Faculty Profiles
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Jun-ichi Abe, M.D., Ph.D.In the last four years, I have been interested in the mechanism of atherosclerosis and myocardial infarction, especially in the role of oxidative stress, hypoxia, and hyperglycemia. Read more>>> |
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Jeffrey Alexis, M.D.The research in my lab focuses on key signaling pathways involved in the development of transplant arteriopathy. Transplant arteriopathy is the leading cause of long term morbidity and mortality following heart transplantation. Read more>>> |
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Burns Blaxall, Ph.D.My general research interests focus on mechanisms regulating cardiac function and disease, beta-adrenergic receptors, the functional role of novel genes discovered by gene expression profiling of heart failure and their potential interactions with beta-adrenergic receptor signal transduction. Read more>>> |
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Jian Fu, Ph.D.Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor composed of a HIF a subunit and a b/ARNT subunit. While HIF b subunit is constitutively expressed, HIF a subunit is rapidly degraded at normoxia by the ubiquitin-proteasome pathway. Read more>>> |
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Keigi Fujiwara, Ph.D.Dr. Fujiwara’s major research is on mechanosignaling by vascular endothelial cells. Mechanical forces such as fluid flow and stretch trigger unique responses in endothelial cells, indicating that they are capable of sensing mechanical forces. Read more>>> |
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Zheng-Gen Jin, Ph.D.Dr. Jin’s research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only regulate vasomotor tone, but also the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis. Read more>>> |
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Slava Korshnuov, Ph.D.We have developed a flow-dependent model of vascular remodeling in mouse. In fact, this animal model significantly reproduced characteristics of human diseased arteries also called a “Glagov’s phenomenon”. Read more>>> |
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Bin Liu, M.D.Atherosclerosis is a major cause of death, morbidity and disability. Inflammation plays a key role in the development of atherosclerosis. Among inflammatory factors, monocyte chemoattractant protein-1(MCP-1 or CCL-2) has been shown to be critical in mediating atherosclerosis. Read more>>> |
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Coeli Lopes, Ph.D.Understanding the regulation of K+ channels by diverse G-protein signaling pathways in normal and pathological states. Read more>>> |
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Michael Massett, Ph.D.The overall focus of my research is to identify biological mediators of adaptations to exercise training that may provide insight into the prevention and treatment of cardiovascular disease. Read more>>> |
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Joseph M. Miano, Ph.D.Perturbations in programs of cellular differentiation underlie numerous human ailments. Within the vasculature, for example, smooth muscle cells (SMC) exhibit phenotypic plasticity in which their normal differentiated program is subverted to one of growth, migration, and matrix secretion. Read more>>> |
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Shi Pan, Ph.D.Reactive oxygen species (ROS) are generated in all aerobic organisms as the result of normal cellular metabolism. A balance of generating and neutralizing processes establishes the redox homeostasis, which is important for normal cell function. Read more>>> |
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Jane Sottile, Ph.D.Remodeling of extracellular matrices occurs during development, wound healing, and in a variety of pathological processes including atherosclerosis, ischemic injury, and angiogenesis. Read more>>> |
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James White, M.D., Ph.D.The overall goal of my fledgling laboratory is to understand the pathobiology which causes vascular remodeling in severe human pulmonary hypertension. Severe pulmonary hypertension (PH) occurs in idiopathic form and is also observed in diseases as diverse as chronic venous thromboembolism, scleroderma, HIV infection, and cirrhosis. Read more>>> |
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Chen Yan, Ph.D.Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. Second messenger cyclic nucleotides (cAMP and cGMP) regulate many signaling pathways in the cardiovascular system. For example, the vascular tone, smooth muscle cell growth, and cardiac muscle contractility are all regulated by cyclic nucleotide signaling. Read More>>> |