microRNA and Hypoxia

Project Overview

MicroRNA are short non-coding RNA species that regulate mRNA translation.  Hypoxia induces a set of microRNA that regulate the expression of proteins involved in angiogenesis and metabolism.  We have identified targets of microRNA that regulate hypoxia pathways.  For example, miR-107 controls expression of hypoxia-inducible factor -1ß (HIF-1ß) and modulates tumor angiogenesis. Current projects are studying microRNA expressed in endothelial cells that regulate metabolism, and microRNA in cancer cells that regulate proliferation.



Charles J. Lowenstein, M.D.
University of Rochester
601 Elmwood Ave, Box CVRI
Rochester, New York 14642