Mitochondrial Biology (MB)
- Mitochondria in Disease
- Mitochondria in Muscle Function
- Mitochondria in Neuronal Function
- Redox regulation in Biology
Mitochondria regulate signaling, metabolism, and energy production needed for cellular function. Recent scientific studies show that mitochondrial dysfunction is more commonplace than previously thought and that substantial mitochondrial involvement is present in many acute and chronic diseases. Mitochondrial dysfunction is now implicated in a range of human diseases, including aging, diabetes, atherosclerosis, heart failure, myocardial infarction, stroke and other ischemic-reperfusion injuries, neurodegenerative diseases including Alzhiemer’s and Parkinson’s diseases; cancer, HIV; sepsis and trauma with multiorgan dysfunction or failure. Given the critical role of mitochondrial function discovering the fundamental mechanisms of mitochondrial function and dysfunction is a unifying theme for the development of therapeutic strategies for human health.
 |
 |
 |
Paul S. Brookes, Ph.D.Mitochondrial interactions with free radicals (nitric oxide, superoxide) in the context of myocardial ischemia reperfusion. |
 |
Robert T. Dirksen, Ph.D.Calcium channel structure and function. |
 |
Robert S. Freeman, Ph.D.Molecular mechanisms of neuronal death. |
 |
Gail V.W. Johnson, Ph.D.Mitochondrial dysfunction and the molecular mechanisms of neurodegeneration; the regulation and function of transglutaminase 2; tau pathology in Alzheimer's disease; the role of mitochondria in the pathogenesis of Huntington's disease. |
 |
George A. Porter, Jr., M.D., Ph.D.Regulation of cardiac development by intracellular calcium signaling and mitochondrial biogenesis. |
 |
Yisang Yoon, Ph.D.Cell biology of mitochondria: Regulation of mitochondrial dynamics. |
