Korshunov Lab
Vyacheslav (Slava) A. Korshunov, Ph.D.
| Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute |  |
2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy |
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| 1999 | Masters in Biology | Puschino State University, Pharmacology Group | |
| 1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy | |
Research Overview
Understanding of mechanisms that regulate the structure of blood vessels (a process we call “vascular remodeling”) could prevent cardiovascular morbidity and mortality in humans.
Projects
My laboratory research has two major directions:
First, we study the role of Axl, a receptor tyrosine kinase, in hypertension. We previously found that Axl significantly contribute to increases in blood pressure via promoting vascular dysfunction and remodeling in a salt-dependent mouse model of hypertension. It is now recognized that immune responses are important in hypertension. Axl is a very promising candidate that regulates both vascular and immune cells in hypertension (Fig. 1). Our studies will refine the current concept of the immune response in hypertension.
Second, we are utilizing a system biology approach to understand genetic mechanisms of the Glagov phenomenon. Originally described in atherosclerotic patients, Glagov phenomenon is a type of vascular remodeling that preserves the ability of blood to get through the artery. Currently, most of the clinical and experimental efforts are focused on the genetic effects on artery wall thickening. No data exist on the mechanisms that regulate the Glagov phenomenon in humans. We found that mouse genetic background contributes to dramatic variation in the Glagov phenomenon. For a given increase in wall thickening a physiological remodeling is non-stenotic (gray color), while pathological remodeling is stenotic (red color; Fig. 2). Our goal is to identify causal genes and key pathways that determine the Glagov phenomenon.
Therapeutic manipulation with vascular remodeling can be crucial for outcomes of cardiovascular diseases, such as heart attacks, strokes and peripheral artery diseases.
Recent Publications
- Immune modulation of vascular resident cells by axl
orchestrates carotid intima-media thickening., Gerloff J, Korshunov VA., Am J Pathol. 2012 May;180(5):2134-43.
- Novel tyrosine kinase signaling pathways: implications in vascular remodeling.
Batchu SN, Korshunov VA., Curr Opin Nephrol Hypertens. 2012 Mar;21(2):122-7. - Axl-dependent signalling: a clinical update., Korshunov VA., Clin Sci (Lond). 2012 Apr 1;122(8):361-8.
- Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress., Smolock EM, Korshunov VA., Vascul Pharmacol. 2010 Sep-Oct;53(3-4):185-92.
- Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB., Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC., Hypertension. 2010 Jul;56(1):105-11. Epub 2010 May 17.
More papers:
Contact
Vyacheslav (Slava) A. Korshunov, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, CVRI
Rochester, New York 14642
Admin. Office: (585) 276-9800
email
Lab Members
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Postdoctoral Research Associate |
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Laboratory Technician |
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Graduate Student |
