Does this test have other names?
Serum osmolality, osmolality serum
What is this test?
This test measures the concentration of dissolved particles, or osmolality, in your blood.
This test can help diagnose a fluid or electrolyte imbalance. Electrolytes are mineral salts that help move nutrients into your cells and waste products out of your cells.
Electrolytes also control your acidity and pH levels. The more dilute your blood and urine are, the lower the concentration of particles. The less water in your blood, the greater the concentration of particles. Osmolality increases when you are dehydrated and decreases when you have a fluid buildup.
Your body has a unique mechanism that controls osmolality. When osmolality increases, it triggers your body to make antidiuretic hormone (ADH). Your kidneys then conserve more water inside your body and your urine becomes more concentrated. When osmolality decreases, your body doesn't produce as much ADH, and your blood and urine become more dilute.
Why do I need this test?
You may have this test if you have seizures or problems with ADH. You may also have this test if you are dehydrated or if your doctor thinks you might have diabetes insipidus. Diabetes insipidus happens when your body makes less ADH. It's also called vasopressin. This condition can also happen if your kidneys are not responding to ADH, even though you are making enough of it. Symptoms of diabetes insipidus include:
Frequent need to urinate
Very dilute urine
Dizziness when standing
You might also have this test if you have symptoms of hyponatremia. Hyponatremia is a condition in which your body retains fluid because it doesn't have enough sodium, an electrolyte. Symptoms of hyponatremia include:
Nausea and vomiting
Spasms or cramps
Seizures or passing out
You may also have this test if you are in a coma. When osmolality increases, it can cause fatal grand mal seizures.
What other tests might I have along with this test?
Your doctor may also order a urine osmolality test. The results of both urine osmolality and blood osmolality tests help figure out the cause of osmolality problems.
Your doctor may also order:
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your health care provider.
Results are given in milliosmoles per kilogram (mOsm/kg). Normal results are:
If your levels are higher or lower, it may mean you have one of these conditions:
A level that's beyond normal range may also be caused by blood loss, as from trauma, or prolonged vomiting or diarrhea.
How is this test done?
The test requires a blood sample, which is drawn through a needle from a vein in your arm.
Does this test pose any risks?
Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.
What might affect my test results?
Eating a poor diet or drinking too much water can affect your results. Intense exercise and being under stress can also affect your results. Certain medications and the illicit drug ecstasy can also affect your results.
How do I get ready for this test?
You don't need to prepare for this test. But be sure your doctor knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use. Also tell your doctor if you have been drinking a lot of water.
- Marcellin, Lindsey, MD, MPH
- Ziegler, Olivia Walton, MS, PA-C