Core Center for Musculoskeletal Biology and Medicine

REQUEST FOR PROPOSALS: PILOT STUDIES

The University of Rochester Core Center for Musculoskeletal Biology and Medicine (URCCMBM) is requesting applications from new investigators for funding of pilot projects. Investigator-initiated pilot studies for full-time faculty who are either physician-scientists or research assistant professors and have not received NIH R01 or equivalent grant funding as Principal Investigator, are eligible to apply for research funding relevant to musculoskeletal diseases ($25,000 maximum for one year). An additional $25,000 matching grant will be awarded for research involving musculoskeletal cancer.

All principal investigators of proposals must be faculty members at the University of Rochester. Co-investigators may be from other institutions. Funding cannot be used to support faculty salary. Trainee salary support is permitted, but must be justified in the proposal. Renewal of funding of investigator-initiated pilots for a second year may be possible under special circumstances where considered justified, and revised applications from prior Requests for Proposals may be submitted. Concurrent funding of more than a single pilot award to an investigator from the URCCMBM is not permitted.

The pilot grant program is intended to provide seed funding to facilitate new research and future funding. Multidisciplinary research is strongly encouraged, as well as translational and clinical research that moves new discoveries along the translational continuum to humans and the community. Clinical and community based research, practice-based research, and health services research proposals are also encouraged.

Deadlines

Proposals must be received by March 1, 2013. Applicants will be notified of awards by May 1, 2013, which will be initiated immediately. The funding must be expended by June 30, 2014. Note: All animal and human subject protocols must be approved prior to the start date. No funds will be released until these approvals have been documented.

Background

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) recently awarded a Research Core Center (P30) in musculoskeletal biology and medicine to the University of Rochester. This URCCMBM provides shared facilities and services to groups of established, currently funded investigators addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and ensure greater productivity. It also awards pilot project grants to physician-scientists and research assistant professors who have not received NIH R01 or equivalent grant funding as Principal Investigator, for research aimed at improving the diagnosis, treatment and prevention of diseases and injuries of the musculoskeletal system and its component tissues. Key public health problems addressed by this research include, but are not limited to: osteoporosis; osteoarthritis;, and muscular dystrophies. The URCCMBM intends to combine and provide additional resources for research into these areas of human health.

The pilot funding will be targeted at research proposals which demonstrate ability to be catalytic in terms of generating new programs, directions, and funding for clinically applied research and methodologies. Priority will be given to eligible PIs who have received a favorable evaluation on a grant application that was not funded. These applicants are strongly encouraged to submit their Summary Statement/Critique together with their one-page abstract of their proposal.

Format for Proposal Submission

A face page application form is attached and should provide the following information:

(1) Title of the project;

(2) Investigators, with clear identification of PI and full contact information;

(3) Total amount of money requested;

(4) Indication as to whether the application is new or a revision of an unfunded

     grant proposal from any granting agency;

(4) A signed attestation statement that the project is not funded through another

     mechanism;

(5) IRB and UCAR status.

Submission

Proposals must be submitted electronically by email to Bonnie_Lipari@urmc.rochester.edu (phone: 585-273-5635). Please see the website or the necessary forms. Proposals will be in a modified NIH format with a six-page, 11-point font maximum. All proposals will contain Specific Aims and Background sections, and a section on: “Significance, opportunities for catalyzing new funding, and how the proposal is responsive to URCCMBM priorities.” These first three sections are limited to a total of two pages, and the remaining four pages will contain the Research Plan and Methods, a Potential Problems and Alternatives section, and up to a one-page maximum bibliography. No appendices or letters of support will be allowed, and all figures and tables must be contained within the body of the proposal. In addition, a detailed budget in NIH format is required (also attached). This does not count toward the six-page proposal limit. Revised versions of previously submitted applications that have not been funded may be resubmitted. Revised proposals may only be resubmitted one time. Revised applications may include a one-page maximum introductory statement responding to prior concerns.

Condition of Award

All awardees are required to attend an annual program meeting to provide input to improve the program, network with other awardees, and share project outcomes.

Contacts

If you have questions regarding this RFP, please contact one of the following:

General Inquiries:

Bonnie Lipari Bonnie_lipari@urmc.rochester.edu

(585) 273-5635

Scientific and Peer Review:

Edward Schwarz, PhD edward_schwarz@urmc.rochester.edu

Randy Rosier, MD PhD randy_rosier@urmc.rochester.edu

Richard Moxley III, MD richardt_moxley@urmc.rochester.edu

 

NIH Funding Acknowledgement ** Important ** All publications resulting from the utilization of CTSI resources are required to credit the CTSI grant by including the NIH FUNDING ACKNOWLEDGEMENT and must comply with the NIH Public Access Policy.