Korshunov Lab

Vyacheslav (Slava) A. Korshunov, Ph.D.

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute
Slava Korshunov
Associate Professor - Department of Biomedical Genetics (SMD)

2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy

1999 | Masters in Biology | Puschino State University, Pharmacology Group
1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy

Research Overview

Understanding the mechanisms that regulate the structure of blood vessels will decrease cardiovascular morbidity and mortality in humans. My current research focuses on immune mechanisms of cardiovascular disorders that affect vascular remodeling.


My laboratory research has three programs:Korshunuv Lab Image

  1. We are working on a project that explores the role of Axl, a receptor tyrosine kinase, in regulation of the immune responses in hypertension. Using state-of-the-art flow cytometry techniques we found that expression of Axl affected accumulation of leukocytes in the kidneys and determined pathogenesis of early phase of deoxycorticosterone-acetate and salt hypertension in mice. We showed that Axl regulates reactive oxygen species production in kidney’s leukocytes in hypertension (brown staining, Figure).
  2. We study genetic mechanisms that lead to differences between physiological and pathological carotid artery remodeling. We discovered a new candidate gene that regulates arterial rigidity and arterial stenosis; we are currently defining the pathway through which this novel gene regulates remodeling.
  3. We used a combined genetic approach of genome-wide linkage and association analyses to identify a novel locus on mouse chromosome 7 that controls elevated heart rate. We are studying candidate genes within chromosome 7 locus that control hemodynamic parameters and vascular inflammation

Recent Publications

  1. Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA. Role of Axl in early kidney inflammation and development of salt-dependent hypertension. Hypertension 2013;62(2):302-309
  2. Smolock EM, Burke R, Wang C, Batchu SN, Qiu X, Thomas T, Zettel M, Fujiwara K, Berk BC, Korshunov VA. Intima modifier locus 2 controls endothelial cell activation and vascular permeability. Physiol Genomics 2014;46(17):624-633
  3. Korshunov VA, Dyachenko IA, Murashev AN. Genetic determinants of heart rate variation and cardiovascular diseases (book chapter). IN: Genetic Disorders ISBN: 978-953-51-0886-3, InTech, Editor Dr. Maria Puiu. 2013;4:89-103. Available from: http://www.intechopen.com/books/genetic-disorders/genetic-determinants-of-heart-rate-variation-and-cardiovascular-diseases
  4. Korshunov VA. Arteriogenesis and collateral formation (book chapter). IN: PanVascular Medicine 2nd Edition ISBN: 978-3-642-37077-9 (Print) 978-3-642-37078-6 (Online) Editors: Lanzer, Topol; Section Editor: Carmeliet. 2015:167-189
  5. Theodorakis NG, Wang YN, Korshunov VA, Maluccio MA, Skill NJ. Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure. World J Gastroenterol 2015;21(14):4126-4135
  6. Batchu SN, Smolock EM, Dyachenko IA, Murashev AN, Korshunov VA. Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. J Am Heart Assoc 2015;4:e001952
  7. Batchu SN, Xia J, Ko KA, Doyley MM, Abe J, Morrell CN, Korshunov VA. Axl modulates immune activation of smooth muscle cells in vein graft remodeling. Am J Physiol Heart Circ Physiol 2015;309:H1048-H1058

NCBI Bibliography


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Vyacheslav (Slava) A. Korshunov, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, CVRI
Rochester, New York 14642
Korshunov Lab: (585) 276-7716

Lab Members

George Dugbartey

George Dugbartey

Postdoctoral Associate

Nergiz Ghafary

Nergiz Ghafary

Laboratory Technician