Korshunov Lab

Vyacheslav (Slava) A. Korshunov, Ph.D.

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute
Slava Korshunov
Associate Professor - Department of Biomedical Genetics (SMD)

2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy

1999 | Masters in Biology | Puschino State University, Pharmacology Group
1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy

Research Overview

Understanding the mechanisms that regulate the structure of blood vessels will decrease cardiovascular morbidity and mortality in humans. My current research focuses on immune mechanisms of cardiovascular disorders that affect vascular remodeling.

Projects

My laboratory research has three programs:Korshunuv Lab Image

  1. We are working on a project that explores the role of Axl, a receptor tyrosine kinase, in regulation of the immune responses in hypertension. Using state-of-the-art flow cytometry techniques we found that expression of Axl affected accumulation of leukocytes in the kidneys and determined pathogenesis of early phase of deoxycorticosterone-acetate and salt hypertension in mice. We showed that Axl regulates reactive oxygen species production in kidney’s leukocytes in hypertension (brown staining, Figure).
  2. We study genetic mechanisms that lead to differences between physiological and pathological carotid artery remodeling. We discovered a new candidate gene that regulates arterial rigidity and arterial stenosis; we are currently defining the pathway through which this novel gene regulates remodeling.
  3. We used a combined genetic approach of genome-wide linkage and association analyses to identify a novel locus on mouse chromosome 7 that controls elevated heart rate. We are studying candidate genes within chromosome 7 locus that control hemodynamic parameters and vascular inflammation

Recent Publications

  1. Role of Axl in early kidney inflammation and development of salt-dependent hypertension., Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA., Hypertension 2013;62(2):302-309.
  2. Axl-dependent signaling: a clinical update (Review), Korshunov VA.. Clin Sci (London) 2012;122:361-368.
  3. Novel tyrosine kinase signaling pathways: Implications in vascular remodeling (Review)., Batchu SN and Korshunov VA., Curr Opin Nephrol Hypertens 2012;21:122-127.
  4. Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening., Gerloff J and Korshunov VA., Am J Pathol 2012;180(5):2134-43.
  5. Korshunov VA. Apoptosis and vascular disease (Book chapter). IN: Modern Insights Into Disease From Molecules to Man. Apoptosis, Editor Victor R Preedy, 2010:327-340.
  6. Gas6-Axl pathway: The role of redox-dependent association of Axl with non-muscle myosin IIB., Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC., Hypertension 2010;56(1):105-11.
  7. Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress., Smolock EM and Korshunov VA, Vascul Pharmacol 2010;53(3-4):185-192.

More papers:PubMed

 

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Contact

Vyacheslav (Slava) A. Korshunov, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, CVRI
Rochester, New York 14642
Korshunov Lab: (585) 276-7716
email

Lab Members

Nergiz Ghafary

Nergiz Ghafary

Laboratory Technician