Optical Micro-Machining using Femtosecond Lasers

Project Overview

Femto Micro-machiningIRIS stands for Intratissue Refractive Index Shaping. It is a process invented at the University of Rochester by a team of scientists under the leadership of Dr's. Krystel Huxlin and Wayne Knox who demonstrated that it was possible to use a low-energy, high-repetition rate femtosecond laser to alter the refractive index of transparent, living tissues (such as the cornea and lens) without causing massive amounts of tissue damage or inducing a wound healing and scarring response.

Our long-term goal with this research is to develop the use of femtosecond micromachining as a non-damaging method of customizing the refractive correction in a human eye, be it in the cornea, lens or implanted IOLs. Current experiments are first testing and developing this technology in animal models, with specific projects including:

  1. assessing the durability of inscribed femto-IRIS patterns in a living cornea over time,
  2. assessing the biological reaction and especially, the presence or absence of a corneal wound healing reaction to an inscribed femto-IRIS pattern in a living cornea over time,
  3. assessing the wavefront aberration changes induced by a spherical or cylindrical IRIS pattern over time.

Optical Micro-machiining using Femtosecond Lasers


Krystel Huxlin, Ph.D.
University of Rochester
School of Medicine and Dentistry 601 Elmwood Ave., Box 659
Rochester, NY 14642


Holly Hindman, M.D.

Scott MacRae, M.D.

Past Collaborator

Jens Bühren, M.D.