Biomathematical Modeling, Biostatistics and Bioinformatics Core
This core is an interdisciplinary core of biostatisticians, modelers, biocomputing scientists, software tool developers and bioinformaticians with expertise in various HIV/AIDS research areas. In addition to providing novel and standard statistical methods, this core seeks to support and collaborate with Investigators in the areas of grant proposal, study design and manuscript/abstract preparation.
Director: Hulin Wu, Ph.D.
This core additionally provides training through seminars and hands-on lab specific training and consultation. To request information or training please contact Hulin Wu, Ph.D.
Biostatistics
The Biostatistics Unit provides biostatistics support for design and analysis of HIV/AIDS-related in vitro and in vivo lab experiments, clinical studies, prevention/behavior studies and epidemiological and translational studies.
Biomathematical
The Biomathematical Unit seeks promote new multidisciplinary collaborations by providing modeling support to further HIV/AIDS-related research and to expand existing modeling efforts. Modeling expertise and projects include the following.
- PK/PD modeling of antiretroviral therapies
- HIV viral dynamics in AIDS clinical studies
- HIV viral fitness modeling for in vitro experiments
- AIDS epidemics modeling
- HIV RNA structure and sequence modeling
- Pathway modeling, cellular signaling and regulatory network modeling
- High-throughput data modeling and analysis
Biocomputing/Bioinformatics
The Biocomputing/Bioinformatics Unit provides translational data management and informatics services for HIV/AIDS-related research and studies, including the development of databases and data management, biocomputing and bioinformatics tools, and computational algorithms. Tools available include the following.
Latest Headlines
Starve a Virus, Feed a Cure?
Feb 2012 - A protein that protects some of our immune cells from the most common and virulent form of HIV works by starving the virus of the molecular building blocks that it needs to replicate, according to research published online in Nature Immunology. The finding comes from an international team of researchers including scientists from the University of Rochester Medical Center, NYU Langone Medical Center, several institutions in France – and a graduate student who is a political refugee from Africa and is now at work in a Rochester laboratory, intent on helping his people who have been devastated by the HIV epidemic.
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Scientists Explore Whether What Heals the Head Can Also Heal the Heart
A diverse group of scientists – experts in cardiology, neurology, immunology, microbiology and chemistry – are teaming up to study drugs that show promise in the treatment of dementia for the treatment of an equally debilitating disease – heart failure. In this case, the connection between the head and the heart lies in a particular enzyme that they believe plays a role in the development of both conditions.
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