Laboratory of Molecular Microbial Immunity

Recent Publications and Presentations

Invited speaker on AADR-Symposium - "Host Immunotherapeutic approaches for the treatment of periodontal diseases". Host: Dr. William Giannobile (University of Michigan, Ann Arbor, Michigan), Speakers: Drs. Tom Van Dyke, Keith Kirkwood, Andy Y-T. Teng. The AADR Annual Meeting, Dalllas, Texas, USA., April 2-5, 2008.

On the list of the invited speakers for the topic entitled: “The development and regulation of dendritic cells-derived osteoclasts” at "The 2nd International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems", to be held from 06/08-06/13, 2008, at Rhodes, Greece (http://www.aegeanconferences..org).

Invited seminar on: “Dendritic cells/T-cells interactions at the osteo-immune interface associated with osteoclastogenesis”, at the Dept. of Periodontology & Oral Health Sciences Research Seminar Series, School of Dentistry, University of Michigan, Ann Arbor. Date: Winter 2007-2008, Host: Dr. Keith Kirkwood, University of Michigan. 33. Symposium speaker of the IADR-Symposium - "Osteoimmunology and Host Defense in the Periodontium". Organizer & Host: Dr. Andy Y-T. Teng (University of Rochester, Rochester, New York), Symposium speakers: Drs. Ulf Lerner (Sweden), Marty Taubman (USA), Hiroyuki Kanzaki (Japan) and Andy Y-T. Teng (USA). The AADR Annual Meeting, Toronto, Canada, July 4-7, 2008.

International Periodontal Symposium”, Taiwan, Mar 10-11, 2007. Host: Dr. Ming-Yung Chou, Dean of the College of Dental Medicine, Chung-Shang Medical University (CSMU), Tai-Chung, Taiwan, R.O.C.

Invited speaker for BIT the 5th “The Congress of International Drug Discovery Science and Technology” - IDDST -: 05/28/07 – 06/04/07, Shanghi, China, Co-chair session #9 “Vaccines and inflammatory disease drug discovery & development” Seminar topic: “Cytokines regulation in human aggressive periodontitis”

Invited keynote seminar entitled “Therapeutic single-chain sc-Fv monoclonal antibody for human periodontal disease”. Association of Dental Sciences - (ADS-ROC) Annual Research Meeting, Taipei, Taiwan, Nov 16-18, 2007.

Keynote seminar entitled: “Innate & adaptive immunity and bone loss”. College of Dental Medicine, Dean’s invitation speech. Host: Dr. Chi-Cheng Tsai, Koashiung Medical University, Kaoshiung, Taiwan. Mar 29, 2006.

Invited seminar: “Dendritic cells-derived osteoclasts and inflammation-induced bone loss”, Rochester Institute of Technology, Dept. of Chemistry; Dept. Seminar Series. Host: Dr. Tom Smith; April 18, 2006.

Group-sponsored special symposium at IADR 2006 Annual Meeting, Brisbane, Australia; - “Oral Mucosal Immune Responses in Health and Disease”, Speakers: Drs. Derek Hart (Sidney, Australia), Christopher W Cutler (Stony Brook, NY, USA), Martin Taubman (Harvard, MA, USA), Greg G. Seymour (Bristbane, Australia) and Andy Y-T. Teng (Rochester, NY, USA).

Invited keynote seminar: “Innate vs. adaptive immunity and periodontal bone loss: Interactions between dendritic cells, RANKL-RANK signaling & T-helper cells”. Association of Dental Sciences - (ADS-ROC) Annual meeting, Tai-Chung, Taiwan, Aug. 24-27, 2006, Taiwan.

Oral presentation: “The interrelationship between oral health and cardiovascular disease” by A Y-T. Teng., Bath VA Hospital, Clinical Conference and Continuing Professional Education, Scheduled for Sept. 28, 2006. Host: Bath VA Hospital, Rochester, NY & University of Rochester, School of Medicine and Dentistry.

Invited seminar: “Programming the innate vs. adaptive immunity and periodontal bone loss in vivo: Linking dendritic cells, RANKL-RANK signaling & T-helper cells”. Hosts: Drs. Thomas Flemmig & Frank Roberts, Dept of Periodontology & Oral Biology, University of Washington, Oct. 02-04, 2006.

Differential Detection of the 16s-rDNA from Periodontal Pathogens by Multiplex PCR. Doughlas P. Baley and Andy Y-T. Teng. Submitted, 2005.

Apototic activity and sub-cellular localization of a T4SS-associated CagE-homologue in Actinobacillus actinomycetemcomitans. Andy Y-T. Teng & Xiaoxia Zhang, Microbial Pathogenesis -(short communication)- 38(2-3):125-32, 2005.

G(-) Anaerobes-reactive CD4+T cells Trigger RANKL-mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice. Deeqa A. Mahamed, Annette Marleau, Mawadda Alnaeeli, Bhagirath Singh, Xiaoxia Zhang, Joseph M. Penninger and Yen-Tung A. Teng. Diabetes 54:1477-1486, 2005.

CD11c+ Dendritic Cells Develop into Functional Osteoclasts During the Immune Interactions with CD4+ T-cells in the Bone Environment. Mawadda Alnaeeli, J. M. Penninger, and Andy Y-T. Teng, Submitted. 2005.

IFN-gamma positively modulates Actinobacillus actinomycetemcomitans-specific CD4+T cells-mediated alveolar bone destruction in vivo. Yen-Tung A. Teng, Deeqa Mahamed & Bhagirath Singh. Infect. & Immunity. 73(6):3453-61., 2005.

Protective and destructive immunity in the periodontium: (Part 1) - Innate and humoral immunity and the periodontium. Invited review: Teng Y-T A., J. Dent. Res. In press, July 2005.

Protective and destructive immunity in the periodontium: (Part 2) - T-cell-mediated immunity in the periodontium. Invited review: Teng Y-T A., J. Dent. Res. In press, July 2005.
Commentary: - Is Immunity the Key to Our Periodontal Well-being? Y-T A. Teng, J. Can. Dent. Asso. (Commentary of Clinical Abs.), 70 (7): 476, 2004.

Expression cloning of a periodontitis-associated virulence factor of Actinobacillus actinomycetemcomitans, CagE homologue that encodes a putative type IV secretion protein and induces apoptosis of human cells. Y-T A. Teng & W. Hu. Biochem. Biophys. Res Communs. 303: 1086-1094, 2003.

Differential detection of the 16s-rDNA from periodontal pathogens by multiplex PCR. Doughlas P. Baley & Andy Y-T. Teng. submitted, 2003.

CagE homologue in Actinobacillus actinomycetemcomitans is cytoplasmically located and a secretary protein that induces apoptosis of human epithelial cells: An ultra-structural study. Andy Y-T. Teng, Xiaoxia Zhang, submitted, 2003.

Actinobacillus actinomycetemcomitans-reactive periodontal CD4+T cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. D. Mahamed., A. Marleau., B. Singh., J. Penninger., Y-T A. Teng. submitted, 2003.

The role of acquired immunity in periodontal disease progression. Y-T A. Teng. - Crit. Rev. of Oral Biol. & Med. 14(4): 237-252, 2003.

T-cell-receptor gene usage of the periodontal CD4 T-cells in Actinobacillus actinomycetemcomitans-infected LJP patients and LJP-derived, HuPBL-reconstituted NOD/SCID mice. X. Gao, Y-T A. Teng, J. Periodontol. Res. -Short communication-, 37: 399-404, 2002.

Periodontal health and systemic disorders. Y-T A. Teng, G. Taylor, F. Scannapieco, D. Kinane, M. Kurtis, J. D. Baker, & S. Kogon. J. Can. Dent. Asso. 68 (3): 188-192, 2002.

Mixed human periodontal Th1/Th2 cytokines in Actinobacillus actinomycetemcomitans-specific osteoprotegerin-ligand-mediated alveolar bone destruction in vivo. Y-T A. Teng, Infection & Immunity, Notes; 70 (9):5269-5273, 2002.

Efficient generation of respiratory syncytial virus (RSV)-neutralizing human MoAbs via human peripheral blood lymphocyte (hu-PBL)-SCID mice and scFv phage display libraries. H. Nguyen, J. Hay, T. Mazzulli, S. Gallinger, J. Sandhu, Y-T A. Teng and N. Hozumi. Clin & Exp Immunol, 122:85-93, 2000.

Functional human T-cell immunity and osteoprotegerin-ligand (OPG-L) control alveolar bone destruction in periodontal infection. Y-T A. Teng, H. Nguyen, X. Gao, R. P. Ellen, Bhagirath Singh, Josef Penninger. J. Clin. Invest. [Rapid publication], 106: R59-R67, Sept. 2000.

Periodontal immune responses of human lymphocytes in Actibobacillus actinomycetemcomitans-inoculated NOD/SCID Mice engrafted with peripheral blood leukocytes of periodontitis patients. Yen-Tung Teng, H. Nguyen, A. Hassanloo, R. P. Ellen, N. Hozumi,. J. Periodontal Res. 34:54-61, 1999.

Recent Presentations

Seminar presented for the Association of Dental Research, Taiwan, R.O.C., Annual Meeting: Taipei, Sept 11th, 2005. Special keynote speech: “Emerging new paradigm of alveolar bone loss during the periodontal disease progression: From the molecular understanding to the future clinical treatment”; Hosts: Dr. Leedhe Lin & Lin L. Min, Taipei Dental Association.

Seminar: “Microbes, innate and adaptive immunity, and their playground”. Dept. of Biology, McMaster University, Nov 10, 2005; Host: Dr. Christopher Baron, McMaster University.

Symposium scheduled for the IADR-AADR 2006 annual meeting, Brisbane, Australia; Periodontal symposium - “Oral Mucosal Immune Responses in Health and Disease”, Speakers: Drs. Derek Hart (Australia), Christopher W Cutler (USA), Martin Taubman (USA), Greg G. Seymour (Australia) and Andy Y-T. Teng (USA).