Parathyroid Tumor
What is a parathyroid tumor?
Cancer starts when cells change (mutate) and grow out of control. The changed (abnormal)
cells often grow to form a lump or mass called a tumor. Cancer cells can also grow
into (invade) nearby areas. They can spread to other parts of the body, too. This
is called metastasis.
A parathyroid tumor is a growth inside a parathyroid gland. Most parathyroid tumors
are not cancer (they're benign). Parathyroid cancers are very rare. You have 4 parathyroid
glands. They are small, pea-sized glands in your neck or upper chest near the thyroid
gland. They’re part of the endocrine system. This system controls hormones in your
body.
The parathyroid glands make parathyroid hormone. This hormone controls the levels
of calcium and phosphorus in your blood. Parathyroid tumors that are not cancer may
cause high levels of this hormone. This increases the amount of calcium in your blood. Parathyroid
cancer causes very high levels of the hormone. This can lead to dangerously high levels
of calcium in your blood. This is called hypercalcemia.
Who is at risk for a parathyroid tumor?
A risk factor is anything that may increase your chance of having a disease. The exact
cause of someone’s cancer may not be known. But risk factors can make it more likely
for a person to have cancer. Sometimes you can control risk factors, like using sunscreen
to lower your risk for skin cancer. But risk factors for parathyroid tumors aren't
in your control.
Anyone can get a parathyroid tumor. But you are more at risk for one if you:
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Had radiation therapy to your neck
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Were exposed to high doses of radiation from nuclear power plants
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Have a family history of parathyroid tumors
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Have certain inherited conditions, such as familial isolated hyperparathyroidism or
multiple endocrine neoplasia, types 1 or 2
Talk with your healthcare provider about your risk factors for parathyroid tumors
and what you can do about them.
Can a parathyroid tumor be prevented?
Experts aren’t exactly sure what causes parathyroid tumors. At this time, there’s
no known way to prevent them.
Are there screening tests for a parathyroid tumor?
There are no routine screening tests for parathyroid tumors in people at average risk.
Screening is done to check for disease in people who don’t have symptoms.
What are the symptoms of a parathyroid tumor?
They may include:
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Aches and pains, especially in your bones
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Kidney problems, including kidney stones and pain in your upper back or side
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Depression
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High blood pressure
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Loss of appetite
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Intense thirst
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Nausea
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Vomiting
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Feeling very tired, even after rest
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Constipation
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Frequent urination
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Confusion and memory problems
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Weakness
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A lump in the neck
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Trouble sleeping
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Voice changes, like hoarseness
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Bone thinning (osteoporosis)
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Problems swallowing
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Irregular heart rhythm
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Unintentional weight loss
Most symptoms of parathyroid tumor are caused by hypercalcemia (high levels of calcium
in the blood). But many of these may be caused by other health problems. It’s important
to see a healthcare provider if you have these symptoms. Only a healthcare provider
can tell if you have a tumor or cancer.
How is a parathyroid tumor diagnosed?
Parathyroid problems are often found when you see a healthcare provider because of
symptoms that aren’t getting better. Your provider will ask you about your health
history, symptoms, risk factors, and family history of disease. You will also have
a physical exam. You may also need one or more of these tests:
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Blood or urine tests. These can detect high levels of calcium or parathyroid hormone in your body. They
can also help give an idea of your overall health and organ function.
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Imaging tests. These include X-rays, ultrasound, CT scans, and MRIs. They can help look for tumors
and find out how big they are.
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Sestamibi/SPECT scan. This test can show if you have an overactive parathyroid gland. A radioactive substance
is put into your blood through a vein in your arm. The substance travels to the overactive
gland and collects there. An X-ray can then show the buildup in the gland. This scan
can also help find tumors in other parts of your body.
After a diagnosis of parathyroid tumor, you’ll need more tests. For instance, a biopsy
may be done. This is when tiny pieces of tissue (called samples) are taken from the
tumor. These samples are sent to a lab and tested to see if there are cancer cells
in them.
These tests help your healthcare providers learn whether the tumor is cancer. Sometimes
you won’t know if the tumor is cancer until after surgery. Then tests can be used
to find the stage of the cancer. The stage is how much cancer there is and how far
it has spread (metastasized) in your body. It’s one of the most important things to
know when deciding how to treat cancer.
Once your cancer is staged, your healthcare provider will talk with you about what
the stage means for your treatment. Be sure to ask your healthcare provider to explain
the details of your cancer to you in a way you can understand.
How is a parathyroid tumor treated?
Your treatment choices depend on the type of parathyroid tumor you have, test results,
the stage of the cancer, whether your blood calcium levels can be controlled, and
whether the tumor can be removed with surgery. Your overall health, how your body
will look and work after treatment, and your personal choices will also be taken into
account.
Treatment is used to destroy the tumor and control your blood calcium levels. Talk
with your healthcare team about your treatment choices, the goals of treatment, and
what the risks and side effects may be.
Types of treatment for cancer are either local or systemic. Local treatments remove,
destroy, or control cancer cells in one area. Surgery and radiation are local treatments.
Systemic treatment is used to destroy or control cancer cells that may have traveled
around your body. When taken by pill or injection, chemotherapy and targeted therapy
are systemic treatments. You may have just one treatment or a combination of treatments.
Surgery is the most common treatment for parathyroid tumors. The goal is to remove as much
of the tumor as possible. Before surgery, you may be given medicine to control the
amount of calcium in your blood until surgery is done. After surgery, you'll need
regular blood tests to be sure your calcium levels don't get too low.
In some cases, a benign (not cancer) parathyroid tumor doesn’t need to be taken out.
It may need to be removed only if your calcium level has reached a certain level or
if you have severe symptoms. Some people with hyperparathyroidism (high parathyroid
hormone levels) need surgery if they develop thinning of their bones (osteoporosis),
kidney stones, or their kidneys don’t work correctly.
If the tumor is cancer, you'll need surgery to remove the gland and tissues around
it. After surgery, you may also need:
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Radiation therapy. This kills the cancer cells and helps keep them from growing and spreading. It might
be used to help decrease the chance that the cancer will come back. Sometimes it's
used if surgery can't be done.
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Chemotherapy. These medicines kill cancer cells. They're not a common part of parathyroid cancer
treatment at this time.
Talk with your healthcare providers about your treatment options. Make a list of questions.
Think about the benefits and possible side effects of each option. Talk about your
concerns with your healthcare provider before making a decision.
What are treatment side effects?
Cancer treatments, like chemotherapy and radiation, can damage normal cells. This
can cause side effects like hair loss, mouth sores, and vomiting.
Talk with your healthcare provider about side effects linked with your treatment.
There are often ways to manage them. Be sure to tell your healthcare team what side
effects you have. There may be things you can do and medicines you can take to help
prevent or control many treatment side effects.
Coping with a parathyroid tumor
Many people feel worried, depressed, and stressed when dealing with cancer. Getting
treatment for cancer can be hard on your mind and body. Keep talking with your healthcare
team about any problems or concerns you have. Work together to ease the effect of
cancer and its symptoms on your daily life.
Here are some tips:
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Talk with your family or friends.
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Ask your healthcare team or social worker for help.
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Speak with a counselor.
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Talk with a spiritual advisor, such as a minister or rabbi.
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Ask your healthcare team about medicines for depression or anxiety.
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Keep socially active.
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Join a cancer support group.
Cancer treatment is also hard on the body. To help yourself stay healthier, try to:
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Eat a healthy diet, with a focus on high-protein foods.
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Drink plenty of water, fruit juices, and other liquids.
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Keep physically active.
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Rest as much as needed.
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Talk with your healthcare team about ways to manage treatment side effects.
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Take your medicines as directed by your team.
When should I call my healthcare provider?
Your healthcare provider will talk with you about when to call. You may be told to
call if you have any of the below:
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New symptoms or symptoms that get worse
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Signs of an infection, such as a fever
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Side effects of treatment that affect your daily function or don’t get better with
treatment
Ask your healthcare provider what signs to watch for and when to call. Know how to
get help after office hours and on weekends and holidays.
Key points about a parathyroid tumor
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A parathyroid tumor is a growth inside one of the four parathyroid glands in the body.
These glands are found in the neck or upper chest near the thyroid gland.
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Parathyroid tumors are often benign (not cancer). But some can be cancer.
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These tumors can cause hypercalcemia, a serious condition in which the body has too
much calcium in it.
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The exact cause of these tumors is not known. But a family history may raise the risk
for them.
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The main treatment is surgery to remove the tumor, even if it’s not cancer.
Next steps
Tips to help you get the most from a visit to your healthcare provider:
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Know the reason for your visit and what you want to happen.
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Before your visit, write down questions you want answered.
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Bring someone with you to help you ask questions and remember what your provider tells
you.
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At the visit, write down the name of a new diagnosis and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
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Know why a new medicine or treatment is prescribed and how it will help you. Also
know what the side effects are.
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Ask if your condition can be treated in other ways.
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Know why a test or procedure is recommended and what the results could mean.
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Know what to expect if you don't take the medicine or don't have the test or procedure.
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If you have a follow-up appointment, write down the date, time, and purpose for that
visit.
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Know how you can contact your provider if you have questions or concerning signs and
symptoms.