Growth Plate Cartilage Development and Maturation

Project Overview


Signaling molecules of the Ihh/Pthrp, BMP, FGF, and Wnt pathways are required at multiple stages of normal growth plate cartilage development and maturation. Deregulation of these signaling pathways during development causes a variety of skeletal dysplasias and age related cartilage pathologies due to defects in chondrocyte proliferation and maturation. Recently, we identified the Notch pathway as important regulator of these processes. We are currently employing mouse genetic and primary cell culture techniques to understand the cell and molecular mechanisms by which Notch regulates cartilage formation and maturation. Additionally, we are identifying specific Notch targets and novel regulators of chondrogenesis and cartilage development.

Contact

Matthew J. Hilton, Ph.D.
University of Rochester
601 Elmwood Ave., Box 665
Rochester, NY 14642
Office: SMD 1-8535
(585) 275-1335
matthew_hilton@urmc.
rochester.edu