Articular Cartilage Development, Maintenance, and Osteoarthritis

Project Overview

Osteoarthritis (OA) is the most common and one of the most costly musculoskeletal disorders in the world. OA is characterized by the loss of articular cartilage within diarthrodial joints leading to impaired skeletal mobility and severe pain. The onset and progression of OA is caused by genetic, mechanical (injury), and aging factors. Our lab is primarily interested in articular cartilage development, the genetic basis of OA, and the development of therapeutics to treat and/or slow the progression of OA. We are currently investigating several molecules that control joint formation and maintenance using tissue specific mouse genetic models and articular chondrocyte cultures. We are also involved in collaborations to create molecular therapeutics for treatment of OA using tissue engineered constructs to deliver drugs and/or MSCs locally to the articular cartilage.

Contact

Matthew J. Hilton, Ph.D.
University of Rochester
601 Elmwood Ave., Box 665
Rochester, NY 14642
Office: SMD 1-8535
(585) 275-1335
matthew_hilton@urmc.
rochester.edu