Korshunov Lab

Vyacheslav (Slava) A. Korshunov, Ph.D.

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute
Slava Korshunov
Associate Professor - Department of Biomedical Genetics (SMD)

2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy

1999 | Masters in Biology | Puschino State University, Pharmacology Group
1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy

Research Overview

Understanding of mechanisms that regulate the structure of blood vessels (a process we call “vascular remodeling”) could prevent cardiovascular morbidity and mortality in humans.

Projects

My laboratory research has three directions:  

  1. We are working on a project that explores the role of Axl, a receptor tyrosine kinase, in regulation of the immune responses in hypertension.
  2. We focus on new candidate genes that control elevated heart rate and vascular inflammation in response to stress.
  3. We study genetic mechanisms that lead to differences between physiological and pathological carotid remodeling.

Recent Publications

  1. Role of Axl in early kidney inflammation and progression of salt-dependent hypertension. Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA. Hypertension. 2013;62:302-309.
  2. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN. Blood. 2013 May 23;121(21):4417-27.
  3. Genetic determinants of heart rate variation and cardiovascular diseases. IN: Genetic Disorders ISBN: 978-953-51-0886-3, Korshunov VA, Dyachenko IA, Murashev AN., InTech, Editor Dr. Maria Puiu. 2013;4:89-103.
  4. Genetic locus on mouse chromosome 7 controls elevated heart rate. Smolock EM, Ilyushkina IA, Ghazalpour A, Gerloff J, Murashev AN, Lusis AJ, Korshunov VA. Physiol Genomics. 2012 Jul 3;44(13):689-98.
  5. Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening. Gerloff J, Korshunov VA. Am J Pathol. 2012 May;180(5):2134-43.

More papers:PubMed

 

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Contact

Vyacheslav (Slava) A. Korshunov, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, CVRI
Rochester, New York 14642
Admin. Office: (585) 276-9800
email

Lab Members

Kathy Donlon

Kathy Donlon

Laboratory Technician

Jixiang (Alex) Xia

Jixiang (Alex) Xia

Postdoctoral Research Associate