Nedergaard Lab

Current Projects

  • The role of astrocytes in epileptogenesis and the treatment of seizure disorders
  • The contribution of astrocytes to the regulation of cerebral blood flow, especially in ischemia
  • Activity-dependent modulation of astrocytic signaling
  • The role of gliosis and glial signaling in stroke
  • Assessment of glial gene expression patterns in various disease states
  • Developing new modalities for imaging native and transplanted glial progenitors in vivo
  • Glial targeted treatment of spinal cord injury

Recent Lab Publications

Kasischke KA; Lambert EM; Panepento B; Sun A; Gelbard HA; Burgess RW; Foster TH; Nedergaard M. "Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011; 31(1):68-81. Epub 2010 Sep 22.

Thrane AS; Rappold PM; Fujita T; Torres A; Bekar LK; Takano T; Peng W; Wang F; Thrane VR; Enger R; Haj-Yasein NN; Skare O; Holen T; Klungland A; Ottersen OP; Nedergaard M; Nagelhus EA. "Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema." Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(2):846-51. Epub 2010 Dec 27.

Christensen DJ; Nedergaard M. "Two-photon in vivo imaging of cells." Pediatric nephrology (Berlin, Germany). 2011; Epub 2011 Mar 15.

Nedergaard M; Rodríguez JJ; Verkhratsky A. "Glial calcium and diseases of the nervous system." Cell calcium. 2010; 47(2):140-9. Epub 2009 Dec 31.

Nedergaard M; Verkhratsky A. "Calcium dyshomeostasis and pathological calcium signalling in neurological diseases." Cell calcium. 2010; 47(2):101-2. Epub 2010 Jan 15.

Hertz L; Lovatt D; Goldman SA; Nedergaard M. "Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i." Neurochemistry international. 2010; 57(4):411-20. Epub 2010 Apr 07.

Goldman N; Chen M; Fujita T; Xu Q; Peng W; Liu W; Jensen TK; Pei Y; Wang F; Han X; Chen JF; Schnermann J; Takano T; Bekar L; Tieu K; Nedergaard M. "Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture." Nature neuroscience. 2010; 13(7):883-8. Epub 2010 May 30.

Kang J; Kang N; Yu Y; Zhang J; Petersen N; Tian GF; Nedergaard M. "Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons." Neuroscience. 2010; 169(4):1601-9. Epub 2010 Jun 19.

Vates GE; Takano T; Zlokovic B; Nedergaard M. "Pericyte constriction after stroke: the jury is still out." Nature medicine. 2010; 16(9):959; author reply 960.

Zhang S; Li B; Lovatt D; Xu J; Song D; Goldman SA; Nedergaard M; Hertz L; Peng L. "5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'." Neuron glia biology. 2010; 6(2):113-25. Epub 2010 Sep 16.

Rempe DA; Nedergaard M. "Targeting glia for treatment of neurological disease." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2010; 7(4):335-7.

Kimelberg HK; Nedergaard M. "Functions of astrocytes and their potential as therapeutic targets." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2010; 7(4):338-53.

Wang X; Takano T; Nedergaard M. "Astrocytic calcium signaling: mechanism and implications for functional brain imaging." Methods in molecular biology (Clifton, N.J.). 2009; 489():93-109.

Takano T; Oberheim N; Cotrina ML; Nedergaard M. "Astrocytes and ischemic injury." Stroke; a journal of cerebral circulation. 2009; 40(3 Suppl):S8-12. Epub 2008 Dec 08.

Takano T; Nedergaard M. "Deciphering migraine." The Journal of clinical investigation. 2009; 119(1):16-9.

Hedley-Whyte ET; Goldman JE; Nedergaard M; Friedman A; Han X; Schmidt RE; Powers JM. "Hyaline protoplasmic astrocytopathy of neocortex." Journal of neuropathology and experimental neurology. 2009; 68(2):136-47.

Cotrina ML; Nedergaard M. "Physiological and pathological functions of P2X7 receptor in the spinal cord." Purinergic signalling. 2009; 5(2):223-32. Epub 2009 Feb 11.

Oberheim NA; Takano T; Han X; He W; Lin JH; Wang F; Xu Q; Wyatt JD; Pilcher W; Ojemann JG; Ransom BR; Goldman SA; Nedergaard M. "Uniquely hominid features of adult human astrocytes." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(10):3276-87.

Peng W; Cotrina ML; Han X; Yu H; Bekar L; Blum L; Takano T; Tian GF; Goldman SA; Nedergaard M. "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(30):12489-93. Epub 2009 Jul 27.

Rempe DA; Takano T; Nedergaard M. "TR(I)Pping towards treatment for ischemia." Nature neuroscience. 2009; 12(10):1215-6.