Endothelial cells maintain the integrity of the vasculature. In response to injury, endothelial cells undergo exocytosis, releasing the contents of granules into the blood stream, provoking inflammation and thrombosis.
We study how endothelial granules move inside cells, and how granules are connected to human disease. We defined the core machinery that mediates granule trafficking inside endothelial cells. Further, we discovered that nitric oxide regulates exocytosis by controlling the molecular motor of exocytosis. We then invented novel peptides that block exocytosis, in vitro and in vivo. Current research involves the identification of all proteins that regulate exocytosis in mammalian cells, and using human genetic studies to identify trafficking proteins that cause thrombosis and myocardial infarction in humans.
Charles J. Lowenstein, M.D.
University of Rochester
601 Elmwood Ave, Box CVRI
Rochester, New York 14642