Director, Center for Neurodegenerative & Vascular Brain Disorders
Director, Interdisciplinary Program in Dementia Research
Please see Director's Page for Dr. Zlokovic's research description.
- Rashid Deane is a Research Professor in the Center for Neurodegenerative and Vascular Brain Disorders. He received his BSc in Medical Physiology in 1974 at Bedford College, University of London and his PhD in Neuroscience in 1983 from St. Thomas’ Hospital Medical School (London) studying transport mechanisms across neurovascular barriers. Dr. Deane’s current research interests include studying (1) the control of the brain microenvironment in health and disease, (2) neuro-vascular concept of neurodegenerative diseases (Alzheimer's and prion disease),(3) neuro-vasculature as a potential target for disease-modifying therapies, such as LRP1, for Alzheimer’s and prion disease and (4) metal ions in Alzheimer's disease
- Dr. Huang Guo is a Research Assistant Professor in the Center for Neurodegenerative and Vascular Brain Disorders. She received her MD from Guangxi Medical University in Guangxi, China and her PhD in Neuroscience and Cell Biology from Tokai University School of Medicine, Japan. Dr. Guo’s research focuses on studying the molecular mechanisms of neurodegeneration induced by genetic mutations and environmental toxicants in Parkinson’s disease; with a particular emphasis on defining the signaling pathway mediating neurodegenerative processes include apoptosis, inflammation and blood-brain barrier dysfunction. Her research goal is to utilize activated protein C and its variants as a new therapeutic approach for treatment of Parkinson’s disease and other neuro-degenerative disorders. Dr Guo's experimental approach is to use both genetic and toxicant induced cell culture and mouse models of Parkinson’s disease.
Robert is a Research Assistant Professor working in the Center for Neurodegenerative and Vascular Brain Disorder. Along with defending his PhD in Pathology in 2010 at the University of Rochester he received the Wallace O. Fenn Award, named after the first Chairman of the Department of Physiology. This award is given annually to one graduating student judged to have completed especially meritorious research. His current interests are a continuation of his thesis work which focuses on the role of cerebral vascular dysfunction in the progression of neurodegenerative disorders, such as Alzheimer’s Disease. More specifically, he is working to elucidate how various genetic changes within cerebral vascular cells can lead to the accumulation of neurotoxins in the brain and exacerbate neurological disorders. In addition, he is continuing to work on the molecular mechanisms by which brain pericytes maintain normal cerebral perfusion and blood-brain barrier integrity necessary for proper neuronal structure and function.
- Ethan is currently a MD/PhD student in the Center for Neurodegenerative and Vascular Brain Disorders. He is currently studying the mechanisms through which a disrupted blood-brain barrier and pericyte loss may contribute to neurodegenerative processes, including Alzheimer's disease and amyotrophic lateral sclerosis. He is also studying the molecular mechanisms regulating transport of Alzheimer's disease amyloid-beta peptide across the blood-brain barrier.
Dr. Abhay P. Sagare is a Senior Instructor working in the Center for Neurodegenerative and Vascular Brain Disorders. Dr. Sagare received his Ph.D. in Biochemistry in 1997 from University of Pune, India and has conducted research in Alzheimer’s disease since 2001. He has shown that native soluble low-density lipoprotein receptor-related protein 1 (LRP1) normally controls 70-90% of the circulating neurotoxin amyloid-β (Aβ) in humans through peripheral binding, and is compromised in Alzheimer’s disease because of increased oxidation. Dr. Sagare is currently studying how apolipoproteins E and J regulate the levels of Alzheimer’s disease neurotoxin Aβ in the brain extracellular fluids, as well as its aggregation in brain parenchyma and the walls of cerebral blood vessels. His goal is also to validate oxidized sLRP as an early peripheral biomarker of Alzheimer’s disease.
Ekaterina Hatch is a Postdoctoral Fellow in the Center for Neurodegenerative and Vascular Brain Disorders. She received her PhD from the University of Utah in human genetics through the Molecular Biology Program.She works on developing novel transgenic overexpression and inducible mouse models to study mechanisms that govern neurovascular function. Recently, she has generated different transgenic animals in which LRP1 and RAGE are overexpressed in endothelial and vascular smooth muscle cells, utilizing Tie-2 and SM22 promoters respectively, to dissect tissue-specific roles of LRP1 and RAGE receptors at the blood-brain barrier and access their contribution to the Abeta accumulation in the brain. In addition, she has successfully designed a novel mouse line that utilizes a unique double promoter strategy allowing researchers to ablate pericytes in the adult mice.
Yaoming Wang is a Senior Research Associate working in the Center for Neurodegenerative and Vascular Brain Disorder. Dr. Wang received his MD/PhD in Neurology from Tongji Medical University in1999. His current research interests include: (1) The effects of protein C, protein S and growth factors on stroke, (2) Neurogenesis, angiogenesis and neuroprotective treatments after stroke utilizing novel treatments such as activated protein C, (3) Blood-brain barrier biology and (4) Amyotrophic lateral sclerosis
Itender Singh is a Senior Research Associate at the Center for Neurodegenerative and Vascular Brain Disorders. He received his MPhil and PhD degrees from the University of Delhi, India. Dr. Singh received his first postdoctoral training at the Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago. He unveiled the molecular mechanism that leads to disruption of the endothelial barrier in inflammatory diseases, particularly in Acute Respiratory Distress Syndrome (ARDS). Currently, Dr. Singh is pursuing his research interest in vascular biology of inflammatory diseases in the context of neurovascular dysfunction in neurodegenerative diseases, such as Alzheimer’s Diseases (AD). He is studying the effect of neurotoxins and hypoxia in cerebrovascular dysfunction and neuroinflammation. His research focus is to elucidate the cellular and molecular aspects of progressive neurovascular dysfunction that leads to neuroinflammation. In addition, Dr. Singh is also working on a disease-modifying therapy for AD by studying next-generation RAGE inhibitors and activated protein C using cellular and murine models of AD.
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