Novel Biostatistical and Epidemiologic Methods Program

Request Research Help

The principal goal of this program is to stimulate the development of novel biostatistical and epidemiologic methods that help overcome specifically identified limitations and significantly enhance the validity and accuracy, scope or speed of clinical or translational research. A high priority of the program is to facilitate novel cross-disciplinary collaborative research programs both within the Institution and externally. The pilot funding will be targeted at research proposals that demonstrate ability to be catalytic in terms of generating new programs, directions, and funding for methodologies with a clinical or translational component.

Click here to view the current RFA.   Abstracts are due September 15, 2014.  All applications require a signed attestation from the PI that the project is not funded through another mechanism.  Click here for a template for the PI attestation.

Eligible Research

The research should briefly but explicitly delineate how the intended project facilitates clinical or translational research, broadly defined. Crucial to a successful methodology proposal is its development within the context of solving a real problem in a relevant area of importance. Clinical research as defined by the NIH ( includes (a) patient-oriented research, (b) epidemiologic and behavioral studies, and (c) outcomes research and health services research.  A working definition of translational research (Rubio et al, 2010) includes: T1 research (“expedites the movement between basic research and patient-oriented research that leads to new or improved scientific understanding or standards of care”), T2 research (“facilitates the movement between patient-oriented research and population-based research that leads to better patient outcomes, the implementation of best practices, and improved health status in communities”) and T3 research (“promotes interaction between laboratory-based research and population-based research to stimulate a robust scientific understanding of human health and disease”). 

Review Priorities

Priorities for awarding pilot funding include:

  • Quality of the proposed science.
  • Potential impact on clinical and translational science, including how the proposed methodology will help to solve a real issue in an important area.
  • Potential to lead to or facilitate new funding.

A less important, but a possibly relevant priority is:

  • Interdisciplinary collaboration between investigators and trainees in different disciplines, to foster cross-bridging training and interaction.

Review Process

The 1-page abstracts are subjected to a preliminary review followed by a recommendation of which proposals should be solicited for full proposals.  The full proposals are then reviewed by researchers associated with another CTSA through a “swap” program, and funding recommendations are made to the CTSI Operations Committee for funding of the most meritorious projects. 

Click here to view CTSI Novel and Translational Methodologies Awardees and Projects.


NIH Funding Acknowledgement ** Important ** All publications resulting from the utilization of CTSI resources are required to credit the CTSI grant by including the NIH FUNDING ACKNOWLEDGEMENT and must comply with the NIH Public Access Policy.