrow, A.E. Casey, M. McDermott, H.J. Federoff, W.J. Bowers, and S. Dewhurst. 2007. Infectivity of Herpes Simplex Virus Type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. J. Virol. Meth. 145: 37-46.
Santos, K., D. Simon, E. Conway, W.J. Bowers, S. Mitra, T.H. Foster, A. Lugade, E. Lord, H.J. Federoff, S. Dewhurst, and J.G. Frelinger. 2007. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Hum. Gene Ther. 18: 1-13.
Sortwell, C.E., W.J. Bowers, S.E. Counts, M.R. Pitzer, S.O. McGuire, K.A . Maguire-Zeiss, H.J. Federoff, and T.J. Collier. 2007. Effects of ex vivo transduction of mesencephalic reaggregates with Bcl-2 on grafted dopamine neuron survival. Brain Res. 1134: 33-44.
Santos, K., C. Duke, S.M. Rodriguez, A. Dakwar, S. Fan, M.C. Keefer, H.J. Federoff, W.J. Bowers, and S. Dewhurst. 2007. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine.25: 1634-1646.
2006
Halterman, M.W., R.E. Giuliano, W.J. Bowers, and H.J. Federoff. 2006. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J. Gene Med. 8:1320-1328.
Bowers, W.J. and H.J. Federoff. Herpes simplex virus type 1-derived amplicon vectors. 2006. In: Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual. Ed. J. Rossi and T. Friedmann. Cold Spring Harbor Press, Cold Spring Harbor, NY. Pg. 227-254.
Tyler, C.M., C.A. Wuertzer, W.J. Bowers, and H.J. Federoff. 2006. HSV amplicons: Neuro Applications. Curr. Gene Ther. 6: 337-350.
Bowers, W.J. and H.J. Federoff. Immunotherapeutic approaches for Alzheimer's disease. 2006. In: Gene Therapy for Neurological Disorders. Ed. P. Lowenstein and M. Castro. Taylor and Francis, New York, NY. Pg. 197-227.
Bowers, W.J., M.A. Mastrangelo, H.A. Southerland, D.F. Howard, K.A. Maguire-Zeiss, and H.J. Federoff. 2006. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol. Ther. 13:580-588; editorial comment 13:457-458.
Arvanian, V.L., W.J. Bowers, A. Anderson, P.J. Horner, H.J. Federoff, and L.M. Mendell. 2006. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthen synaptic transmission in contused and staggered hemisected spinal cord of neonatal rat. Exp. Neurol. 197:347-352.
2005
Reinblatt, M., R.H. Pin, W.J. Bowers, H.J. Federoff, and Y. Fong. 2005. Viral delivery of a hypoxia-inducible soluble VEGF receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann. Surg. Oncol. 12:1025-1036.
Federoff, H.J. and W.J. Bowers. 2005. Immune shaping and the development of Alzheimer's disease vaccines. Sci. Aging Knowl. Environ. 2005(46): pe35.
Janelsins, M.C., M.A. Mastrangelo, S. Oddo, F.M. LaFerla, H.J. Federoff, and W.J. Bowers. 2005. Early correlation of microglial activation with enhanced TNF-alpha and monocyte chemoattractant factor expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J. Neuroinflammation. 2:23.
Corso, T.D., G. Torress, C. Goulah, I. Roy, A.S. Gambino, J. Nayda, T. Buckley, E. Stachowiak, E.J. Bergey, H. Pudavar, P. Dutta, D.C. Bloom, W.J. Bowers, and M.K. Stachowiak. 2005. Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods. Folia Morphol (Warsz). 64:130-144.
Corso, T.D., G. Torress, C. Goulah, I. Roy, A.S. Gambino, J. Nayda, T. Buckley, E. Stachowiak, E.J. Bergey, H. Pudavar, P. Dutta, D.C. Bloom, W.J. Bowers, and M.K. Stachowiak. 2005. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain Res. Mol. Brain Res. 139:361-366.
Gorantla, S., K. Santos, V.K. Meyer, S. Dewhurst, W.J. Bowers, H.J. Federoff, H.E. Gendelman, and L. Poluektova. 2005. Dendritic cell delivery of herpes simplex virus (HSV) amplicon vectors encoding HIV-1 gp120 elicits humoral and adaptive immunity, and viral protection in NOD/SCID mice engrafted with human immune cells. J. Virol. 79:2124-2132.
Bowers, W.J., M.A. Mastrangelo, H.A. Stanley, A.E. Casey, L.J. Milo, and H.J. Federoff. 2005. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: Differential antigen-specific immune responses . Neurobiol. Aging. 26:393-407.
2004
Wang, H., S.-W. Yu, M.F. Poitras, J. Lew, C. Coombs, W.J. Bowers, H.J. Federoff, G.G. Poirier, T.M. Dawson, and V.L. Dawson. 2004. Apoptosis Inducing Factor (AIF) substitutes for caspase executioners in N-methyl-D-aspartate triggered excitotoxic neuronal death . J. Neurosci. 24: 10963-10973.
Pin, R.H., M. Reinblatt, W.J. Bowers, H.J. Federoff, and Y. Fong. 2004. Amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. J. Gastrointest. Surg. 8: 812-822.
Arvanian, V.L., W.J. Bowers, J.C. Petruska, V. Motin, H. Manuzon, W.C. Narrow, H.J. Federoff, and L.M. Mendell. 2004. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. J. Neurophys. 92: 2394-2404.
Bowers, W.J. and H.J. Federoff. Gene therapy for neurological diseases. 2004. In: Gene Therapy: Therapeutic Mechanisms and Strategies , ed. N.S. Templeton. 2nd ed. Marcel Dekker, New York, NY. Pg. 601-627.
2003
Kyrkanides, S., J.H. Miller, W.J. Bowers, and H.J. Federoff. 2003. Dual transcription and post-translational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Mol. Ther. 8: 790-795.
Zhang, Y., Y. Hong, Y. Bounhar, E. Vereker, X. Roucou, M. Blacker, O. Tounekti, W.J. Bowers , H.J. Federoff, C. Goodyer, A. LeBlanc. 2003. p75 NTR protects primary cultures of human neurons against extracellular amyloid b -peptide cytotoxicity. J. Neurosci. 23: 7385-7394.
Harvey, B.K., C. Chang, Y. Chiang, W.J. Bowers , M. Morales, B.J. Hoffer, Y. Wang, and H.J. Federoff. 2003. HSV amplicon delivery of glial derived neurotrophic factor is neuroprotective against ischemic injury. Exp. Neurol. 183: 47-55.
Wang, X., R.D. Wiley, T.G. Evans, W.J. Bowers, H.J. Federoff, and S. Dewhurst. 2003. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 21: 2288-2297.
Olschowka, J.A., W.J. Bowers, S.D. Hurley, M.A. Mastrangelo, and H.J. Federoff. 2003. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol. Ther. 7: 218-227.
Bowers, W.J., J.A. Olschowka, and H.J. Federoff. 2003. Immune responses to replication-defective HSV-1 type vectors: implications for gene therapy. Gene Ther. 10: 941-945.
Snyder, J.E., W.J. Bowers, A.M. Livingstone, F.E.H. Lee, H.J. Federoff, and T.R. Mosmann. 2003. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nature Med. 9: 231-236.
2002
Tolba, K.A., W.J. Bowers , D.J. Eling, A.E. Casey, T.J. Kipps, H.J. Federoff, and J.D. Rosenblatt. 2002. HSV amplicon-mediated delivery of LIGHT enhances the antigen presenting capacity of chronic lymphocytic leukemia . Mol. Ther. 6: 455-463.
Tolba, K.A., W.J. Bowers , J. Muller, V. Housekneckt, R.E. Giuliano, H.J. Federoff, and J.D. Rosenblatt. 2002. HSV amplicon-mediated co-delivery of secondary lymphoid tissue (SLC) chemokine and CD40L results in augmented anti-tumor activity. Cancer Res. 62: 6545-6551.
Yu, S.-W., H.-M. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, G.G. Poirier, T.M. Dawson, and V.L. Dawson. 2002. Apoptosis Inducing Factor mediates poly(ADP-Ribose) polymerase-1 dependent cell death. Science. 297: 259-263.
Mankodi, A., M. Takahashi, H. Jiang, C. Beck, W.J. Bowers , R.T. Moxley, S. Cannon, and C. Thornton. 2002. Accumulation of poly(CUG) or (CCUG) RNA in the nucleus triggers aberrant splicing of chloride channel 1 pre-mRNA and chloride channelopathy in myotonic dystrophy. Mol. Cell. 10: 35-44.
Bowers, W.J. and H.J. Federoff. 2002. Amyloid immunotherapy-engendered CNS inflammation. Neurobiol. Aging. 23: 675-676.
Wang, S.W., X. Mu, W.J. Bowers, and W.H. Klein. 2002. Mouse retinal explants to study RGC differentiation. Methods. 28: 448-456.
Wang, S.W., X. Mu, W.J. Bowers, D-S. Kim, D.J. Plas, M.C. Crair, H.J. Federoff, L. Gan, and W.H. Klein. 2002. brn-3b-brn-3c double knockout mice reveal an unsuspected role for Brn-3c in retinal ganglion cell axon outgrowth. Development. 129: 467-477.
Halaby, I.A., S.P. Lyden, M.G. Davies, E. Roztocil, L.J. Salamone, A.I. Brooks, R.M. Green, H.J. Federoff, and W.J. Bowers . 2002. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Mol. Ther. 5: 300-306.
Hocknell, P.K., R. Wiley, X. Wang, T.G. Evans, W.J. Bowers, T. Hanke, H.J. Federoff, and S. Dewhurst. 2002. Use of a Herpes Simplex Virus-1 derived amplicon expressing Human Immunodeficiency Virus-1 gp120 results in potent, specific, and durable cellular and humoral immune responses in mice. J. Virol. 76: 5565-5580.
Detrait, E.R., W.J. Bowers, M.W. Halterman, R.E. Giuliano, L. Bennice, H.J. Federoff, and E.K. Richfield. 2002. The expression of reporter genes is toxic for primary cortical neurons and induces apoptosis. Mol. Ther. 5: 723-730.
Bowers, W.J., X. Chen, H. Guo, D.R. Frisina, H.J. Federoff, and R.D. Frisina. 2002. Neurotrophin-3 transduction attenuates ototoxicity in the aging mouse cochlea. Mol. Ther. 6: 12-18.
Maguire-Zeiss, K.A., W.J. Bowers, and H.J. Federoff. 2002. HSV amplicon vectors in neuronal apoptosis studies. In: Neuromethods, Vol. 37: Apoptosis Techniques and Protocols , ed. A. LeBlanc. 2 nd ed. Humana Press, Totowa, NJ. Pg. 61-82.
Maguire-Zeiss, K.A., W.J. Bowers, and H.J. Federoff. 2002. Somatic mosaic approaches and the aging brain. Neurobiol. Aging. 23: 977-984.
2001
Bowers, W.J., D.F. Howard, A.I. Brooks, M.W. Halterman, and H.J. Federoff. 2001. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 8: 111-120.
Jackson, M., W. Song, M.-Y. Liu, L. Jin, M. Dykes-Hoberg, C.-l. G. Lin, W.J. Bowers , H.J. Federoff, P.C. Sternweis, and J.D. Rothstein. 2001. Modulation of the EAAT4 glutamate transporter by novel interacting proteins, GTRAP41 and GTRAP48. Nature. 410: 89-93.
Chen, X., R.D. Frisina, W.J. Bowers, D.R. Frisina, and H.J. Federoff. 2001. Neurotrophin-3 transduction via helper-free HSV amplicon vector prevents mouse spiral ganglion neurons from cisplatin-induced damage. Mol. Ther. 3: 958-963.
Tolba, K., W.J. Bowers , S.P. Hilchey, M.W. Halterman, D.F. Howard, R.E. Giuliano, H.J. Federoff, and J.D. Rosenblatt. 2001. Development of HSV-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 98: 287-295.
Ballas, N., E. Battaglioli, E. Andres, F. Atouf, J. Chenoweth, M.E. Anderson, C. Burger, M. Moniwa, J. Davie, W.J. Bowers , H.J. Federoff, D.W. Rose, M.G. Rosenfeld, P. Brehm, and G. Mandel. 2001. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 31: 353-365.
Willis, R.A., W.J. Bowers , M.J. Turner, T.L. Fisher, C.S. Abdul-Alim, D.F. Howard, H.J. Federoff, E.M. Lord, and J.G. Frelinger. 2001. Dendritic cells transduced with HSV-1 amplicon vectors expressing prostate-specific antigen generate antitumor immunity in mice. Hum. Gene Ther. 12: 1867-1879.
Maguire-Zeiss, K.A., W.J. Bowers, and H.J. Federoff. 2001. HSV vector-mediated gene delivery to the CNS. Curr. Opin. Mol. Ther. 3: 482-490.
Bowers, W.J., K.A. Maguire-Zeiss, B.K. Harvey, and H.J. Federoff. 2001. Gene therapeutic approaches to the treatment of Parkinson's Disease. Clin. Neurosci. Res. 1: 483-495.
2000
Bowers, W.J., D.F. Howard, and H.J. Federoff. 2000. Discordance between expression and genome transfer titering of HSV amplicon vectors: Recommendation for standardized enumeration. Mol. Ther. 1: 294-299.
Brooks, A.I., D.A. Cory-Slechta, W.J. Bowers, S.M. Murg, and H.J. Federoff. 2000. Enhanced learning in mice parallels vector mediated NGF expression in hippocampus. Human Gene Ther. 11: 2341-2352.
1990's
Bowers, W.J., D.F. Howard, and H.J. Federoff. 1997. Gene therapeutic strategies for neuroprotection: implications for Parkinson's Disease. Exp. Neurol. 144 :58-68.
Baglia, L.A., W.J. Bowers, and A. Ruddell. 1997. The avian C/EBP gamma gene encodes a highly conserved leucine zipper transcription factor. Gene 190 :297-302.
Bowers, W.J. , L.A. Baglia, and A. Ruddell. 1996. Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interations. J. Virol. 70: 3051-3059.
Bowers, W.J. , J.F. Petrosino, C.D. Smith, and A. Ruddell. 1994. Transcriptional regulation of ALV bursal lymphomagenesis. Leukemia 8: S211-S213.
Bowers, W.J. , and A. Ruddell. 1992. a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer. J. Virol. 66: 6578-6586.
