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Korshunov Lab

Vyacheslav (Slava) A. Korshunov, Ph.D.

Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute
2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy
1999 | Masters in Biology | Puschino State University, Pharmacology Group
1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy
	Korshunov profile

Research Overview

Understanding of mechanisms that regulate the structure of blood vessels (a process we call “vascular remodeling”) could prevent cardiovascular morbidity and mortality in humans.

Projects

My laboratory research has two major directions:

First, we study the role of Axl, a receptor tyrosine kinase, in hypertension. We previously found that Axl significantly contribute to increases in blood pressure via promoting vascular dysfunction and remodeling in a salt-dependent mouse model of hypertension. It is now recognized that immune responses are important in hypertension. Axl is a very promising candidate that regulates both vascular and immune cells in hypertension (Fig. 1). Our studies will refine the current concept of the immune response in hypertension.

Second, we are utilizing a system biology approach to understand genetic mechanisms of the Glagov phenomenon. Originally described in atherosclerotic patients, Glagov phenomenon is a type of vascular remodeling that preserves the ability of blood to get through the artery. Currently, most of the clinical and experimental efforts are focused on the genetic effects on artery wall thickening. No data exist on the mechanisms that regulate the Glagov phenomenon in humans. We found that mouse genetic background contributes to dramatic variation in the Glagov phenomenon. For a given increase in wall thickening a physiological remodeling is non-stenotic (gray color), while pathological remodeling is stenotic (red color; Fig. 2). Our goal is to identify causal genes and key pathways that determine the Glagov phenomenon.

Therapeutic manipulation with vascular remodeling can be crucial for outcomes of cardiovascular diseases, such as heart attacks, strokes and peripheral artery diseases.

Recent Publications

1. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN. Blood 2013 Apr 8. [Epub ahead of print].
2. G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration. Pang J, Xu X, Wang X, Wang J, Majumder S, Mohan A, Korshunov VA, Berk BC. Arterioscler Thromb Vasc Biol 2013;33:999-1005.
3. Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid. Smolock EM, Machleder DE, Korshunov VA, Berk BC. Arterioscler Thromb Vasc Biol 2013;33:1014-1019.
4. Genetic determinants of heart rate variation and cardiovascular diseases. IN: Genetic Disorders ISBN: 978-953-51-0886-3, Korshunov VA, Dyachenko IA, Murashev AN., InTech, Editor Dr. Maria Puiu. 2013;4:89-103. (book chapter) Available from: http://www.intechopen.com/books/genetic-disorders/genetic-determinants-of-heart-rate-variation-and-cardiovascular-diseases.
5. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation., Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC., Circulation 2012;126:2418-2427
6. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC.
   Mamm Genome. 2012 Oct;23(9-10):680-92.
7. Genetic locus on mouse chromosome 7 controls elevated heart rate.
   Smolock EM, Ilyushkina IA, Ghazalpour A, Gerloff J, Murashev AN, Lusis AJ, Korshunov VA.
   Physiol Genomics. 2012 Jul 3;44(13):689-98. Epub 2012 May 15.
8. Immune modulation of vascular resident cells by axl orchestrates carotid intima-media thickening., Gerloff J, Korshunov VA., Am J Pathol. 2012 May;180(5):2134-43.
   
9. Novel tyrosine kinase signaling pathways: implications in vascular remodeling.
   Batchu SN, Korshunov VA., Curr Opin Nephrol Hypertens. 2012 Mar;21(2):122-7.
10. Axl-dependent signalling: a clinical update., Korshunov VA., Clin Sci (Lond). 2012 Apr 1;122(8):361-8.

More papers:

Contact

Vyacheslav (Slava) A. Korshunov, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, CVRI
Rochester, New York 14642
Admin. Office: (585) 276-9800
email

Lab Members

	Sri Batchu Postdoctoral Associate
	Kathy Donlon Laboratory Technician