Berk Lab

Bradford C. Berk, M.D., Ph.D.

CEO, University of Rochester Medical Center - Department of Office of VP for Health Sciences (URMC)

Bradford Berk
Berk profile

Senior Vice President for Health Sciences - Department of Office of VP for Health Sciences (URMC)
Professor of Medicine, Department of Medicine, Cardiology
Professor of Pathology and Laboratory Medicine
Professor of Pharmacolgoy and Physiology
1981 | Ph.D. | Pharmacology | University of Rochester School of Medicine and Dentistry
1981 | M.D. | Medicine | University of Rochester School of Medicine and Dentistry
1975 | B.A. | Pre-Medical | Amherst College

Research Overview

Dr. Berk's laboratory has focused on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli. In particular the laboratory has studied the role of protein kinases as mediators of signal transduction in the vasculature.

Projects

The five major research projects ongoing in the laboratory include:

  1. Angiotensin II Signal Transduction – This project characterize the signal transduction events activated by angiotensin II focusing on determining the role of c-Src, Rho and the PDGF receptor in angiotensin II-mediated events.
  2. Fluid Shear Stress Signal Transduction in Endothelium – This project investigates the mechanisms by which steady laminar flow inhibits activation of JNK by TNF. The focus is on PKCzeta-mediated inhibition by flow.
  3. Oxidative Stress and Vascular Smooth Muscle Cell Growth – This project has characterized the mechanisms by which oxidative stress regulates smooth muscle growth.
  4. Genetics of Vascular Remodeling in Hypertension – The goal of this project is to identify genes that mediate vascular remodeling in response to changes in blood flow.
  5. Flow Responsive Mediators of Inflammation and Survival – These studies provide insight into mechanisms by which flow inhibits inflammation and facilitate development of therapeutic approaches to limit atherosclerosis.

Recent Publications

  1. Redox redux: protecting the ischemic myocardium., Spindel ON, Berk BC., J Clin Invest. 2012 Jan 3;122(1):30-2. doi: 10.1172/JCI61467. Epub 2011 Dec 27.
  2. Thioredoxin-Interacting Protein Mediates Nuclear-to-Plasma Membrane Communication: Role in Vascular Endothelial Growth Factor 2 Signaling. Spindel ON, Yan C, Berk BC. Arterioscler Thromb Vasc Biol; 2012, 32:1264-70.
  3. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC. Circ Res; 2012, 110:560-8.

  4. Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms. Spindel ON, World C, Berk BC. Antioxid Redox Signal; 2012, 16:587-96.
  5. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Bell RD,Winkler EA,Singh I, Sagare AP, Deane R,Wu Z, Holtzman DM, Betscholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Nature; 2012, 485:512-6.
  6. P62 binding to protein kinase C zeta regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells.  Kim, GY, Nigro, P, Fujiwara K, Abe JI, Berk BC. Arterioscler Thromb Vac Biol; 2012, Dec;32(12):2974-80.

  7. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Smolock E, Korshunov VA, Glazko G, Qui X, Gerloff J, Berk BC. Circulation. 2012 Nov 13;126(20):2418-27.

    More papers: PubMed

 

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Contact

Bradford C. Berk , M.D., Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 706
Rochester, New York 14642
Admin. Office: (585) 276-9800

Lab Members

Ryan Burke

Ryan Burke

Postdoctoral Associate

Amy Mohan

Amy Mohan

Senior Technical Associate

Elaine Smolock

Elaine Smolock

Research Assistant Professor

Mark Sowden

Mark Sowden

Research Associate Professor

Yingqian Xu

Yingqian Xu

Laboratory Technician

Chenjing Wang

Chenjing Wang

Postdoctoral Associate

Martha Zettel

Martha Zettel

Technical Associate