Goldman Lab

Current Projects

  • Molecular identification and gene expression analysis of phenotypically-restricted progenitor and glial cell types of both the fetal and adult human CNS
  • The relationship of native neural stem cells to tumor stem cells and gliomas of the adult CNS
  • Glial and oligodendrocyte progenitor-based cell therapy in models of pediatric leukodystophies.
  • Development of restricted neuronal progenitor cells for transplantation and drug development, such as those generating midbrain dopaminergic neurons
  • Use of both ES cell-derived and native progenitors in neurodegenerative diseases, including Parkinson’s, ALS, and MS
  • Inducing endogenous progenitors as a means of treatment, in particular in Huntington’s disease models

Recent Lab Publications

Bugiani M; Boor I; van Kollenburg B; Postma N; Polder E; van Berkel C; van Kesteren RE; Windrem MS; Hol EM; Scheper GC; Goldman SA; van der Knaap MS. "Defective glial maturation in vanishing white matter disease." Journal of neuropathology and experimental neurology. 2011; 70(1):69-82.

Goldman SA. "Progenitor Cell-Based Treatment of the Pediatric Myelin Disorders." Archives of neurology. 2011; Epub 2011 Mar 14.

Hertz, L., Lovatt, D., Goldman, S.A. Nedergaard, M. "Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and intracellular calcium". Neurochem Int.. 2010; 57(4): 411-420.

Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S.A., Nedergaard, M., Hertz, L., Peng, L. "5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'." Neuron Glia Biol.. 2010; 6(2): 113-125.

Wang, S., Chandler, D., Lu, G., Auvergne, R., Geschwind, D., Coppola, G., Nicolis, S., Sim, F., Goldman, S.A. "Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting." J Neurosci.. 2010; 30(44): 14635-14648.

Persson AI; Petritsch C; Swartling FJ; Itsara M; Sim FJ; Auvergne R; Goldenberg DD; Vandenberg SR; Nguyen KN; Yakovenko S; Ayers-Ringler J; Nishiyama A; Stallcup WB; Berger MS; Bergers G; McKnight TR; Goldman SA; Weiss WA. "Non-stem cell origin for oligodendroglioma." Cancer cell. 2010; 18(6):669-82.

Peng, W., Cotrina, M., Han, X., Yu, H., Bekar, L., Blum, L., Takano, T., Tian, G., Goldman, S., Nedergaard, M. "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury". Proc Natl Acad Sci U S A.. 2009; 106(30): 12489-12493.

Sim, F., Windrem, M., Goldman, S. "Fate determination of adult human glial progenitor cells". Neuron Glia Biol.. 2009; 5(3-4): 45-55.

Hartog, T.E., Dittrich, F., Pieneman, A., Jansen, R., Frankl-Vilches, C., Lessmann, V., Lilliehook, C., Goldman, S.A., Gahr, M. "BDNF signaling in the HVC is required for testosterone-induced song of adult female canaries". J Neurosci.. 2009; 29(49): 15511-15519.

Karumbayaram S; Kelly TK; Paucar AA; Roe AJ; Umbach JA; Charles A; Goldman SA; Kornblum HI; Wiedau-Pazos M. "Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS." Disease models & mechanisms. 2009; 2(3-4):189-95. Epub 2009 Feb 23.

Oberheim NA; Takano T; Han X; He W; Lin JH; Wang F; Xu Q; Wyatt JD; Pilcher W; Ojemann JG; Ransom BR; Goldman SA; Nedergaard M. "Uniquely hominid features of adult human astrocytes." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(10):3276-87.

Karumbayaram S; Novitch BG; Patterson M; Umbach JA; Richter L; Lindgren A; Conway AE; Clark AT; Goldman SA; Plath K; Wiedau-Pazos M; Kornblum HI; Lowry WE. "Directed differentiation of human-induced pluripotent stem cells generates active motor neurons." Stem cells (Dayton, Ohio). 2009; 27(4):806-11.

Goldman, S. "Neurogenesis in the adult songbird: A model for inducible striatal neuronal addition. In: Adult neurogenesis. F. Gage, G. Kempermann, eds. Cold Spring Harbor Press, 2008, pp. 593-618." In: Adult neurogenesis. F. Gage, G. Kempermann, eds. Cold Spring Harbor Press. 2008; : 593-618.

Kim DH; Lilliehook C; Roides B; Chen Z; Chang M; Mobashery S; Goldman SA. "Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(1):208-16.

Sim FJ; Lang JK; Ali TA; Roy NS; Vates GE; Pilcher WH; Goldman SA. "Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation." Glia. 2008; 56(9):954-62.

Windrem MS; Schanz SJ; Guo M; Tian GF; Washco V; Stanwood N; Rasband M; Roy NS; Nedergaard M; Havton LA; Wang S; Goldman SA. "Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse." Cell stem cell. 2008; 2(6):553-65.

Duncan ID; Goldman S; Macklin WB; Rao M; Weiner LP; Reingold SC. "Stem cell therapy in multiple sclerosis: promise and controversy." Multiple sclerosis (Houndmills, Basingstoke, England). 2008; 14(4):541-6.

Goldman SA; Schanz S; Windrem MS. "Stem cell-based strategies for treating pediatric disorders of myelin." Human molecular genetics. 2008; 17(R1):R76-83.

Goldman SA; Natesan S. "A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus." Cell stem cell. 2008; 3(2):125-6.

Goldman SA. "Interview. From canaries to the clinic." Regenerative medicine. 2008; 3(5):655-9.