Integrative Health Sciences Facility Core The Integrative Health Sciences Facility Core (IHSFC) was established in 2007 to provide tools and approaches that facilitate translational studies, as well as to enhance partnerships among researchers, Medical Center units such as the URMC's Clinical and Translational Science Institute, and community-based organizations that impact the conduct of clinical and public health research. The IHSFC is designed to assist basic science investigators in moving their research in the direction of clinical/translational studies through the use of appropriate animal models of disease, human tissues, or direct clinical and public health applications. In addition, the IHSFC also provides clinical scientists with a means to refine questions and approaches to mechanisms, develop more relevant animal models, and increase treatment specificity and efficacy. Steering Committee Members Steve N. Georas, M.D. (Co-Director) Edwin VanWijngaarden, Ph.D. (Co-Director) Deborah A. Cory-Slechta, Ph.D. (Co-Director) Katrina Korfmacher, Ph.D. Gloria Pryhuber, M.D. David Rich, Sc.D., M.P.H. Translational Services in Environmental Health Unit Faculty considering translational research can contact the IHSFC Steering Committee for assistance in identifying potential collaborators, acquiring funding, conducting Human Subjects research, designing and executing epidemiological and population based studies, accessing on-site repositories of samples and tissues from human subjects and obtaining histology services. See the Translational Services in Environmental Health page for more information. Behavioral Sciences Facility The Behavioral Sciences Facility provides state–of–the–art equipment and expertise necessary for the design and interpretation of human and animal behaviors in order to assess sensory, motor, motivational and cognitive functioning. The facility assists investigators with behavioral assessments, utilizing established procedures and tests, or when necessary, developing new behavioral paradigms. To schedule services, visit the Behavioral Sciences Facility website. Animal/Human Inhalation Facility The Inhalation Facility contains both human and animal exposure facilities, providing a unique opportunity to study the effects of aerosol exposure on humans and animal models. See the Animal/Human Inhalation Facility page for contact information. Projects Facilitated by the IHSFC The IHSFC steering committee assisted Dr. Marc Williams in writing a successful application to the Research Subjects Review Board for a project investigating the effects of allergens and particulate matter on peripheral blood dendritic cells. As of Dec 2008, the study has recruited 12 human subjects and generated preliminary data for a successful research grant from the Health Effects Institute. The IHSFC steering committee assisted Dr. Irfan Rahman in writing a successful application to the Research Subjects Review Board for a pilot study investigating biomarkers of lung inflammation in smoking and non-smoking subjects with chronic obstructive pulmonary disease. Translational Services staff worked with Dr. Rahman to develop strategies for subject recruitment and retention. As of December 2008, the study enrolled 24 smoking and non-smoking subjects.