Lin Gan, PhD
- Dean's Professorship - Department of Dean's Office, SMD (SMD)
- Professor - Department of Ophthalmology (SMD) - Primary Appointment
- Professor - Department of Center for Visual Science (RC)
- Professor - Department of Neurobiology and Anatomy (SMD)
- PhD | Biochemistry, All Other | U Tex-Houstn Grad Sch Biomd Sc (1992)
The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level.
My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement. I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to regulate the differentiation of neuronal progenitor cells into specific types of neurons and to regulate the maturation and survival of post-differentiation neurons.
Showing 5 of 72 journal articles.
Luo XJ; Deng M; Xie X; Huang L; Wang H; Jiang L; Liang G; Hu F; Tieu R; Chen R; Gan L. "GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea." Human molecular genetics. 2013; 22: 3609-3623. (Cover Photograph)..
Luo XJ; Huang L; Li M; Gan L. "Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia." Schizophrenia research. 2013; 143(2-3):390-2. Epub 2012 Dec 29.
Li M; Luo XJ; Rietschel M; Lewis CM; Mattheisen M; Müller-Myhsok B; Jamain S; Leboyer M; Landén M; Thompson PM; Cichon S; Nöthen MM; Schulze TG; Sullivan PF; Bergen SE; Donohoe G; Morris DW; Hargreaves A; Gill M; Corvin A; Hultman C; Toga AW; Shi L; Lin Q; Shi H; Gan L; Meyer-Lindenberg A; Czamara D; Henry C; Etain B; Bis JC; Ikram MA; Fornage M; Debette S; Launer LJ; Seshadri S; Erk S; Walter H; Heinz A; Bellivier F; Stein JL; Medland SE; Arias Vasquez A; Hibar DP; Franke B; Martin NG; Wright MJ; ; Strohmaier J; Breuer R; Meier S; Mühleisen TW; Degenhardt FA; Hoffmann P; Herms S; Schwarz M; Vedder H; Kammerer-Ciernioch J; Reif A; Sasse J; Bauer M; Zwick S; Hautzinger M; Wright A; Mitchell PB; Fullerton JM; Schofield PR; Montgomery GW; Martin NG; Czerski PM; Hauser J; Schumacher J; Maier W; Propping P; ; Backlund L; Frisén L; Lavebratt C; Schalling M; Osby U; ; ; ; Su B. "Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility." Molecular psychiatry. 2013; Epub 2013 Apr 09.
Luo X; Huang L; Jia P; Li M; Su B; Zhao Z; Gan L. "Protein-Protein Interaction and Pathway Analyses of Top Schizophrenia Genes Reveal Schizophrenia Susceptibility Genes Converge on Common Molecular Networks and Enrichment of Nucleosome (Chromatin) Assembly Genes in Schizophrenia Susceptibility Loci." Schizophrenia bulletin. 2013; Epub 2013 May 12.
Jiang Y; Ding Q; Xie X; Libby R; Lefebvre V; Gan L. "Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells." The Journal of biological chemistry. 2013; 288(25):18429-38. Epub 2013 May 06.
Lin Gan, PhD
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 659
Rochester, NY 14642
Office: (585) 273-1510
Lab: (585) 273-1513
Fax: (585) 276-2432