NanotoxicologyNano-sized TiO2 and ZnO particles (20-50 nm) are regular components of sunscreens and numerous cosmetic products because of their UVA and UVB reflecting properties. There is increasing concern that engineered nanoparticles (<100 nm diameter) may penetrate the skin and translocate to secondary sites including lymph nodes, peripheral and central nervous systems. Nanoparticles can induce oxidative stress and cytotoxicity. Hence a need exist to quantify nanoparticle stratum corneum penetration and their translocation fate. Though the Univeristy of Rochester Environmental Health and Science Center (EHSC) and in collaboration with Gunter Oberdorster PhD and Alice Pentland MD we are developing an in vivo mouse model to investigate the effect of nanoparticle size, surface charge and vehicle formulation on skin penetration in normal and erythematous skin produced by UV exposure.
|Qdot lotion applied to mouse back. Collar is used to prevent grooming.||Tissue histology showing QDot below stratum corneum barrier|